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Pharmaceutical Research
Pharmaceutical Research

Intermediates

Pharmaceutical intermediates are chemical raw materials or products used in the pharmaceutical synthesis process. They effectively promote the R&D process of new and generic drugs, and some key intermediates may also become critical factors restricting process development. In compliance with the regulations and guiding principles of the ICH and NMPA/FDA, our CMC Department can provide clients with integrated pharmaceutical services, including the development of pharmaceutical intermediate production processes and the optimization of commercial production, as well as all registrations and filings.

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  • Medicilon’s services regarding intermediates or other chemical-related businesses
    Intermediate synthesis route featuring intellectual property and cost advantagesRoute selection, process optimization, quality research, and process safety evaluation Scale-up production (GMP or non-GMP) Development and validation of analytical methodsSynthetic route development, process optimization, and scale-up production for fine chemicals, especially the process development and production of some high value-added fine chemicals
  • Pharmaceutical intermediates synthesis technology
    Directional nitrificationHigh-temperature and high-pressure reaction Condensation Controlled oxidation Fluorination Hydrogenation reduction Asymmetric synthesisAsymmetric catalytic reactions (such as biocatalysis)
  • Medicilon’s pharmaceutical intermediates R&D
    The introduction, design and research of pharmaceutical intermediate productsSelection of commercial routesDevelopment and optimization of commercial processes, based on design of experiment (DoE) and quality by design (QbD)Research on unit operations and determination of key step-by-step process parametersResearch on the structure, source and control of impurities Determination of initial materials, based on GMP Timely procurement of laboratory-scale test results of pharmaceutical intermediates and pilot-scale testing so to provide a reliable technological basis for industrial productionStructural analysis and performance testing of pharmaceutical intermediates
Product List
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    Medicilon Protac intermediate product list
    NumberCompound NamePurityInventory
    13-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride97.4500 mg
    23-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride94.61.6 g
    31-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide hydrochloride94.41.3 g
    4 t-Boc-N-amido-PEG5-acid 97/
    5 t-Boc-N-amido-PEG1-acid \\
    6Pomalidomide99.8\
    72-(2,6-dioxopiperidin-3-yl)-5-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione909.5 g
    82-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid90102 mg
    9perfluorophenyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate9023 mg
    101-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidine-4-carbaldehyde90100 mg
    112-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione90200 mg
    121-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde90100 mg
    132-(2,6-dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione96.4102.08 mg
    142-(2,6-dioxopiperidin-3-yl)-4-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione94.8101.91 mg
    151-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylic acid97.7104.5 mg
    162-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride98.3103 mg
    172-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride92.46101 mg
    182-(2,6-dioxopiperidin-3-yl)-5-[4-(hydroxymethyl)-3-methylpiperidin-1-yl]isoindole-1,3-dione95.1103 mg
    192-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione97.8102 mg
    20QL12003-700-195.726 mg
    21QL12003-707-293.928 mg
    22QL12003-707-199.720 mg
    23QL12003-667-36220 mg
    24QL12003-667-199.427 mg
    25QL12003-650-163.228 mg
    26inter14-1090 mg
    27QLS12010-1058-420mg
    28QLS12003-697-327.61mg
    29QL-MDC1001-32.342 g
    30QL-MDC1001-41.680 g
    31QLS12003-504-52.02 g
    32QLS12003-605-196.3240 mg
    33QLS12003-605-299.265 mg
    34QLS12003-605-388.760 mg
    35QLS12003- inter1486.750 mg
    36QLS12003- inter1-765 mg
    37QLS12003- 563-730 mg
    38QLS12003-693-285 mg
    39QLS12003-696-293.754 mg
    40QLS12003-609-282110 mg
    41tert-butyl 4-(2-((1s,3s)-3-(benzyloxy)cyclobutoxy)ethyl)piperazine-1-carboxylate952.05 g
    42tert-butyl (3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)(methyl)carbamate98213 mg
    43tert-butyl 3-(prop-2-yn-1-yloxy)propanoate950.66 g
    44tert-butyl 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanoate951.33 g
    45tert-butyl 4-(2-((1s,3s)-3-((methylsulfonyl)oxy)cyclobutoxy)ethyl)piperazine-1-carboxylate95167 mg
    46tert-butyl (2-(3-hydroxypropoxy)ethyl)carbamate951.45 g
    475-(4-((1,4-dioxaspiro[4.5]decan-8-yl)methyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione992.83 g
    482-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((4-oxocyclohexyl)methyl)piperazin-1-yl)isoindoline-1,3-dione95740 mg
    493-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid95430 mg
    50tert-butyl 3-(2-(2-(2-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoate95760 mg
    513-(2-(2-(2-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid90430 mg
    523-(4-(3-(3-hydroxypropoxy)propyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione90200 mg
    533-(3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propoxy)propyl methanesulfonate92100 mg
    544-((4,4-dimethoxybutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione97868 mg
    55ethyl 1-(3-cyanophenyl)piperidine-4-carboxylate851.68 g
    56ethyl 1-(4-cyanophenyl)piperidine-4-carboxylate9914.4 g
    57methyl 1-(7-hydroxyheptyl)-1H-indole-6-carboxylate87520 mg
    581-(7-hydroxyheptyl)-1H-indole-6-carboxylic acid96335 mg
