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CDX Models

CDX Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models are created by implanting cancer cell lines into immunodeficient mice and have contributedsignificantly to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice.

After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to long-term cell passage in vitro, cells have the characteristics of high homology and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.

medicilon icon-diamond.pngModel Type
Cancer TypeCell Lines
Brain cancerU-87 MG, LN-229, SH-SY5Y
Breast cancerBT474, HCC1569, HCC1954, HCC70, JIMT-1, MCF7, MDA-MB-231, MDA-MB-468, MX-1, SUM149PT, ZR-75-1
Colon cancerCOLO 205, DLD-1, HCT-116, HCT-15, HT-29, LIM-1215, LoVo, Ls174T, NCI-H580, RKO, SW480, SW620
EndometriumAN3 CA, HEC-1-A
Gastric cancerHs 746T, MKN-45, NCI-N87, SNU-16
Head and neck cancerTT, FaDu
LeukemiaCCRF-CEM, HEL, HL-60, K-562, MV-4-11, THP-1
Liver cancerHep G2, HuH-7
Lung cancerA549, Calu-1, Calu-3, Calu-6, HCC827, MOTO-211H, NCI-H1299, NCI-H1650, NCI-H1975, NCI-H2122, NCI-H358, NCI-H460, NCI-H520, NCI-H2228, NCI-H526, NCI-H69, NCI-H727, PC9, A427
LymphomaSU-DHL-4, DB, SU-DHL-6, Mino, Daudi, JeKo-1, Raji, TMD-8, WSU DLCL2, DOHH2, OCI-LY19, OCI-HL10, MOLM13, U-937
MyelomaMM.1S, NCI-H929, RPMI-8226
Ovarian cancerA2780, OVCAR-3, SK-OV-3
Pancreatic cancerAsPC-1, Bx PC-3, Capan-1, Capan-2, CFPAC-1, HPAF-II, Mia PaCa-2, PANC-1, SU.86.86
Prostate cancerDU145, PC-3
Renal cancer786-O, OS-RC-2, A498
Skin cancerA-431
Relevant laboratories
  • BD FACSymphoy A3
  • BD FACSCelesta flow cytometer-12 channels
  • IVIS SPECTRUM 3D imager for small animals
  • Operating Room (Microscope)
  • Details of IVIS SPECTRUM 3D imager for small animals
  • RAD SOURCE Small Animal X-ray irradiator
  • Operating Room
  • BD LSRFortessa flow cytometer -18 channel
Relevant articles