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  The introduction, design and research of pharmaceutical intermediate productsSelection of commercial routesDevelopment and optimization of commercial processes, based on design of experiment (DoE) and quality by design (QbD)Research on unit operations and determination of key step-by-step process parametersResearch on the structure, source and control of impurities Determination of initial materials, based on GMP Timely procurement of laboratory-scale test results of pharmaceutical intermediates and pilot-scale testing so to provide a reliable technological basis for industrial productionStructural analysis and performance testing of pharmaceutical intermediates

Product List

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  Medicilon Protac intermediate product list

  Number	Compound Name	Purity	Inventory
  1	3-(2-aminoethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride	97.4	500 mg
  2	3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)propanamide hydrochloride	94.6	1.6 g
  3	1-amino-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12,15-pentaoxaoctadecan-18-amide hydrochloride	94.4	1.3 g
  4	t-Boc-N-amido-PEG5-acid	97	/
  5	t-Boc-N-amido-PEG1-acid	\	\
  6	Pomalidomide	99.8	\
  7	2-(2,6-dioxopiperidin-3-yl)-5-(2-(2-hydroxyethoxy)ethoxy)isoindoline-1,3-dione	90	9.5 g
  8	2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid	90	102 mg
  9	perfluorophenyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate	90	23 mg
  10	1-((1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)methyl)piperidine-4-carbaldehyde	90	100 mg
  11	2-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	90	200 mg
  12	1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)piperidine-4-carbaldehyde	90	100 mg
  13	2-(2,6-dioxopiperidin-3-yl)-4-(4-(3-hydroxypropyl)piperidin-1-yl)isoindoline-1,3-dione	96.4	102.08 mg
  14	2-(2,6-dioxopiperidin-3-yl)-4-(3-(hydroxymethyl)pyrrolidin-1-yl)isoindoline-1,3-dione	94.8	101.91 mg
  15	1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carboxylic acid	97.7	104.5 mg
  16	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione hydrochloride	98.3	103 mg
  17	2-(2,6-dioxopiperidin-3-yl)-5-(piperidin-4-yloxy)isoindoline-1,3-dione hydrochloride	92.46	101 mg
  18	2-(2,6-dioxopiperidin-3-yl)-5-[4-(hydroxymethyl)-3-methylpiperidin-1-yl]isoindole-1,3-dione	95.1	103 mg
  19	2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione	97.8	102 mg
  20	QL12003-700-1	95.7	26 mg
  21	QL12003-707-2	93.9	28 mg
  22	QL12003-707-1	99.7	20 mg
  23	QL12003-667-3	62	20 mg
  24	QL12003-667-1	99.4	27 mg
  25	QL12003-650-1	63.2	28 mg
  26	inter14-10		90 mg
  27	QLS12010-1058-4		20mg
  28	QLS12003-697-3		27.61mg
  29	QL-MDC1001-3		2.342 g
  30	QL-MDC1001-4		1.680 g
  31	QLS12003-504-5		2.02 g
  32	QLS12003-605-1	96.3	240 mg
  33	QLS12003-605-2	99.2	65 mg
  34	QLS12003-605-3	88.7	60 mg
  35	QLS12003- inter14	86.7	50 mg
  36	QLS12003- inter1-7		65 mg
  37	QLS12003- 563-7		30 mg
  38	QLS12003-693-2		85 mg
  39	QLS12003-696-2	93.7	54 mg
  40	QLS12003-609-2	82	110 mg
  41	tert-butyl 4-(2-((1s,3s)-3-(benzyloxy)cyclobutoxy)ethyl)piperazine-1-carboxylate	95	2.05 g
  42	tert-butyl (3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propyl)(methyl)carbamate	98	213 mg
  43	tert-butyl 3-(prop-2-yn-1-yloxy)propanoate	95	0.66 g
  44	tert-butyl 9-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)nonanoate	95	1.33 g
  45	tert-butyl 4-(2-((1s,3s)-3-((methylsulfonyl)oxy)cyclobutoxy)ethyl)piperazine-1-carboxylate	95	167 mg
  46	tert-butyl (2-(3-hydroxypropoxy)ethyl)carbamate	95	1.45 g
  47	5-(4-((1,4-dioxaspiro[4.5]decan-8-yl)methyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-6-fluoroisoindoline-1,3-dione	99	2.83 g
