Medicilon Logo
search icon search icon language icon contact icon menu icon
Medicilon Logo
search icon close search icon language icon contact icon menu icon
Contact Us
Close Button
Back To Top
Online Message×
Click switch
Close Button
Medicilon's News information
News information

The Development Trend of Modern Analytical Chemistry

Page View:

Factors affecting the stability of traditional Chinese medicine preparations

Chemical degradation reactions of drugs: hydrolysis, oxidation, isomerization, polymerization, decarboxylation, etc. Main degradation pathways: hydrolysis and oxidation.

  1. Types of drugs that are easily hydrolyzed and easily oxidized

(1) Types of easily hydrolyzed drugs

① Ester drugs: Andrographolide;

②Amide drugs: penicillin;

③Glycoside drugs: Cardiac glycosides are easily hydrolyzed. Digitalis tincture is mostly leached with 70% ethanol.

(2) Types of easily oxidized drugs

① Contains phenolic hydroxyl group or potential phenolic hydroxyl group, such as baicalin;

② Grease and volatile oil with unsaturated carbon chain.

Medicilon's analytical chemistry, purification and separation team is able to offer high-quality services. We are well-regarded by our clients for our deep experience and problem-solving skills.

  1. Factors affecting the stability of traditional Chinese medicine preparations

(1) Prescription factors:

①pH: Liquid preparations are usually relatively stable in a specific pH range;

②The influence of solvent, matrix and other auxiliary materials.

(2) Preparation technology

(3) Storage conditions:


②Light: Phenolic drugs-oxidation reaction, ester drugs-reaction, volatile oil-polymerization reaction (appropriate light-shielding container packaging should be selected);

③Oxygen and metal ions;

④Humidity and moisture;

⑤Packaging materials.

  1. The packaging and storage of preparations require shading:

Use opaque containers for packaging, such as colorless, transparent, and translucent containers wrapped in brown containers or black packaging materials.

Avoid light: Avoid direct sunlight.

Airtight: Keep the container tightly closed to prevent dust and foreign objects from entering.

Seal: Seal the container to prevent weathering, moisture absorption, volatilization or foreign matter from entering.

Melt seal: Melt seal the container or seal it tightly with a suitable material. To prevent the intrusion of air and moisture and prevent pollution.

Shady and cool place: the storage temperature should not exceed 20℃.

Cool and dark place: Store under dark conditions and the temperature does not exceed 20°C.

Cold place: The storage temperature is 2℃~10℃.

Room temperature: The storage temperature is 10℃~30℃.

Relevant newsRelevant news