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Biology Research

Biology Research

Our Biology Department boasts a variety of technical solutions, professional scientific research teams, various advanced instruments and biological laboratories. Medicilon has broad experience in fields such as molecular biology, cell biology, in vitro biology, and structural biology.

With our technical platforms such as enzyme level and cell level measurement platforms, we can enable our clients to select compounds and research their properties, action mechanism and provide bio-marker analysis, thus ensuring the effective implementation of our clients' projects and helping promote the process of drug R&D.

Biology Service Model & Advantages
  • biology.wenp
    biology.wenp
    Biology Division has been dedicated to drug discovery services for over 19 yearsServing over 300 clients annuallyOver 1000 screening methods established, generating over 2 million data points per yearConducted conformational studies for more than 200 targetsCell library with over 400 tumor cell lines for drug sensitivity testingRich knowledge base with more than 50 new experimental methods and 5 new platforms per yearClinical biomarker detection system has been gradually improved, with the ability to detect biomarkers in human blood and tissue samples, and NanoString nCounter tissue mRNA detection platform is under preparation
Feature Platform
  • Kinase Screening PlatformEnzymatic/Molecular Interaction Screening PlatformCell Screening PlatformSmall Nucleic Acid Platform
Structural Biology

Our Structural Biology Laboratory is equipped with molecular cloning room and a drug discovery and selection solution based on protein crystallography, supporting drug development based on structures and from new targets determination to final structural determination.

Our structural biology solution is one of the earliest established structural biology laboratories in China, and has been recognized as providing an important new drug R&D solution by the Shanghai Municipal People's Government.

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Cell Biology

Medicilon can offer Cell Assay Analysis and Radioisotope Analysis for clients.

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High Throughput Screening

Medicilon has strong capability in assay development and compound screening.Our screening capacity could be 200x384 well/week,or customize it per clients' needs.

We work closely with partners such as Selleck,MCE and Tocris that provide compound libraries, and we have more than a library of 3000 compounds in-house.

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Enzymology & Molecular Interactions

Medicilon Biology Department has rich experience in the field of in vitro biology, and offers a complete set of biological services including enzyme level measurement, cell level measurement, cell biology, biochemistry, isotope measurement in vitro, establishment of stable cell lines, gene knockout, RNAi and MicroRNA technology.

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Antibody Discovery

Antibody discovery technology plays a vital role in drug development, mainly discovering antibodies with specific binding activity by screening antibody libraries or antibodies obtained from animal immunization. This can help researchers accelerate the drug development process. It can also help researchers better understand diseases, including disease pathogenesis and discovering new therapeutic targets.

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Translational Medicine

Medicilon translational medicine platform is committed to providing global partners with comprehensive biomarker discovery, target integrated solutions for point-of-care verification, companion diagnostic development, and commercial testing.

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In Vitro Activity Assays

Medicilon has established an in vitro activity assay platform with more than 400 cell models and more than 200 in vitro enzyme assay methods. Medicilon provides cell activity assay services, SPR assay services and in vitro enzyme activity assay services.

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3D Cultured Spheroid Models
For cancer drug efficacy evaluation, Medicilon has developed 3D cel culture models with KRAS cell lines and associated diseases. Utilizing Medicilon's Ready-to-Use KRAS 3D Spheroid Models can enhance your preclinical research.
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Cell Viability Assay
In vitro biological activity detection is a mandatory item for clinical application of biological products, with high requirements for method development, personnel operation stability, and laboratory compliance management. Medicilon's cell viability assay platform can provide compliant in vitro cell viability detection services that meet the application requirements. Our high-level scientific research team can assist customers in participating in new drug development and exploring drug action mechanisms, while our high-throughput screening platform can help customers conduct efficient drug screening.
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SPR Assay
Biacore 8K can detect almost all biomolecules from various organic small molecules, peptides, proteins, nucleic acids, carbohydrates, lipids, phages, viruses and cells. Biacore 8K can also be used to study the interaction network composed of different molecules, complex assembly, protein conformational changes, thermodynamic parameters of molecular binding, and post-translational modifications of proteins. Biacore 8K provides high-quality analytical data, thereby effectively solving related problems in the current life science field.
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In Vitro Enzyme Activity Assay
Kinases play extensive and important roles in signal transduction and co-ordination of complex functions. Currently, about 300 kinase inhibitors have been approved for marketing, among which receptor tyrosine kinase (RTK) inhibitors are the main ones. Medicilon provides high-quality kinase profile screening and has one-stop kinase research services from assay development, high-throughput screening to selectivity analysis. In addition, Medicilon provides many other enzyme activity screens.
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Anti-drug Antibody Preparation

Medicilon has rich experience in ADA development and has successfully delivered more than 100 projects. Medicilon can provide high-affinity and specific polyclonal anti-drug antibody development services with short development cycles and low costs.

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