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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Nov 11,2021
Chiral Drug Synthesis
Chiral drugs refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the "Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, theRead more
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Chiral Drug Synthesis
Nov 08,2021
Two Leading CRO Organizaitons in America in 2020
Business Structure Comparison LabCorp and IQVIA are the world's leading CRO organizaitons, and these two organizaitons have been catching up with you. LabCorp is mainly composed of two major businesses, LabCorp Diagnostics (LCD) and Covance Drug Development (CDD), and CDD is composed of Covance Inc., which was acquired in 2015, and is also the leaderRead more
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Two Leading CRO Organizaitons in America in 2020
Nov 08,2021
Top 10 Global Clinical Research Organizations in 2021
In 2020, a global outbreak of the new crown epidemic disrupted the business activities of almost all companies, and the drug R&D and production of pharmaceutical companies was no exception. As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market order is chaotic.
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Top 10 Global Clinical Research Organizations in 2021
Nov 05,2021
Drug Local Toxicity Test
Local toxicity refers to the damaging effects of certain drugs directly caused by the contact parts of the body. It initially manifests as cell death at the site of direct contact. Mainly include irritation test, allergy test, hemolysis test. Irritation test: Irritation refers to the reversible inflammatory reaction to the administration site after the administrationRead more
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Drug Local Toxicity Test
Nov 04,2021
Influence of Hemolysis on Test Results
Specimen hemolysis is one of the most common interference and influence factors in clinical biochemical examination. Hemolysis leads to inaccurate test results, which cannot objectively reflect the patient's physical condition at that time. The influence of specimen hemolysis on clinical test results is as follows: 1. Influence on RBC Count and RBC Specific Volume  In hemolysisRead more
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Nov 03,2021
Abnormal Result Caused by Hemolysis of Blood Samples
⑴ Influence on biochemical results: Specimen hemolysis is the most common interference and influencing factor in clinical biochemical tests. Hemolysis has an impact on a considerable part of biochemical testing items. Among them, total bilirubin (TBIL), aspartate aminotransferase (AST), total protein (TP), and albumin (ALB) are significantly increased after hemolysis; significant after hemolysis The itemsRead more
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Abnormal Result Caused by Hemolysis of Blood Samples
Nov 03,2021
Influence of Hemolysis on the Analysis of Biological Samples
Hemolysis refers to the rupture of red blood cells and the escape of hemoglobin into plasma or serum, which can occur in vivo and in vitro. The factors affecting hemolysis are also very complicated. After hemolysis of plasma and serum, many physiological components such as hemoglobin, bilirubin, phospholipids, etc. increase significantly. These components may affectRead more
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Nov 03,2021
Hemolysis Test
Hemolysis test: refers to the hemolysis and red blood cell aggregation caused by pharmaceutical preparations. Hemolytic reactions include immune hemolysis and non-immune hemolysis. 1. Prepare 2% Red Blood Cells Baoding rabbits, draw blood from the heart 5 m, add 0.2 ml of anticoagulant EDTA, wash with PBS, centrifuge to remove the white blood cells onRead more
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Nov 03,2021
Common Biological Experiment Testing Items
Biological Test Items Under GLP Regulations: Single and multiple dose toxicity test (rodent)Single and multiple dose toxicity test (non-rodent) Reproductive toxicity test (I, II)Genetic toxicity test (Ames, micronucleus, chromosome aberration) Local toxicity test (allergic, irritation, hemolysis) Immunogenicity/Immune toxicology test Safety pharmacology test Toxicokinetic test Carry out systematic pharmacokinetic studies according to the requirements of theRead more
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Oct 29,2021
Factors Affecting Metabolism
Metabolism is the process of changing the chemical structure of drugs in the human body. The main organ that can metabolize drugs in the human body is the liver, followed by the small intestine, kidney, lung, and brain tissue. For more details, please read Factors Affecting Pharmacokinetics of Drugs. Factors Affecting Drug Metabolism: Genetic factors:Read more
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Factors Affecting Metabolism