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Discovery Biology Services

Home Service Discovery Biology Services

Our Discovery Biology department offers services supporting structure-based drug discovery from determination of novel targets to final structures. Our platform is one of the earliest established structural biology platforms in China and has been certified by the Shanghai Government.

Biochemical Assay

Technology Platforms

  • Fluorescence: Lance; Alphascreen; Z’-LYTE ; HTRF,TR-FRET,FP etc
  • Luminescence: Kinase-Glo; ADP-Glo etc
  • Absorbance: UV; VI

Kinase Assay: VEGFR2 I

Biology Discoveries-Kinase Assay

Protease Assay: Renin inhibition using FRET

Biology Discoveries-Protease Assay

Validated Biochemical Assay List

Validated Enzymatic Targets

Abl

AKT1

AKT2

AKT3

ALK

Aurora A

Aurora B

B-Raf

BTK

Cathepsin K/L/B/S

CDK/P25

CHK1

CHK2

c-Kit

c-Met

COX-1/COX-2

C-Raf

DPPIV

EGFR

EGFR (L858R/T790M)

Factor Xa

FGFR1

Flt1/VEGFR1

Flt3

Flt4

α- Glucosidase

β- Glucosidase

GSK3 beta

H+/K+ ATPase

HDAC1 &HDACs

HER2

IKK beta

JAK1

JAK2

JAK3

LCK

Lipoxygenase

Lyn

MAPK14

MARK1

MEK1

MEK2

mTOR

PDE5

PDGFR beta

PI3K alpha

PI3K beta

PI3K delta

PI3K gamma

PKA

PKC delta

PKC gamma

Plk1

20S proteasome

Renin

SAHase

SGK1

SRC

Syk

VEGFR2

Note: The enzyme in blue is Kinase

Cellular-based Assay

Technology Platforms

  • Cytotoxicity Assay
  • Apoptosis Assay
  • Cell Migration Assay
  • Cell Invasion Assay
  • Immunostaining Assay
  • Immunofluorescence Assay (96/384 wells)
  • Reporter Gene Assay (GFP/Luc)
  • Cellular Uptake Assay
  • Gene Knockdown Assay
  • RNAi Assay
  • MicroRNA Over-expression Assay
  • MicroRNA Knockdown Assay
  • Adenovirus/retrovirus/lentivirus

Cytotoxicity Assay Using celltiter glo

Discovery Biology Services

Cell-based Cathepsin Assay for irreversible inhibitors
Discovery Biology

Cell Cycle Analysis Using Flow Cytometry

Discovery Biology Service

Western Blot Analysis

Expression level of Phospho-Akt and Akt in mouse tumor

Biology Services in Discovery

Migration Assay in HT1080 cells and MDA-MB-231 cells

Cytotoxicity Assay Using celltiter glo
Biology Services Medicilon

Cell-based Cathepsin Assay for irreversible inhibitors
Discovery Biology Services in Medicilon

Pre-migration
Migration Assay Pre-migration

Post-migration
Migration Assay Post-migration

Background
Migration Assay Background

Positive control
Migration Assay Positive control

Radioactive Assay

Technology Platforms (3H, 33P, 32P, 35S, 125I,14C)

  • Radioactive Receptor Binding Assay
  • Radioligand Binding Assay
  • Radioactive Uptake Assay
  • Cell Proliferation Assay (3H-TdR)
  • Radioimmunoassay (RIA)
  • Immunoradiometric Assay (IRMA)

Receptor binding assay-3H
Receptor binding assay-3H

3H-5HT uptake assay-3H
3H-5HT uptake assay-3H

Radioactive iodine uptake assay-125I

Radioactive iodine uptake assay-125I

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  • Formulation Development
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  • Integrated Projects

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About Us

  • Medicilon Overview
  • Executive Team
  • CEO Message
  • Company History
  • Corporate Culture
  • Honor

Services

  • Chemistry
  • Biology
  • Bioanalytical
  • Drug Safety Evaluation
  • Formulation Development
  • Pharmacology
  • Pharmacokinetic
  • Integrated Projects

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Shanghai Medicilon Inc.

Address: No. 585, Chuanda Road, Pudong, Shanghai, 201200, China
Email: Marketing@medicilon.com
Website: www.medicilon.com

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  • Home
  • About
    • Medicilon Overview
    • Executive Team
    • CEO Message
    • Corporate Culture
    • Company History
    • Honor
  • Services
    • Integrated Projects
      • Antibody-Drug-Antibody (ADC)
      • Preclinical Research Services
      • IND Filing
      • Bio Drug Development
      • Chemical Drug Development
      • Chemical Compound Druggability Assessment
      • Molecular Imaging & Radiochemistry
      • OINDP Development
      • Preclinical Ophthalmic Research Platform
    • Pharmacology Services
      • Cancer Xenograft Models
      • Orthotopic Models
      • Syngeneic Mouse Models
      • Transgenic Mouse Model
      • Humanized Mouse Model (hPBMCEngrafted)
      • PDX Model
      • Digestive System Models
      • Neurological Disorders Models
      • Metabolic Disease Models
      • Inflammation & Immunological Disease Models
      • Other Disease Models
    • Chemistry Services
      • Medicinal Chemistry Services
      • Synthetic Chemistry
      • Process Development Services
      • Analytical Chemistry
    • Drug Formulation
      • Pre Formulation Development
      • Analytical Development
      • Formulation Development Services
      • Generics Consistency Evaluation
      • Research on Quality Control
      • Clinical Trial Material
      • OINDP Development
    • Biology Services
      • Discovery Biology Services
      • Recombinant Protein Services
      • Computational Biology & Molecular Modeling
      • Crystallization & Structural Determination
      • Kinase Services
      • SeMet Media Sales
    • Bioanalytical Services
      • Large Molecule Bioanalysis
      • Small Molecule Bioanalysis
    • Pharmacokinetic Services
      • In Vivo Assays
      • In Vitro Assays
    • Drug Safety Evaluation
      • Inhalation Toxicity Assessment
  • Customer
    • Customer Reviews
    • New Models of Collaboration
    • Intellectual Property Protection
    • Download Center
  • Careers
  • News
    • Medicilon Events
    • Media Coverage
    • Featured Stories
  • Contact
Medicilon Inc