    59methyl 1-(7-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)heptyl)-1H-indole-6-carboxylate95138 mg
    60tert-butyl 4-(2-((1s,3s)-3-hydroxycyclobutoxy)ethyl)piperazine-1-carboxylate85300 mg
    616-bromo-7-methoxy-2-methylquinazolin-4-ol88.460.0 mg
    62methyl 5-amino-2H-indazole-6-carboxylate9460.0 mg
    63tert-butyl 9-((methylsulfonyl)oxy)-3-azaspiro[5.5]undecane-3-carboxylate9060.0 mg
    64benzyl 4-(tosyloxy)piperidine-1-carboxylate9560.0 mg
    65N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.660.0 mg
    66tert-butyl 4-(3-(4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidin-1-yl)propyl)piperidine-1-carboxylate86.560.0 mg
    67tert-butyl 4-(3-(tosyloxy)propyl)piperidine-1-carboxylate9360.0 mg
    68perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-ethoxybenzoate9360.0 mg
    69(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethan-1-amine98100.0 mg
    70(R)-1-(2-fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine98100.0 mg
    71(R)-1-(3-nitro-5-(trifluoromethyl)phenyl)ethan-1-amine94100.0 mg
    722-amino-5-bromo-4-methoxybenzamide97100.0 mg
    73(R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethan-1-amine95100.0 mg
    742-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione98310 mg
    75perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoate92120 mg
    763-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid97115 mg
    77N-(2-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide9650 mg
    78tert-butyl ((1r,4r)-4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)cyclohexyl)carbamate80110 mg
    795-(4-(2,2-dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione93100 mg
    802-(2,6-dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione100170 mg
    81perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-morpholinobenzoate96110 mg
    82N-(2-((1r,4r)-4-((3-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3-azaspiro[5.5]undecan-9-yl)(ethyl)amino)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide98.320 mg
    835-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-chloro-1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide10075 mg
    84N-(2-(1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide100180 mg
    85tert-butyl 4-((1S,4s)-4-(4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)cyclohexane-1-carbonyl)piperazine-1-carboxylate91100 mg
    86N-(2-((1r,4r)-4-formylcyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide97.64105 mg
    87perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoate90.86115 mg
    88N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.47152 mg
    895-hydroxy-3-(2-(hydroxymethyl)-1H-indol-3-yl)isoindolin-1-one97.13116 mg
    90tert-butyl 4-(6-(difluoromethoxy)-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidine-1-carboxylate97.46106 mg
    91tert-butyl 9-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)-3-azaspiro[5.5]undecane-3-carboxylate97.85110 mg
    92tert-butyl 9-(4-(6-methoxy-5-nitro-2H-indazol-2-yl)cyclohexyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate96.8960 mg
    93N-(2-(1-(2-(3-azaspiro[5.5]undecan-9-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide98.12139 mg
    94N-(2-((1r,4r)-4-formylcyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide91.1581 mg
    95benzyl 2-(2-(tosyloxy)ethyl)-7-azaspiro[3.5]nonane-7-carboxylate91.63146 mg
    963-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indole-2-carbaldehyde9058 mg
    97tert-butyl 4-((3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indol-2-yl)methyl)piperazine-1-carboxylate80.83107 mg
    98N-(6-methoxy-2-((1r,4r)-4-((methylamino)methyl)cyclohexyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide95.91103 mg
    99tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate95237 mg
    1002A-196.051.3 g+300 mg
    101Pomalidomide-C6-CO2H99.3860 mg
    102Pomalidomide-C2-NH2 hydrochloride98.81244 mg
    103Pomalidomide-C3-NH2 hydrochloride99.6220 mg
    104Pomalidomide-C6-NH2 hydrochloride99.27185 mg
    105Pomalidomide-C7-NH2 hydrochloride99.36130 mg
    106Pomalidomide-C2-CO2H95.83380 mg
    107B-295.9460 mg
    108Pomalidomide-C5-CO2H95.19500 mg
    1092A-499.311.26 g
    110Pomalidomide-C9-CO2H98.8650 mg
    111B-997.19100 mg
    112B-896.06400 mg
    113B-1096.12160 mg
    1142A-296.61150 mg
    115Pomalidomide-PEG2-NH2 hydrochloride97.95400 mg
    116Pomalidomide-PEG1-NH2 hydrochloride96.34468 mg
    1172A-598.22168 mg
    118Pomalidomide-C8-NH2 hydrochloride99.18150 mg
    1195-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione97.1185 mg
    1204-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione98.6441 mg
    1215-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione99.950 mg
    1224-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione95.452 mg
    1235-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione991.547 g
    1242-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione903.5 g
    1252-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione90155 mg
    1261-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde90167 mg
    1275-(4-(hydroxymethyl)piperidin-1-yl)-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione99164 mg
    1282-(2,6-dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)azetidin-1-yl)isoindoline-1,3-dione98200 mg
    1292-(2,6-dioxopiperidin-3-yl)-4-(4-((4-hydroxypiperidin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione99134 mg
    1302-(2,6-dioxopiperidin-3-yl)-5-(3-hydroxyazetidin-1-yl)isoindoline-1,3-dione100101 mg
    1312-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoacetaldehyde8659 mg
    1325-(4-((4-(((R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pyrrolidin-1-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione10083 mg
    1332-(2,6-dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione96100 mg
    1342-(2,6-dioxopiperidin-3-yl)-5-(9-oxo-3-azaspiro[5.5]undecan-3-yl)isoindoline-1,3-dione96187 mg
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