Humanized Mouse Models

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PBMC + CD34⁺ HSC Humanized Models

• Model Types
  The humanized mouse model of the local human immune system is particularly effective for short-term or high-throughput research.
  Currently, we have the following model types available:

  Cancer Type	Cell Lines
  Brain Cancer	U-87 MG
  Breast Cancer	HCC1954, MDA-MB-231, JIMT-1
  Colon Cancer	HT29, LoVo, Ls174T
  Gastric Cancer	NCI-N87
  Leukemia	THP-1
  Lung Cancer	HCC827, NCI-H1975, NCI-H292, A549
  Lymphoma	Raji, TMD8, MOLM-13
  Melanoma	A375
  Myeloma	RPMI-8226, NCI-H929, MM.1S
  Ovarian Cancer	OVCAR-3
  Pancreatic Cancer	Capan-2
  Renal Cancer	786-O
  Skin Cancer	A431
  Bladder cancer	UM-UC-3
  Prostate	PC-3
  Pharynx	FaDu
  Liver	Hep G2
  Thyroid / medulla	TT
  Uterus; endometrium	Ishikawa

  
• Preparation
  
• Pharmacodynamic Evaluation
  
  Tumor growth and drug efficacy evaluation of PBMC humanized mouse lymphoma transplantation model
  
  Efficacy study using Raji-luc cells in hPBMC humanized model

CD34⁺ HSC humanized tumor xenograft model

• Model types
  CD34⁺ HSC humanized models with transplanted human umbilical cord blood cells- can produce various kinds of humanized hematopoietic cells and immune cells reproducibly and stably. Diverse modes of immunotherapy can be evaluated using this humanized immune system model.
  Currently, we have the following model types available:

  Cancer Type	Cell Lines
  Brain Cancer	U-87 MG
  Breast Cancer	HCC1954, MDA-MB-231, JIMT-1
  Colon Cancer	HT29, LoVo,
  Gastric Cancer	NCI-N87
  Lymphoma	Raji, TMD8, MOLM-13
  Myeloma	RPMI-8226, NCI-H929
  Pancreatic Cancer	Capan-2
  Skin Cancer	A431

• Preparation
  
• CD34⁺ Model Validation
  

Relevant laboratories

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Relevant articles