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Cardiovascular Model

Cardiovascular Model

Medicilon has established many cardiovascular models, which contain Dyslipidemia model, Thrombosis & anemia model, MCAO model, and Anemia model for pharmacodynamics research.
DiseaseTypeSpecies
Thrombosis & anemia modelArteriovenous bypass thrombosisMouse/Rat
Tail vein thrombosis in mice caused by carrageenanMouse
Deep vein thrombosis in ratsRat
Carotid artery thrombosis Mouse/Rat
Coagulation time measurementMouse
Renal failure induced anemia model in ratsRat
Iron deficiency anemia modelRat
MCAO ModelCerebral ischemia-reperfusion modelMouse/Rat
Study of the time window of cerebral ischemia-reperfusionMouse/Rat
Study of neuroprotective effect of cerebral ischemia/reperfusionMouse/Rat
Anemia ModelIron deficiency anemia modelRat
Nephrectomy (5/6) induced nephrogenic anemia modelRat
Adenine induced renal anemia modelRat

Dyslipidemia

High-fat/cholesterol/fructose diet-induced hyperlipidemia modelHamster
Hereditary atherosclerotic APOE mice + high-fat feedingAPOE Mouse
  • Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and hypertension. Medicilon has established rat and mouse MCAO model evaluation system with stable lesions, high success rate, high survival rate and reliable and effective evaluation of dose-effect/time-effect relationship. We can provide efficacy evaluation of transient cerebral ischemia and permanent cerebral ischemia and complete the investigation of various pharmacodynamic core indicators according to STAIR technical guidelines. The model rodents could be customized with special diseases and complete activity evaluations according to customer requirements.

    Disease Name

    ICD 10

    Model

    Intracerebral hemorrhage

    I60-I62

    Intracranial autologous blood injection, subarachnoid hemorrhage

    Cerebral infarction

    I63

    Ischemic stroke model

    Stroke

    I64

    Cerebral Embolism

    I65

    Cerebral Embolism

    I66

    Other

    I67-I69

    Other

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