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PDX Models

PDX Models

The Patient-Derived Tumor Xenograft (PDX): model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy . Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.
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medicilon icon-diamond.pngModel Type
Patient-Derived Tumor Xenograft (PDX) models retain the characteristics of patients’ tumor tissues and demonstrate more clinical relevance than CDX models. Combined with humanized mice, the model can promise optimum evaluation of tumor immuno-oncology therapeutics. We have the following models with more under development:
                        Cancer Type                        Cell Lines
                        Colon cancer                      PDXM-008C, PDXM-016C, PDXM-020C, PDXM-021C, PDXM-057C, PDXM-060C, PDXM-075C, PDXM-076C, PDXM-087C, PDXM-104C, PDXM-095C, PDXM-084C, PDXM-072C, PDXM-069C, PDXM-057C, PDXM-015C, PDXM-002C,
Lung cancer                        PDXM-054Lu, PDXM-050Lu, PDXM-047Lu, PDXM-053Lu, PDXM-028Lu,
Gastric cancerPDXM-092Ga, PDXM-091Ga,
Breast cancerPDXM-201B, PDXM-202B, PDX-203B
Liver cancerPDXM-211Li, PDXM-212Li
Pancreas cancerPDXM-221Pa, PDXM-222Pa
Bladder CancerPDXM-231U, PDXM-232U
LymphomaPDXM-241Ly, PDXM-242Ly
  • PDX Models
    PDX Models.png
    SNI:Neuro-Oncology 2015, Vol 6, Suppl I - A supplement to Surgical Neurology International
Our research on PDX model includes molecular level genotyping and pharmacological efficacy evaluation service of orthotopic model, promising great prediction for clinical efficacy research.
  • PDX Model (Growth Curve)
    PDX Model (Growth Curve).png
  • PDX Model (MED-PDX-001C H&E (10X))
    PDX Model (MED-PDX-001C H&E (10X)).png
FAQ
  • What is a PDX Mouse Model?

    The PDX model, as known as the patient derived tumor xenograft (PDX) model, is a model constructed by directly transplanting tumor tissue from a tumor patient into a severely immunodeficient mouse and making the tumor tissue grow in the mouse.

  • Advantages of the PDX Model

    There is no in vitro culture process to "screen" tumors

    Maintain the original characteristics and heterogeneity of the tumor

    Maintain the consistency at the biology level of tumor molecular

    Preserve the original non-tumor stroma and microenvironment

    Patient-derived tumors can be studied in a variety of conditions

  • Application of PDX Models

    New drug development
    In particular, patient screening and predictive biomarker study in clinical trials of tumor immune-targeted drugs. The efficacy evaluation results of PDX and clinical similarity reached 87% (CDX only 5%).

    Personalized Medicine:
    PDX model can be used to conduct PD evaluation experiments for tumor patients, which can be used for drug reference for clinical tumor patients.

    Molecular Marker development (Biomarker)
    Drug reaction -- Molecular biological mechanisms

Relevant laboratories
  • Frozen section
  • Pathological observation
  • Pharmacodynamics Laboratory
  • flow cytometer
  • animal breeding room
  • operating room
  • RAD
  • caliper
  • FCM
  • IVIS-Lumina-III-In-Vivo-Imaging-System
  • BD-LSRFortessa
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