Medicinal Chemistry

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Service

• Medicilon’s medicinal chemistry services include:
  Feasibility assessment of new drug targetsHigh-throughput screening and discovery of active compounds based on  structural designSAR-based compound synthesis and SAR-based optimizationEstablishment of specific compound libraries (establishment of micromolecule compound library)Rapid synthesis of PROTAC molecules and ADC payloads, as well as lipids, glycolipids, and phospholipidsScreening of new hit compounds (from active compounds to discovery of lead compounds) Synthesis, discovery, and optimization of hit compoundsResearch on SARComputer-aided drug design (CADD) Processes from optimization of lead compounds to determination of preclinical drug candidatesPatent preparation and applicationELN system recordsMulti-parameter lead optimization for desired target molecule profiles (synthesis, discovery, and structural optimization of lead compounds)

Features

• An efficient team driven by deadlines
  The chemistry department of Medicilon has 1500 employees:About 40% have a PhD or Master's degreeMore than 10% of the employees have a foreign education and/or work experienceAverage working experience ofjunior research staff (researchers) : 3-5 yearsmiddle-level researchers (group leader level): 8-10 yearssenior level (director level and above): 15-20 years            Efficient team performance parameters: Fee for service (FFS) on-time delivery rate > 80%; Chemical reaction success rate > 85%;One compound delivered per full-time equivalent (FTE) each week;The number of reactions completed by each scientific researcher each week > 12.
• Advanced equipment
  Supported by high-throughput chromatography and mass spectrometry and advanced processing software, Medicilon sets high standards for our compound screening and analysis, optimization of lead compounds, analysis of chemical and physical properties of compounds, and other drug R&D processes. Our 10,000 m² laboratory in Shanghai Nanhui Industrial Park is equipped with a comprehensive library of instruments and is managed via a modern business model. We  guarantee the quality and efficiency of any project we undertake.
• Featured Platform-PROTACs Drug
  Our Medicinal Chemistry Department has established a PROTAC drug discovery platform that contains popular target protein ligands. We have also established libraries for high-affinity targeting protein small molecule (TPSM) and small molecular fragments, libraries for high-affinity ubiquitin ligase small molecule (E3SM) and small molecular fragments, and linker systems that include diversified bi-functional linkers (BF-Linker). Those compound libraries help to quickly and efficiently synthesize a large number of high-activity PROTAC  bi-specific small molecules, thus greatly accelerating the process of R&D.
• Featured Platform - Nucleic Acid Drugs
  Medicilon's nucleic acid drug discovery platform is an integrated and comprehensive platform for drug discovery, manufacturing and preclinical research. Medicilon has built an siRNA library with not only a rich inventory of monomers, but also a large library of monomer synthesis blocks, which can rapidly complete the synthesis of various types of modified monomers. Medicilon has a professional small nucleic acid drug development team, and several siRNA drug FTE projects have been completed and are in progress.
• Featured Platform-ADC Drugs
  Each ADC R&D project provides its own challenges due to the varieties in the assembly of ADC molecules. With this in mind, Medicilon promises careful planning, meticulous execution and accurate results achievable because we have many years of practical experience and undertake effective communication with our clients.

Service Cases

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