CDX Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models created by implanting cancer cell lines into immunodeficient mice have contributed largely to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice.

After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to the long-term cell passage in vitro, they have the characteristics of high homology, easy construction, and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.