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Preclinical Research

PDX Models

Patient-Derived Tumor Xenograft Model (PDX): This model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy. Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.
medicilon icon-diamond.pngModel Type
Patient-Derived Tumor Xenograft (PDX) model retains the characteristics of patients’ tumor tissues and features more clinical relevance. Combined with humanized mice, the model can promise ideal evaluation of tumor immuno-oncology. Now, we have the following models:
                        Cancer Type                        Cell Lines
                        Colon cancer                      PDXM-008C, PDXM-016C, PDXM-020C, PDXM-021C, PDXM-057C, PDXM-060C, PDXM-075C, PDXM-076C, PDXM-087C, PDXM-104C, PDXM-095C, PDXM-084C, PDXM-072C, PDXM-069C, PDXM-057C, PDXM-015C, PDXM-002C,
Lung cancer                        PDXM-054Lu, PDXM-050Lu, PDXM-047Lu, PDXM-053Lu, PDXM-028Lu,
Gastric cancerPDXM-092Ga, PDXM-091Ga,
Breast cancerPDXM-201B
Liver cancerPDXM-211Li
Pancreas cancerPDXM-221Pa, PDXM-222Pa
  • PDX Models
    PDX models(Neuro-Oncology).png
    SNI:Neuro-Oncology 2015, Vol 6, Suppl I - A supplement to Surgical Neurology International
Our research on PDX model includes molecular level genotyping and pharmacological efficacy evaluation service of orthotopic model, promising great prediction for clinical efficacy research.
  • PDX Model (Growth Curve)
    PDX Model (Growth Curve).png
  • PDX Model (MED-PDX-001C H&E (10X))
    PDX model.png
Relevant laboratories
  • Frozen section
  • Pathological observation
  • Pharmacodynamics Laboratory
  • flow cytometer
  • animal breeding room
  • operating room
  • RAD
  • caliper
  • FCM
  • IVIS-Lumina-III-In-Vivo-Imaging-System
  • BD-LSRFortessa
Relevant articles