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Preclinical Research

Endocrine & Metabolic Disease Models

In the field of metabolic diseases, we are proud of our portfolio of stable and effective animal models, especially those for Non-alcoholic Fatty Liver Disease (NAFLD). Though popular recently, they still lack effective drug treatment.
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DiseasesModelsAnimals
Obesity and diabetesStreptozotocin-inducedRats/mice
SpontaneousMice (db/db, ob/ob)
SpontaneousZDF rats
High-fat and high-sugar diet-inducedMice
HyperuricemiaPotassium oxonate-inducedRats/mice
UA-inducedMice
Hypoxanthine-inducedMice
Adenine- and ethambutol-inducedRats
Liver fibrosisBile duct ligationRats
TAA-inducedRats
Composite factor method-inducedRats
ConA-inducedMice
Porcine serum-inducedRats
Lipid abnormalityHigh fat/cholesterol/fructose diet-inducedHamster
Hereditary atherosclerosis (APOE mice + high-fat diet)APOE mice
Non-alcoholic fatty liver (NAFLD, NAFL, NASH)Hereditary atherosclerosis (APOE mice)APOE mice
Non-alcoholic fatty liverRats
High-fat diet (HFD)Rats/mice, hamsters
Methionine- and choline-deficient diet (MCD)Mice
Composite factor-inducedRats
ThrombusArteriovenous bypass thrombosisRats/mice
Carrageenan-induced tail vein thrombosisMice
Deep vein thrombosisRats
Carotid artery thrombosisRats/mice
  • Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain and systemic tissues caused by hyperlipidemia, blood viscosity, atherosclerosis, and hypertension. Medicilon has established rat and mouse MCAO model evaluation system with stable lesions, high success rate, high survival rate and reliable and effective evaluation of dose-effect/time-effect relationship. We can provide efficacy evaluation of transient cerebral ischemia and permanent cerebral ischemia and complete the investigation of various pharmacodynamic core indicators according to STAIR technical guidelines. The model rodents could be customized with special diseases and complete activity evaluations according to customer requirements.

    Disease Name

    ICD 10

    Model

    Intracerebral hemorrhage

    I60-I62

    Intracranial autologous blood injection, subarachnoid hemorrhage

    Cerebral infarction

    I63

    Ischemic stroke model

    Stroke

    I64

    Cerebral Embolism

    I65

    Cerebral Embolism

    I66

    Other

    I67-I69

    Other

FAQ
  • What is the Difference Between NAFL and NASH?

    NAFL:

    It is completely reversible and can be completely reversed through a healthy lifestyle such as diet and exercise controlling diet, exercise and other healthy lifestyles. Drug therapy is mainly to improve lipid metabolism.

    NASH:

    It is a progressive form of nonalcoholic fatty liver disease, a metabolically stressful metabolic stress liver injury closely associated with insulin resistance and genetic predisposition, can progress to cirrhosis and hepatocellular carcinoma. It was also significantly associated with an increased risk of cardiovascular disease.

    The etiology of NASH is complex, and the exact pathogenesis is unknown. There is no specific treatment or drug therapy for Nash.

    NASH treatment drugs with different targets have become one of the current research and development hotspots, which target the different pathogenesis of NASH, such as liver metabolism, inflammation, oxidative stress, fibrosis, etc.

Relevant laboratories
  • LC/MS
  • centrifuge
  • Pathological observation
  • pathological section
  • frozen slice
  • high-speed centrifuge
  • SPE
  • Liquid analysis laboratory
  • Pharmaceutical laboratory
  • Inspection equipment
  • isotope
  • Immunoassay Platform
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