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Preclinical Research

Histopathological Study

In diagnosis, histopathological diagnosis is considered as the gold standard to determine diseases and their natures. Before the body shows obvious clinical symptoms, the influence of drugs on the body tissues and organs can be found through histopathological examination, so as to provide reference for the prevention and treatment of diseases. In drug filing, all relevant institutions pay great attention to the results of histopathological diagnosis because such results can provide important basis for judging the potential harm degree of the drugs to be filed.

The guidelines issued by various regulatory agencies also require histopathological diagnosis results of short-term toxicity, subchronic toxicity, chronic toxicity and carcinogenicity tests. As a comprehensive CRO enterprise, Medicilon provides considerate services in histopathology.

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Medicilon diamond icon.pngService
  • We provide comprehensive services:
    In the aspect of pathological diagnosis, we can provide pathological diagnosis services for many kinds of animals, including but not limited to rats, mice, guinea pigs, rabbits, dogs, non-human primates and miniature pigs;In terms of toxicity tests, we are proud of our rich experience, especially in short-term toxicity tests, subchronic toxicity tests, chronic toxicity tests and carcinogenicity research;As for diagnosis requirements of special tissues and organs put forward by some clients, we can provide active exploration methods and solutions to fully meet the pathological diagnosis requirements including drug filing. In terms of different staining techniques, in addition to routine paraffin section H&E staining, we are also available for frozen section, special staining, immunohistochemical staining, TCR, etc. to provide diagnostic services, so as to meet the needs of clients for tissue observation of specific tests.
  • H&E
    H&E staining.png
  • Special staining
    Special staining - safranin-fixed green staining.pngSpecial staining - PAS staining.png
  • Immunohistochemical staining
    Immunohistochemical staining 1.pngImmunohistochemical staining 2.png
  • At present, the microscopes used for diagnosis in Medicilon are mostly OLYMPUS optical microscopes, and each microscope is equipped with a corresponding imaging system to meet the shooting requirements of clients for special histopathological changes. The multi-head OLYMPUS optical microscope is available for multiple people to observe slices and diagnose at the same time, and can also provide help for study and consultation. The Leica microscope (with imaging system) for immunofluorescence observation can meet the requirements of clients for detecting special components by immunofluorescence method. In addition, our new Leica Aperio GT450 scanner can scan slices in batches, convenient for sharing and checking digitized slices.
    OLYMPUS optical microscope.png

    The microscopes used for diagnosis in Medicilon are mostly OLYMPUS optical microscopes, and each microscope is equipped with a corresponding imaging system to meet the shooting requirements of clients for special histopathological changes.

    Multi-head OLYMPUS optical microscope.png

    The multi-head OLYMPUS optical microscope is available for multiple people to observe slices and diagnose at the same time, and can also provide help for study and consultation.

    The Leica microscope (with imaging system) for immunofluorescence observation can meet the requirements of clients for detecting special components by immunofluorescence method.

    Leica fluorescence microscope.png

    In addition, our new Leica Aperio GT450 scanner can scan slices in batches, convenient for sharing and checking digitized slices.

    Leica-Aperio-GT450 scanner.png         Leica--eSlide analysis management software.png

  • At present, Medicilon has 6 pathologists with rich diagnosis experience, of whom 2 are especially good at pathological diagnosis of carcinogenicity-related diseases. In 2020, Medicilon was granted the Evaluation Certificate for Inter-laboratory Comparison for Toxicological Pathology Laboratories by the Committee of Toxicological Pathology, CST. In order to meet the increasing demand of peer review at home and abroad, we have long-term cooperation with experts like Japanese and American toxicological pathologists, so as to meet the needs of clients for domestic and international filing.
    Evaluation Certificate for Inter-laboratory Comparison for Toxicological Pathology Laboratories.png
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