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Preclinical research
Humanized Mouse Models
Humanized mice can easily simulate the biological characteristics of human beings. They are very important for the establishment of preclinical pharmacodynamic evaluation models, and can provide suitable pharmacodynamic models for testing biotechnology drugs such as antibodies or antibody drug conjugates (ADCs).
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Model Type
  • PBMC Humanized Models
    The humanized mouse model of local human immune system is particularly effective for short-term research or high-throughput research.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Brain CancerU-87 MG
    Breast CancerHCC1954, MDA-MB-231, JIMT-1
    Colon CancerHT29, LoVo, Ls174T
    Gastric CancerNCI-N87
    LeukemiaTHP-1
    Lung CancerHCC827, NCI-H1975, NCI-H292, A549
    LymphomaRaji, TMD8, MOLM-13
    MelanomaA375
    Myeloma
    RPMI-8226, NCI-H929, MM.1S
    Ovarian Cancer
    OVCAR-3
    Pancreatic Cancer
    Capan-2
    Renal Cancer
    786-O
    Skin Cancer
    A431
    Kidney

    Bone marrow 

    Prostate

    Pharynx

    Liver

    Thyroid / medulla

    Urinary bladder

    Cecum

    Connective tissue

    Uterus; endometrium

    Large intestine; Colon

    Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma model
  • CD34+ HSC Humanized Models
    The CD34+ HSC humanized models with transplanted human umbilical cord blood cells-reconstructed hemopoietic system is implanted in the bone marrow of mice, and can produce various kinds of humanized hematopoietic cells and immune cells constantly and stably. All kinds of immunotherapy will be evaluated by the human immune system.
    Currently, we have the following model types available:
    Cancer TypeCell Lines
    Cerebral cancerU-87 MG
    Breast cancerHCC1954, MDA-MB-231 and JIMT-1
    Colon cancerHT29 and LoVo
    Gastric cancerNCI-N87
    Lung cancerHCC827, NCI-H1975, NCI-H292 and A549
    LymphomaRaji, TMD8 and MOLM-13
    MyelomaRPMI-8226 and NCI-H929
    Pancreatic cancerCapan-2
    Skin cancerA431
    Bladder cancerUM-UC-3
    CD34+ HSC Humanized Models
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