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Preclinical Research

In Vitro Pharmacokinetic Assays

Medicilon has rich experience in in vitro research on pharmacokinetics including metabolic stability, P450 induction and inhibition, metabolic pathway and metabolite identification, with animals involved including rats, mice, rabbits, dogs and monkeys.
Medicilon icon-diamond.pngServices
  • Determination of plasma protein binding rate Plasma stability tests Liver microsomal metabolism tests CYP450 inhibition tests CYP450 induction tests Metabolite speculation Metabolite identification Estimation of metabolic pathway Identification of metabolic pathway Transmembrane transport test Drug-drug interaction Metabolic phenotype research Hepatocyte metabolic stability tests
Medicilon icon-notebook.pngEvaluation performance
  • Our Preclinical Pharmacokinetics Department can complete nearly thousands of single pharmacokinetic researches in vitro every year. The research categories involve micromolecule drugs, bio-tech-based drugs and natural product drugs.
Medicilon icon-bulb.pngSoftware
  • WinNolin and WastonLim are used for calculation and processing of pharmacokinetic research data and management of analytical laboratory.

Relevant laboratories
  • Pharmacokinetics
  • In Vitro Pharmacokinetic Assays
  • Pharmacokinetics refrigerator
  • Immunoassay platform
  • microscope
  • TSQ Quantum Access MAX
  • Shimadzu UV Analyzer
  • radio-tlc
  • MSD
  • Ultrasonic Disintegrator
  • Triple Quad 6500
  • Pharmacokinetic Instruments
Relevant articles