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Drug Discovery

Biology Research

Our Biology Department boasts a variety of technical solutions, professional scientific research teams, various advanced biological instruments and biological laboratories. Medicilon has rich experience in biological fields such as molecular biology, cell biology, in vitro biology, structural biology, among others. With our technical platforms such as enzyme level and cell level measurement platforms, we help our clients select compounds and research their properties, action mechanism and bio-marker analysis, thus ensuring the effective implementation of our clients' projects and helping promote the process of drug R&D.

Computational Biology & Molecular Modeling

In addition to the traditional biological research methods, Medicilon has developed faster and more effective tools. Using computers and big data to assist in early drug R&D, we reduce the workload of drug researchers, reduce the cost of drug development and shorten cycles of drug development.

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Enzymology & Molecular Interactions

Our Biology Department has rich experience in the field of in vitro biology, and is available for a complete set of biological services featuring enzyme level measurement, cell level measurement, cell biology, biochemistry, isotope measurement in vitro, establishment of stable cell lines, gene knockout, RNAi and MicroRNA technology, etc.

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CHO Cell Protein Expression System
Featuring protein folding and post-translational modification, mammalian protein expression systems can make proteins closer to the natural ones, thus obtaining the same biological activity as natural proteins. Therefore, the mammalian cell expression system has been widely applied in the R&D and production of recombinant protein drugs, especially therapeutic recombinant monoclonal antibody drugs.
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Insect Cell Protein Expression System
The baculovirus expression vector system (BEVS) has been widely used in the preparation of various recombinant proteins since 1983, especially in the expression of recombinant kinases and protein complexes. Our researchers have developed mature baculovirus-insect cell expression service that includes the preparation of recombinant baculoviruses, and the expression and purification of recombinant proteins and its complexes.
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Yeast Protein Expression System
Widely used in the production and preparation of recombinant proteins, especially eukaryotic proteins, the yeast expression system has the advantage of both prokaryotic and advanced eukaryotic systems. It is characterized by common culture conditions, fast growth, low cost, capability of post-translational processing of protein, and easy access to soluble active recombinant protein. Pichia pastoris has become the preferred yeast of choice ffor expressing recombinant proteins due to its rapid growth, abundant commercial expression vectors, and high-efficiency secretory expression.
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