Medicilon has rich experience in in vitro research on pharmacokinetics including metabolic stability, P450 induction and inhibition, metabolic pathway and metabolite identification, with animals involved including rats, mice, rabbits, dogs and monkeys.
Determination of plasma protein binding ratePlasma stability testsLiver microsomal metabolism testsCYP450 inhibition testsCYP450 induction testsMetabolite speculationMetabolite identificationEstimation of metabolic pathwayIdentification of metabolic pathwayTransmembrane transport testDrug-drug interactionMetabolic phenotype researchHepatocyte metabolic stability tests
Evaluation performance
Our Preclinical Pharmacokinetics Department can complete nearly thousands of single pharmacokinetic researches in vitro every year. The research categories involve micromolecule drugs, bio-tech-based drugs and natural product drugs.
Software
WinNolin and WastonLim are used for calculation and processing of pharmacokinetic research data and management of analytical laboratory.