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Preclinical Research

In Vivo Pharmacokinetic Assays

Medicilon has rich experience in pharmacokinetics research. We offer a broad spectrum of high quality of services involving all micromolecule and macromolecule (protein and antibody), with service contents including in vitro ADME, in vivo pharmacokinetics and bioanalysis. The test subjects involved include non-human primates, dogs, rats/mice, rabbits and guinea pigs. Among them, the non-human primate experimental platform and the isotope platform for protein/antibody have been recognized as important laboratory platforms by Shanghai Municipal People's Government.
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Medicilon icon-diamond.pngServices
  • Haemodynamics ResearchTissue Distribution ResearchExcretion ResearchMaterial BalanceBlood Brain BarrierADC pharmacokinetic evaluation, etc.
Due to complex compositions, the PK characteristics of ADC must be evaluated by multiple analytes. Therefore, the difficulty of analysis is increased. In the in vivo assay of ADC, we have provided a variety of quality testing methos for various ADC component analytes. By analyzing plasma/serum samples collected from animals, we provide our clients with reliable and quality PK data.
DeterminandDescriptionTypical analysis method
Conjugated AntibodyAntibody conjugated to at least one drugLBA
Total AntibodyFully conjugated, partially conjugated and unconjugated antibodiesLBA
Small MoleculesFree or diluted drug micromolecules and their metabolitesLC-MS/MS
ADAAntibodies that can specifically bind ADC molecules and their partial structuresLBA
In the meantime, Medicilon has introduced an animal in vivo PET/CT/MR molecular imaging system. Through the system, the delicate and complex physiological and metabolic processes in organisms can be observed. The PET research with radio-tracer label can ensure quantitative evaluation of the pharmacokinetics and metabolism of drugs. Combined with efficacy data including ethology performance, the pharmacokinetics PET researcher can establish the dose-efficacy relationship and determine the dose while tracking the regional distribution of drugs in target tissues.
Medicilon icon-notebook.pngEvaluation performance
  • Our Preclinical Pharmacokinetics Department can complete nearly 1,000 single pharmacokinetic researches in vivo and nearly 200 complete pharmacokinetic researches in accordance with the filing every year.The research categories involve micromolecule drugs, bio-tech-based drugs and natural product drugs.The contents involved in evaluation include but are not limited to haemodynamics, tissue distribution, rxcretion and material balance.Medicilon enjoys a research license for radioisotopes (125I, 14 C, 3H). The license is for material balance and tissue distribution researches.
Medicilon icon-bulb.pngSoftware
  • WinNolin and WastonLim are used for calculation and processing of pharmacokinetic research data and management of analytical laboratory.
Relevant laboratories
  • Pharmacokinetics
  • Immunoassay Platform
  • Pharmacokinetic Instruments
  • isotope
  • Electrochemiluminescence instrument
  • high-speed centrifuge
  • Shimadzu UV Analyzer
  • Clinical testing equipment
  • Pharmacokinetics refrigerator
  • tissue embedding machine
  • LC-MS-MS
  • Tissue Dehydrator
  • Ultrasonic Disintegrator
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