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Cardiovascular Model

Cardiovascular Model

Medicilon has established many cardiovascular models including the Dyslipidemia, Thrombosis & anemia, MCAO, and Anemia models for pharmacodynamics research.
DiseaseTypeSpecies
ThrombusBleeding time (BT), Coagulation time (CT)Mouse
Arteriovenous bypass thrombosis modelMouse/Rat
Rat model of deep vein thrombosisRat
Carotid artery thrombosis model Mouse/Rat
Caudal vein thrombosis induced by carrageenanMouse
Middle Cerebral Artery Occlusion(MCAO)Cerebral ischemia reperfusionMouse/Rat
Time window for treatment of cerebral ischemia reperfusion injuryMouse/Rat
The neuroprotective effect of cerebral ischemia reperfusionMouse/Rat
Permanent cerebral infarction modelMouse/Rat
AnemiaHypoferric anemiaRat
Renal anemia induced by 5/6 NephrectomyRat
Renal anemia induced by adenineRat
  • Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and hypertension. Medicilon has established rat and mouse MCAO model evaluation system with stable lesions, high success rate, high survival rate and reliable and effective evaluation of dose-effect/time-effect relationship. We can provide efficacy evaluation of transient cerebral ischemia and permanent cerebral ischemia and complete the investigation of various pharmacodynamic core indicators according to STAIR technical guidelines. The model rodents could be customized with special diseases and complete activity evaluations according to customer requirements.

    Disease Name

    ICD 10

    Model

    Intracerebral hemorrhage

    I60-I62

    Intracranial autologous blood injection, subarachnoid hemorrhage

    Cerebral infarction

    I63

    Ischemic stroke model

    Stroke

    I64

    Cerebral Embolism

    I65

    Cerebral Embolism

    I66

    Other

    I67-I69

    Other

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