Enzyme Catalysis
As a CRO that advocates green drug research and development, Medicilon has always been committed to promoting the green upgrading of pharmaceutical processes through technological innovation. Medicilon has already used enzymes in process research and development, and relying on its strong chemical and biological background, Medicilon has established a the Enzyme Catalysis Technology Platform to screen catalytic enzymes for specific reaction types and establish corresponding enzyme libraries to assist process development and production.
Medicilon Enzyme Catalysis Service Platform
01 Chemical Technology Platform
Development of Pharmaceutical Intermediates and APls
Functional Chemical Development
02 Biotechnology Platform
Enzyme Development and Applications
Enzyme Production
03 Quality Technology Platform
Quality and Control Research
Inspection and Testing Services
Medicilon's Enzyme Catalysis Technology Platform includes chemical technology platform, biotechnology platform, and quality technology platform. The platform focuses on the combination of chemical synthesis and biological enzyme catalytic synthesis, the development and application research of biological enzymes, and the R&D and production of pharmaceutical intermediates and APIs using green biotechnology. At the same time, it provides high-end CRO, CDMO services, testing and quality research services to pharmaceutical companies.
Medicilon Enzyme Library
| Ketoreductase | D-amino acid dehydrogenase | Transaminase | Nitrile Hydratase | Phenylalanine Lyase | Hydroaminase |
| Cytochrome Monooxygenase | Threonine Dehydrogenase | Phosphokinase | Epoxide Hydrolase | | Nitrilase |
| Alcohol Oxidase | Formate Dehydrogenase | Nucleoside Phosphorylation (synthesis) | Amidohydrolase | | Aldol Condensase |
| Monoamine Oxidase | Glucose Dehydrogenase | | Nitrilase | | Other Specialized Enzymes |
| Nitrile | Lactate | | | Lactate | |
| Reductase | Dehydrogenase | | | Dehydrogenase | |
| Nitroreductase | Phenylalanine Dehydrogenase | | | | |
| Imine Reductase | Ammonia Dehydrogenase | | | | |
At present, Medicilon has successfully established dozens of major biological enzyme libraries, such as ketoreductase, ester hydrolase, imine reductase, nitroreductase, cyclooxygenase, amide hydrolase, for providing suitable biocatalytic solutions for various chemical transformations. These integrated enzymatic services reduce costs, shorten time, and improve quality. With the implementation of a large amount of projects, Medicilon enzyme library is also continuing to be optimized and expanded. Medicilon will also carry out research on immobilized enzymes and coenzymes.
Medicilon’s R&D capabilities in the field of synthetic biology
With the continuous advancement of synthetic biology technology, more and more enzymes with specific catalytic functions are used as biocatalysts to achieve reactions that are difficult to achieve with chemical catalysts, and can be used as catalytic components to build functional modules of synthetic biology. Medicilon has already established a presence in the field of synthetic biology. Through the assembly of different enzyme components, Medicilon has made breakthroughs in the design of synthetic routes for many target molecules and can provide a variety of services:
Molecule and Strain ConstructionStrain Delection and DomesticationEnzyme Co-ExpressionMulti-Enzyme CatalysisBiocatalysisProtein ModificationFermentation MetabolismProtein PurificationFermentation OptimizationEnzyme Immobilization
In the future, Medicilon, as a one-stop biopharmaceutical preclinical R&D service platform, will continue to explore and apply more innovative green chemical technologies to achieve more environmentally friendly, safe, efficient and economical process development and production, and create more innovative products for global clients.
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