  48	2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(4-((4-oxocyclohexyl)methyl)piperazin-1-yl)isoindoline-1,3-dione	95	740 mg
  49	3-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)propanoic acid	95	430 mg
  50	tert-butyl 3-(2-(2-(2-(4-(4-(hydroxymethyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoate	95	760 mg
  51	3-(2-(2-(2-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)propanoic acid	90	430 mg
  52	3-(4-(3-(3-hydroxypropoxy)propyl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidine-2,6-dione	90	200 mg
  53	3-(3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)propoxy)propyl methanesulfonate	92	100 mg
  54	4-((4,4-dimethoxybutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	97	868 mg
  55	ethyl 1-(3-cyanophenyl)piperidine-4-carboxylate	85	1.68 g
  56	ethyl 1-(4-cyanophenyl)piperidine-4-carboxylate	99	14.4 g
  57	methyl 1-(7-hydroxyheptyl)-1H-indole-6-carboxylate	87	520 mg
  58	1-(7-hydroxyheptyl)-1H-indole-6-carboxylic acid	96	335 mg
  59	methyl 1-(7-(4-(2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxoisoindolin-4-yl)piperidin-1-yl)heptyl)-1H-indole-6-carboxylate	95	138 mg
  60	tert-butyl 4-(2-((1s,3s)-3-hydroxycyclobutoxy)ethyl)piperazine-1-carboxylate	85	300 mg
  61	6-bromo-7-methoxy-2-methylquinazolin-4-ol	88.4	60.0 mg
  62	methyl 5-amino-2H-indazole-6-carboxylate	94	60.0 mg
  63	tert-butyl 9-((methylsulfonyl)oxy)-3-azaspiro[5.5]undecane-3-carboxylate	90	60.0 mg
  64	benzyl 4-(tosyloxy)piperidine-1-carboxylate	95	60.0 mg
  65	N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.6	60.0 mg
  66	tert-butyl 4-(3-(4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidin-1-yl)propyl)piperidine-1-carboxylate	86.5	60.0 mg
  67	tert-butyl 4-(3-(tosyloxy)propyl)piperidine-1-carboxylate	93	60.0 mg
  68	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-ethoxybenzoate	93	60.0 mg
  69	(R)-1-(3-bromo-5-(trifluoromethyl)phenyl)ethan-1-amine	98	100.0 mg
  70	(R)-1-(2-fluoro-3-(trifluoromethyl)phenyl)ethan-1-amine	98	100.0 mg
  71	(R)-1-(3-nitro-5-(trifluoromethyl)phenyl)ethan-1-amine	94	100.0 mg
  72	2-amino-5-bromo-4-methoxybenzamide	97	100.0 mg
  73	(R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethan-1-amine	95	100.0 mg
  74	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione	98	310 mg
  75	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoate	92	120 mg
  76	3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-methoxybenzoic acid	97	115 mg
  77	N-(2-((1r,4r)-4-(2-hydroxyethyl)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	96	50 mg
  78	tert-butyl ((1r,4r)-4-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)cyclohexyl)carbamate	80	110 mg
  79	5-(4-(2,2-dimethoxyethyl)piperazin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	93	100 mg
  80	2-(2,6-dioxopiperidin-3-yl)-5-(4-(2-hydroxyethyl)piperidin-1-yl)isoindoline-1,3-dione	100	170 mg
  81	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-4-morpholinobenzoate	96	110 mg
  82	N-(2-((1r,4r)-4-((3-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3-azaspiro[5.5]undecan-9-yl)(ethyl)amino)cyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	98.3	20 mg
  83	5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-chloro-1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide	100	75 mg
  84	N-(2-(1-(2-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidin-4-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	100	180 mg
  85	tert-butyl 4-((1S,4s)-4-(4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)cyclohexane-1-carbonyl)piperazine-1-carboxylate	91	100 mg
  86	N-(2-((1r,4r)-4-formylcyclohexyl)-6-methoxy-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	97.64	105 mg
