PDX Models

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Model Type

FAQ

• What is a PDX Mouse Model?

  The PDX model, as known as the patient derived tumor xenograft (PDX) model, is a model constructed by directly transplanting tumor tissue from a tumor patient into a severely immunodeficient mouse and making the tumor tissue grow in the mouse.

• Advantages of the PDX Model

  There is no in vitro culture process to "screen" tumors

  Maintain the original characteristics and heterogeneity of the tumor

  Maintain the consistency at the biology level of tumor molecular

  Preserve the original non-tumor stroma and microenvironment

  Patient-derived tumors can be studied in a variety of conditions

• Application of PDX Models

  • New drug development
  In particular, patient screening and predictive biomarker study in clinical trials of tumor immune-targeted drugs. The efficacy evaluation results of PDX and clinical similarity reached 87% (CDX only 5%).

  • Personalized Medicine:
  PDX model can be used to conduct PD evaluation experiments for tumor patients, which can be used for drug reference for clinical tumor patients.

  • Molecular Marker development (Biomarker)
  Drug reaction -- Molecular biological mechanisms

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