Address: 50 Soldiers Field Place, Boston, MA 02135 (America)
Tel: +1(626)986-9880
Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK
Tel: 0044 7790 816 954
Email: marketing@medicilon.com
Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)
Postcode: 201299
Tel: +86 (21) 5859-1500 (main line)
Fax: +86 (21) 5859-6369
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Business Inquiry
Global：
Email:marketing@medicilon.com
+1(626)986-9880(U.S.)
0044 7790 816 954 (Europe)
China：
Email: marketing@medicilon.com.cn
Tel: +86 (21) 5859-1500
Our Biology Department boasts a variety of technical solutions, professional scientific research teams, various advanced instruments and biological laboratories. Medicilon has broad experience in fields such as molecular biology, cell biology, in vitro biology, and structural biology.
With our technical platforms such as enzyme level and cell level measurement platforms, we can enable our clients to select compounds and research their properties, action mechanism and provide bio-marker analysis, thus ensuring the effective implementation of our clients' projects and helping promote the process of drug R&D.
Biology Service Model & Advantages
Feature PlatformPROTAC (proteolysis-targeting chimera) are bifunctional specific small molecules that can target otherwise undruggable target proteins for degradation, thereby reducing their biological activity in a cell. It can be understood as a dumbbell-shaped chimera, of which one end is used to target the target protein to be degraded, the other end is used to recruit protein degradation systems like E3 ubiquitin ligase and both ends are connected by a suitable linker. Therefore, a ternary chimera is formed featuring target protein - PROTAC - E3 ubiquitin ligase that ensures close connection between target protein and E3 ligase, so that the target protein can be ubiquitinated and then further recognized and degraded by proteasome.
In theory, this new mechanism can target all drug target proteins, especially those previously thought to be undruggable, thus expanding the field of drug research and promising prospects for new drugs R&D. PROTAC technology is novel and has many advantages compared with traditional micromolecule drugs, antibody drugs, RNAi.. It is considered one of the most popular new modalities in drug discovery and Medicilon is highly experienced in PROTAC development.
Monoclonal antibodies include an antigen-binding fragment (Fab) and a fragment crystallizable region (Fc). The Fab can bind to a tumor-associated antigen, while the Fc plays an important role in metabolic pathways, as well as in IgG-driven cellular functions.
The molecular sequence and subtype of antibodies will affect the effector functions. Such effector functions include the antibody dependent cellular cytotoxicity (ADCC) triggered by Fc binding to the FcγRIII receptor (CD16A) of NK. The Fc can also bind with serum complement molecules (C1q) to form a membrane attack complex (MAC) that triggers complement-dependent cytotoxicity (CDC). When Fc binds with macrophage receptors—namely FcγRIII (CD16A), FcγRII (CD32A) and FcγRI (CD64)—antibody-dependent cellular phagocytosis (ADCP) is triggered.
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