  87	perfluorophenyl 3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoate	90.86	115 mg
  88	N-(6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.47	152 mg
  89	5-hydroxy-3-(2-(hydroxymethyl)-1H-indol-3-yl)isoindolin-1-one	97.13	116 mg
  90	tert-butyl 4-(6-(difluoromethoxy)-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)piperidine-1-carboxylate	97.46	106 mg
  91	tert-butyl 9-(6-methoxy-5-(6-(trifluoromethyl)picolinamido)-2H-indazol-2-yl)-3-azaspiro[5.5]undecane-3-carboxylate	97.85	110 mg
  92	tert-butyl 9-(4-(6-methoxy-5-nitro-2H-indazol-2-yl)cyclohexyl)-3,9-diazaspiro[5.5]undecane-3-carboxylate	96.89	60 mg
  93	N-(2-(1-(2-(3-azaspiro[5.5]undecan-9-yl)ethyl)piperidin-4-yl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	98.12	139 mg
  94	N-(2-((1r,4r)-4-formylcyclohexyl)-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	91.15	81 mg
  95	benzyl 2-(2-(tosyloxy)ethyl)-7-azaspiro[3.5]nonane-7-carboxylate	91.63	146 mg
  96	3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indole-2-carbaldehyde	90	58 mg
  97	tert-butyl 4-((3-(6-hydroxy-3-oxoisoindolin-1-yl)-1H-indol-2-yl)methyl)piperazine-1-carboxylate	80.83	107 mg
  98	N-(6-methoxy-2-((1r,4r)-4-((methylamino)methyl)cyclohexyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	95.91	103 mg
  99	tert-butyl (2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)ethoxy)ethoxy)ethyl)carbamate	95	237 mg
  100	2A-1	96.05	1.3 g+300 mg
  101	Pomalidomide-C6-CO2H	99.38	60 mg
  102	Pomalidomide-C2-NH2 hydrochloride	98.81	244 mg
  103	Pomalidomide-C3-NH2 hydrochloride	99.6	220 mg
  104	Pomalidomide-C6-NH2 hydrochloride	99.27	185 mg
  105	Pomalidomide-C7-NH2 hydrochloride	99.36	130 mg
  106	Pomalidomide-C2-CO2H	95.83	380 mg
  107	B-2	95.9	460 mg
  108	Pomalidomide-C5-CO2H	95.19	500 mg
  109	2A-4	99.31	1.26 g
  110	Pomalidomide-C9-CO2H	98.86	50 mg
  111	B-9	97.19	100 mg
  112	B-8	96.06	400 mg
  113	B-10	96.12	160 mg
  114	2A-2	96.61	150 mg
  115	Pomalidomide-PEG2-NH2 hydrochloride	97.95	400 mg
  116	Pomalidomide-PEG1-NH2 hydrochloride	96.34	468 mg
  117	2A-5	98.22	168 mg
  118	Pomalidomide-C8-NH2 hydrochloride	99.18	150 mg
  119	5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	97.1	185 mg
  120	4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	98.6	441 mg
  121	5-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99.9	50 mg
  122	4-fluoro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	95.4	52 mg
  123	5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99	1.547 g
  124	2-(2,6-dioxopiperidin-3-yl)-4-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	90	3.5 g
  125	2-(2,6-dioxopiperidin-3-yl)-5-(piperazin-1-yl)isoindoline-1,3-dione	90	155 mg
  126	1-(2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde	90	167 mg
  127	5-(4-(hydroxymethyl)piperidin-1-yl)-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	99	164 mg
  128	2-(2,6-dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)azetidin-1-yl)isoindoline-1,3-dione	98	200 mg
  129	2-(2,6-dioxopiperidin-3-yl)-4-(4-((4-hydroxypiperidin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione	99	134 mg
  130	2-(2,6-dioxopiperidin-3-yl)-5-(3-hydroxyazetidin-1-yl)isoindoline-1,3-dione	100	101 mg
  131	2-(4-((4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazin-1-yl)methyl)piperidin-1-yl)-2-oxoacetaldehyde	86	59 mg
  132	5-(4-((4-(((R)-3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)pyrrolidin-1-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione	100	83 mg
  133	2-(2,6-dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	96	100 mg
  134	2-(2,6-dioxopiperidin-3-yl)-5-(9-oxo-3-azaspiro[5.5]undecan-3-yl)isoindoline-1,3-dione	96	187 mg

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