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Research Progress on Pharmacokinetics of Traditional Chinese Medicine

2016-02-15
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At present, the research on the pharmacokinetics of traditional Chinese medicine is still in the exploratory stage. Since the 1980s, the pharmacokinetics of traditional Chinese medicine has been greatly developed. This article reviews the pharmacokinetic research progress of some clinically commonly used active ingredients of traditional Chinese medicine. Starting from the characteristics and research status of traditional Chinese medicine, it points out the shortcomings of various research methods and emphasizes that the pharmacology and pharmacokinetics of traditional Chinese medicine should be further strengthened. Clarifying the process and mechanism of Chinese medicine has an important impact on the modernization goal of Chinese medicine.

Pharmacokinetics of traditional Chinese medicine, modernization of traditional Chinese medicine, meanwhile pointed out the problems that should be solved in the research of pharmacokinetics of traditional Chinese medicine in the future.

Pharmacokinetics is the application of kinetic principles and mathematical processing methods, which quantitatively describe the dynamic changes of the absorption, distribution, metabolism, and excretion processes of drugs after entering the body through various routes of administration, that is, to study the drug in the body after administration The relationship between the location, number, curative effect and time. Pharmacokinetics is also called “pharmacokinetics”, “pharmacokinetics”, etc. The meaning of “metabolism” includes the absorption, distribution, metabolism and excretion of drugs in the body. Pharmacokinetics is an emerging border subject between pharmacy and mathematics. It has become biopharmaceutical, clinical pharmacy, pharmacology, clinical pharmacology, molecular pharmacology, biochemistry, pharmacy, toxicology, etc. The foundation of these disciplines promotes the vigorous development of these disciplines. The research results of pharmacokinetics in recent decades have played an important role in guiding the research of new drugs, formulating the best clinical dosing plan, evaluating the quality of preparations, and improving the formulation of drugs. The pharmacokinetics of traditional Chinese medicine is the research object of traditional Chinese medicine and its compound prescriptions. It refers to the quantitative description of the effective ingredients, effective parts, single Chinese medicine and traditional Chinese medicine compound prescriptions using the principles of kinetics and mathematical processing methods under the guidance of the theory of Chinese medicine. The dynamic changes of absorption, distribution, metabolism and excretion after entering the body through various administration routes. The pharmacokinetics of traditional Chinese medicine is of great significance to the modernization of traditional Chinese medicine and the development of traditional Chinese medicine to the world. The research methods can be roughly divided into two categories: blood concentration method and biological effect method. At the same time, as the research on the pharmacokinetics of traditional Chinese medicine has been paid more and more attention, advanced detection technologies have continued to increase, and some new technologies and new methods have emerged, such as critical fluid extraction, in vivo microdialysis, nuclear magnetic resonance, bioelectrical impedance, and cell culture. Study in vitro absorption model, syndrome and treatment pharmacokinetics, serum pharmacology of traditional Chinese medicine, gastrointestinal pharmacokinetics of traditional Chinese medicine, etc.

Application of PB-PK model

The blood concentration method and the biological effect method currently occupy the leading position in the research of compound pharmacokinetics. The structure of the PB-PK model roughly corresponds to the anatomical structure of the organism. The parameters are derived from physiological anatomical data and the physical and chemical properties of the medicine. The PB-PK model analyzes the time data based on the physiological anatomical data and the physical and chemical properties of the medicine, and has a strong inter-species The ability of extrapolation (InterspeciesExtrapolation) , the obtained parameters have more practical physiological significance, and are more superior and practical than the compartment model, and can provide parameters that other models cannot provide (such as the metabolic rate of drugs in human organs). Constants, diffusion coefficients into organs, etc.), so it is necessary to strengthen the study of the PB-PK model of traditional Chinese medicine compounds. The parameters of the PB-PK model provide more practical parameters as a reference for the compatibility of the compound.

Summary

At present, the pharmacokinetic research of traditional Chinese medicine is still in the exploratory stage. Although great progress has been made in the study of pharmacokinetics of traditional Chinese medicine, there are still problems in many aspects that need to be solved by us. First of all, it is difficult to grasp the overall view of traditional Chinese medicine. At present, most researches on traditional Chinese medicine compounds take one or several components as the representative of the metabolic process of this component to represent the entire metabolic process of the compound. Obviously, it is rare in Chinese medicine prescriptions that rely on a single component to act on a single target to exert all the pharmacological functions. Both the compound and the single prescription are a complex system, and multiple components are mutually antagonistic and synergistically produced.

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