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Biology Research

Biology Research

Our Biology Department boasts a variety of technical solutions, professional scientific research teams, various advanced instruments and biological laboratories. Medicilon has broad experience in fields such as molecular biology, cell biology, in vitro biology, and structural biology.

With our technical platforms such as enzyme level and cell level measurement platforms, we can enable our clients to select compounds and research their properties, action mechanism and provide bio-marker analysis, thus ensuring the effective implementation of our clients' projects and helping promote the process of drug R&D.

Biology Service Model & Advantages
  • biology.wenp
    biology.wenp
    Biology Division has been dedicated to drug discovery services for over 19 yearsServing over 300 clients annuallyOver 1000 screening methods established, generating over 2 million data points per yearConducted conformational studies for more than 200 targetsCell library with over 400 tumor cell lines for drug sensitivity testingRich knowledge base with more than 50 new experimental methods and 5 new platforms per yearClinical biomarker detection system has been gradually improved, with the ability to detect biomarkers in human blood and tissue samples, and NanoString nCounter tissue mRNA detection platform is under preparation
Feature Platform
  • Kinase Screening PlatformEnzymatic/Molecular Interaction Screening PlatformCell Screening PlatformSmall Nucleic Acid Platform
Computational Biology & Molecular Modeling

In addition to the traditional biological research methods, Medicilon has developed faster and more effective tools. Using computers and big data to assist in early drug R&D, we reduce the workload of drug researchers, reduce the cost of drug development and shorten cycles of drug development.

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CHO Cell Protein Expression System
Featuring protein folding and post-translational modification, mammalian protein expression systems can make proteins that are closer to the natural proteins, thus obtaining the same biological activity and characteristics. Therefore, the mammalian cell expression system has been widely applied in the R&D and production of recombinant protein drugs, especially therapeutic recombinant monoclonal antibody drugs.
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Insect Cell Protein Expression System
The baculovirus expression vector system (BEVS) has been widely used in the preparation of various recombinant proteins since 1983, especially in the expression of recombinant kinases and protein complexes. Our researchers have developed mature baculovirus-insect cell expression service that includes the preparation of recombinant baculoviruses, and the expression and purification of recombinant proteins and protein complexes.
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Yeast Protein Expression System
Widely used in the production and preparation of recombinant proteins, especially eukaryotic proteins, the yeast expression system has the advantage of both prokaryotic and advanced eukaryotic systems. It is characterized by common culture conditions, fast growth, low cost, capability of post-translational processing of protein, and easy access to soluble active recombinant protein. Pichia pastoris has become the preferred yeast of choice ffor expressing recombinant proteins due to its rapid growth, abundant commercial expression vectors, and high-efficiency secretory expression.
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E.Coli protein expression system
Prokaryotic expression system (E.coli expression system) is a classical expression system developed earlier and widely used in gene expression technology. In recent decades, E.coli expression system has been continuously developed and improved, and has been widely used by scientific research and industrial users to express various recombinant proteins. Compared with other expression systems, it is characterized by the high expression level of target gene, short culture period, strong anti-pollution ability and low cost.
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