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Preclinical Research

Humanized Mouse Models

Humanized mice can easily simulate the biological characteristics of human beings. They are very important for the establishment of preclinical pharmacodynamic evaluation models, and can provide suitable pharmacodynamic models for testing biotechnology drugs such as antibodies or antibody drug conjugates (ADCs).
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Medicilon icon-diamond.pngModel Type
  • PBMC Humanized Models
    The humanized mouse model of local human immune system is particularly effective for short-term research or high-throughput research.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Brain CancerU-87 MG
    Breast CancerHCC1954, MDA-MB-231, JIMT-1
    Colon CancerHT29, LoVo, Ls174T
    Gastric CancerNCI-N87
    LeukemiaTHP-1
    Lung CancerHCC827, NCI-H1975, NCI-H292, A549
    LymphomaRaji, TMD8, MOLM-13
    MelanomaA375
    Myeloma
    RPMI-8226, NCI-H929, MM.1S
    Ovarian Cancer
    OVCAR-3
    Pancreatic Cancer
    Capan-2
    Renal Cancer
    786-O
    Skin Cancer
    A431
    Bladder cancerUM-UC-3
    Prostate
    PC-3
    Pharynx
    FaDu
    Liver
    Hep G2
    Thyroid / medulla
    TT
    Uterus; endometrium
    Ishikawa
    Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma model.png
  • CD34+ HSC Humanized Models
    The CD34+ HSC humanized models with transplanted human umbilical cord blood cells-reconstructed hemopoietic system is implanted in the bone marrow of mice, and can produce various kinds of humanized hematopoietic cells and immune cells constantly and stably. All kinds of immunotherapy will be evaluated by the human immune system.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Breast cancerHCC1954
    Colon cancer
    HT29, Lovo, Ls174T
    Lung cancer NCI-H292, HCC827
    LeukemiaTHP-1
    LymphomaRaji, MOLM-13
    MyelomaNCI-H929
    Skin cancerA431
    Ovarian CancerOVCAR-3
    CD34+ HSC Humanized Models.png
Relevant laboratories
  • RAD
  • FCM
  • 病理切片
  • FCM
  • IVIS-Lumina-III-In-Vivo-Imaging-System
  • 冰冻切片
  • 病理观察
  • 操作室-外室
  • 冰冻切片
  • 病理切片
  • 流式细胞仪
  • 动物饲养室
  • 操作室-外室
  • 药效实验室
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