Early Pharmacokinetics

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Service

• Plasma protein binding testsPlasma stability testsLiver microsome stability testsHepatocyte metabolic stability testsS9 stability testsCYP450 enzyme inhibition testsCYP450 enzyme induction testsEnzyme phenotype analysisMetabolite speculationMetabolite confirmationEstimation of metabolic pathwaysConfirmation of metabolic pathwaysTransmembrane transport tests (Caco-2, P-gp, BCRP, etc.)Drug-drug interactionWhole blood/plasma distribution tests

Service Platform

• The micromolecule analysis instrument platform represented by Sciex/Waters/Shimadzu ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) and Thermo Q Exactive HF-X quadrupole/ultra-high-field fourier transform ion trap high-resolution mass spectrometry  The macromolecule analysis instrument platform represented by the MSD high-throughput multi-protein detector, Luminex liquid-phase chip protein analysis system, the Gyrolab nano-upgraded microfluidic immunoassay workstation and the Applied Biosystems real-time fluorescent quantitative PCR system  The sample pretreatment platform represented by the Covaris AFA adaptive focused acoustics high-performance sample processing system, the KingFisher Flex automatic magnetic bead extraction and purification system, the Lysera high-efficiency sample crusher and the TurboVap high-speed sample concentrator  The sample management platform composed of Thermo/Panasonic ultra-low temperature refrigerators, the SensaTronics temperature monitoring system and the Watson LIMS laboratory information management software

Relevant laboratories

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