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Preclinical research
Neural System Disease Models
Our Pharmacodynamics Department is proud of its multiple nervous system models based on anti-depressants, anti-Alzheimer's drugs, sedative-hypnotic and anti-anxiety drugs, analgesics, anti-convulsants, anti-Parkinson's drugs, and anti-schizophrenia drugs. Those models can effectively evaluate Type-1 innovative drugs at the molecular and cellular level, as well as ex vivo, and in vivo. The Department’s advanced Cognition Wall Discrimination learning ensures uninterrupted tracking to determine changes in memory function in double transgenic mice during tearly-stage Alzheimer's disease, and eliminates the disadvantages of the Morris water maze (MWM) in stress interference and short-time tests.
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DiseasesNervous System Disease ModelsAnimals
Anti-depressantInhibition of 5-HT, NA and DA brain synaptosome uptake (sample selection and IC 50 Determination)Rats
Forced swimming test (rats/mice, Noduls, video analysis)Rats/mice
Tail suspension test (mice, Noduls, video analysis)Mice
5-HTP-induced head twitch potentiationMice
Reserpine-induced ptosisMice
Yohimbine toxicity enhancement testMice
High-dose apomorphine antagonismMice
Chronic mild unpredictable stimulation (CUMS) in ratsRats
New environment eating inhibition testRats/mice
MAO-A, MAO-B activity testMice
Protective effects on hippocampal neurons of newborn rats
(glutamate injury, hydrogen peroxide injury, glucose and hypoxia injury, and dexamethasone injury, among others)
Newborn rats
Effect on synthesis and secretion of BDNF in SH-SY5Y cellsSH-SY5Y cells
Anticonvulsant testYohimbine toxicity enhancement testMice
Pentylenetetrazole-induced seizureMice
Dicentime-induced seizureMice
Picrotoxin-induced seizureMice
Sedative-hypnotic and anti-anxiety testsSynergistic effect with pentobarbital drugsMice
Effect on subthreshold hypnotic dose of barbitalMice
Re-sleep testMice
Open field test (rats/mice, camera monitoring and software processing for whole process)Rats/mice
Elevated plus maze testRats
Shuttle box test (full camera monitoring and software processing)Rats
Pain (with Von Frey hairs test)Hot plate testRats/mice
Tail-flick testRats/mice
Heat radiation testRats/mice
Tenderness testRats/mice
Von Frey hairsRats/mice
Acetic acid-induced writhing testMice
Formalin-induced testRats/mice
CFA-induced painRats/mice
Carrageenan-induced painRats/mice
LPS-induced painRats/mice
Selective spinal nerve ligation (L5/L6)Rats/mice
Sciatic nerve injuries (SNI)Rats/mice
Pain induced by diabetes, incision, and cancerRats/mice
Anti-dementia testsAcquired memory impairment (6-channel video analysis of the step-down test)Mice
Memory consolidation impairment (6-channel video analysis of the step-down test)Mice
Memory retrieval impairment (6-channel video analysis of the step-down test)Mice
Light-dark transition testing (4-channel video analysis)Mice
Acquired memory impairment (Morris water maze video analysis)Rats
Acetylcholinesterase ActivityMice
D-galactoseMice
New object recognition testingRats
APP/PS1 (Morris water maze, Cognition Wall)Transgenic mice
In vitro testingCell level, molecular biology
Anti-schizophreniaMK801-induced schizophrenia with positive symptomsMice
MK801-induced schizophrenia with negative symptomsMice
Ketamine-induced schizophrenia with negative symptomsMice
CatalepsyRats
Lower lip retractionRats
Phencyclidine-induced activity enhancementRats
Relevant laboratories
Relevant articles