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Humanized Mouse Models

Humanized Mouse Models

Humanized mice can simulate key biological characteristics of human beings, and they are very useful for establishing preclinical pharmacodynamic evaluation models. They can provide suitable pharmacodynamic models for testing protein-derived drugs such as antibodies or antibody-drug conjugates (ADCs).
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Medicilon icon-diamond.pngPBMC + CD34+ HSC Humanized Models
  • Model Types
    The humanized mouse model of the local human immune system is particularly effective for short-term or high-throughput research.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Brain CancerU-87 MG
    Breast CancerHCC1954, MDA-MB-231, JIMT-1
    Colon CancerHT29, LoVo, Ls174T
    Gastric CancerNCI-N87
    LeukemiaTHP-1
    Lung CancerHCC827, NCI-H1975, NCI-H292, A549
    LymphomaRaji, TMD8, MOLM-13
    MelanomaA375
    Myeloma
    RPMI-8226, NCI-H929, MM.1S
    Ovarian Cancer
    OVCAR-3
    Pancreatic Cancer
    Capan-2
    Renal Cancer
    786-O
    Skin Cancer
    A431
    Bladder cancerUM-UC-3
    Prostate
    PC-3
    Pharynx
    FaDu
    Liver
    Hep G2
    Thyroid / medulla
    TT
    Endometrium cancer
    Ishikawa
    Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma model.png
  • Preparation
    Preparation-method-of-reconstituted-PBMC-humanized-tumor-transplantation-model-in-mice.webp
  • Pharmacodynamic Evaluation
    Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma transplantation model.webp
    Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma transplantation model
    Efficacy study using Raji-luc cells in hPBMC humanized model.webp
    Efficacy study using Raji-luc cells in hPBMC humanized model
CD34+ HSC humanized tumor xenograft model
  • Model types
    CD34+ HSC humanized models with transplanted human umbilical cord blood cells- can produce various kinds of humanized hematopoietic cells and immune cells reproducibly and stably. Diverse modes of immunotherapy can be evaluated using this humanized immune system model.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Brain CancerU-87 MG
    Breast Cancer
    HCC1954, MDA-MB-231, JIMT-1
    Colon Cancer HT29, LoVo,
    Gastric CancerNCI-N87
    LymphomaRaji, TMD8, MOLM-13
    MyelomaRPMI-8226, NCI-H929
    Pancreatic CancerCapan-2
    Skin CancerA431
  • Preparation
    CD34+-HSC-humanized-tumor-xenograft-model-preparation.webp
  • CD34+ Model Validation
    CD34+ Model Validation.webp
Relevant laboratories
  • RAD
  • FCM
  • pathological section
  • FCM
  • IVIS-Lumina-III-In-Vivo-Imaging-System
  • frozen section
  • pathological observation
  • Operation room - outer room
  • frozen section
  • flow cytometer
  • Animal feeding room
  • Operation room - outer room
  • Pharmacodynamic Laboratory
Relevant articles