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CDX Models

CDX Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models are created by implanting cancer cell lines into immunodeficient mice and have contributedsignificantly to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice.

After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to long-term cell passage in vitro, cells have the characteristics of high homology and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.

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medicilon icon-diamond.pngModel Type
Cancer TypeCell Lines
Breast cancer2LMP, Bcap-37, BT-474, HCC1806, HCC70, HCC1569, HCC1954, HCC70, JIMT-1, MCF-7, MDA-MB-231, MDA-MB-468, MX-1, SUM149PT, ZR-75-1
Bladder cancerMDA-MB-231, MDA-MB-361, MDA-MB-468, MX-1, SUM159, SUM149PT, ZR-75-1, ZR-75-30, HT-1197, HT-1376, RT4, SCaBER, SW780, T24
Colon and cecum cancerCOLO 201, COLO 205, COLO 320 DM, CW-2, DLD-1, HCT-8, HCT-15, HCT-116, HT-29, LoVo, LIM-1215, Ls174T, NCI-H580, RKO, SW480, SW620
Cervical cancerLS1034, LS174T, LS411N, LIM-1215, NCI-H716, NCI-H508, RKO, SW48, SW620, SiHa, Hela
Endometrium/HysterocarcinomaAN3 CA, HEC-1-A, ME-180, MFE-280
FibrosarcomaHT-1080
Gastric cancerBGC-823, HGC-27, MKN-45, MKN-28, NCI-N87, NUGC-3, SCH, SGC-7901, Hs 746T, SNU-16
GlioblastomaU-87MG, U-87 MG-Red-Fluc(PE), LN-229
Hepatocellular cancerBel-7402, Hep-3B, Huh-7, PLC/PRF/5, QGY-7703, SK-HEP-1, SMMC-7721
Head and neck cancerFaDu, Detroit 562, CAL-27
Lung cancer95-D, A-549, Calu-1, Calu-3, Calu-6, DMS114, HCC827, MSTO-211H, NCI-H1299, NCl-H146, NCI-H1581, NCI-H1650, NCI-H1688, NCI-H1975, NCl-H209, NCI-H2122, NCI-H2228, NCI-H226, NCI-H292, NCI-H3122, NCI-H358, NCI-H446, NCI-H460, NCI-H520, NCI-H526, NCI-H69, NCI-H727, PC-9
LeukemiaCCRF-CEM, HEL, HL-60, K-562, Karpas-299, MV-4-11, MOLT-4, MOLM13, THP-1
Muscle, StriatedSJCRH30
MyelomaKMS-11, KMS-26, RPMI-8226, MM.1S, NCI-H929
MelanomaA375, A2058, C32, HMCB, MDA-MB-435s, SK-MEL-30, WM-226-4
Ovarian cancerES-2, HO-8910PM, PA-1, SK-OV-3, OVCAR-3, A2780
Oral epithelial cancerKB
OsteosarcomaMG-63, SJSA-1
Prostate cancerDU145, PC-3, LNCap, CL-1
Pancreatic cancerAsPC-1, BxPC-3, Capan-1, Capan-2, CFPAC-1, HPAF-II, Mia PaCa-2, PANC-1, SU.86.86
PharynxFaDu
Renal cancerACHN, OS-RC-2, 786-O, A498
Skin cancerA431, Colo829
Thyroid gland medullaryTT
LymphomaSU-DHL-4, DB, SU-DHL-6, Mino, Daudi, JeKo-1, Raji, TMD-8, WSU DLCL2, DOHH2, OCI-LY19, OCI-HL10, MOLM13, U-937
Liver cancerHep G2, HuH-7
Brain cancerU-87 MG, LN-229, SH-SY5Y
Relevant laboratories
  • BD FACSymphoy A3
  • BD FACSCelesta flow cytometer-12 channels
  • IVIS SPECTRUM 3D imager for small animals
  • Operating Room (Microscope)
  • Details of IVIS SPECTRUM 3D imager for small animals
  • RAD SOURCE Small Animal X-ray irradiator
  • Operating Room
  • BD LSRFortessa flow cytometer -18 channel
Relevant articles