Cardiovascular Model

Medicilon has established many cardiovascular models including the Dyslipidemia, Thrombosis & anemia, MCAO, and Anemia models for pharmacodynamics research.

Disease	Type	Species
Thrombosis & anemia model	Arteriovenous bypass thrombosis	Mouse/Rat
	Tail vein thrombosis in mice caused by carrageenan	Mouse
	Deep vein thrombosis in rats	Rat
	Carotid artery thrombosis	Mouse/Rat
	Coagulation time measurement	Mouse
	Renal failure induced anemia model in rats	Rat
	Iron deficiency anemia model	Rat
MCAO Model	Cerebral ischemia-reperfusion model	Mouse/Rat
	Study of the time window of cerebral ischemia-reperfusion	Mouse/Rat
	Study of neuroprotective effect of cerebral ischemia/reperfusion	Mouse/Rat
Anemia Model	Iron deficiency anemia model	Rat
	Nephrectomy (5/6) induced nephrogenic anemia model	Rat
	Adenine induced renal anemia model	Rat
Dyslipidemia	High-fat/cholesterol/fructose diet-induced hyperlipidemia model	Hamster
Dyslipidemia	Hereditary atherosclerotic APOE mice + high-fat feeding	APOE Mouse

Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and hypertension. Medicilon has established rat and mouse MCAO model evaluation system with stable lesions, high success rate, high survival rate and reliable and effective evaluation of dose-effect/time-effect relationship. We can provide efficacy evaluation of transient cerebral ischemia and permanent cerebral ischemia and complete the investigation of various pharmacodynamic core indicators according to STAIR technical guidelines. The model rodents could be customized with special diseases and complete activity evaluations according to customer requirements.

Disease Name	ICD 10	Model
Intracerebral hemorrhage	I60-I62	Intracranial autologous blood injection, subarachnoid hemorrhage
Cerebral infarction	I63	Ischemic stroke model
Stroke	I64
Cerebral Embolism	I65
Cerebral Embolism	I66
Other	I67-I69	Other

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