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Pharmacology & Pharmacodynamics

Pharmacology & Pharmacodynamics

Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model library based on verification, precise and efficient drug efficacy testing. The test subjects we provide include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.

  • Support research on the efficacy of combined radiotherapy and chemotherapy treatmentsSupport research on the efficacy of combination of small and large molecule drugsSupport research on the efficacy of the evaluation of various non-oncology drugs
  • Tumor animal models
    186 Xenograft Models30 Humanized Models30 Syngeneic Models50 Orthotopic Models100 PDX Models

    Data as of 2024.03.27

  • Non-tumor animals models
    64 CNS Diseases Models32 Inflammation & Immune System25 Cardiovascular Models18 Digestive System Disease Model10 Ocular Disease Model39 Endocrine & Metabolic Disease Models52 Other Disease Models

    Data as of 2024.03.27

Medicilon diamond icon.pngFeature Platform
  • Nucleic Acid Drug Pharmacology Evaluation In vivo Pharmacodynamic Studies of Cellular Immunotherapies In Vivo Efficacy Tests of PROTAC-POI Pharmacology Evaluation of ADC
Tumor Models

Medicilon boasts about 400 tumor evaluation models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology. We have completed model establishment and efficacy evaluation of immuno-therapies such as CAR-T, TCR-T, CAR-NK, oncolytic virus, antibody (monoclonal, double, polyclonal), siRNA and AAV.

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PDX Models

The Patient-Derived Tumor Xenograft (PDX): model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy . Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.

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CDX Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models are created by implanting cancer cell lines into immunodeficient mice and have contributedsignificantly to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice.

After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to long-term cell passage in vitro, cells have the characteristics of high homology and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.

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GEM Models
Genetically engineered mouse (GEM) models are widely used and have proved to be a powerful tool to improve drug discovery processes. Using transgenic technology, extra DNA that encodes the gene of interest can be integrated into the mouse genome; using knockout or knock-in technology, specific regions of the mouse genome can be selectively deleted or modified.
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Humanized Mouse Models
Humanized mice can simulate key biological characteristics of human beings, and they are very useful for establishing preclinical pharmacodynamic evaluation models. They can provide suitable pharmacodynamic models for testing protein-derived drugs such as antibodies or antibody-drug conjugates (ADCs).
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Syngeneic Mouse Models
Syngeneic mouse models test the ability of animals to fight cancer with an intact immune system and is used to test the therapeutic effects of immunotherapy. We can provide various syngeneic models to test the effectiveness of drugs according to our clients' requirements. Typical orthotopic disease models include breast cancer, lung cancer, colon cancer, kidney cancer and diffuse large B-cell lymphoma (DLBCL), utilising mice, rats and hamsters as test subjects.
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Orthotopic Cancer Models
The orthotopic cancer model assesses the interaction between tumor cells and drugs in their natural organ/microenvironment and monitors tumor growth in situ. We have a variety of mature orthotopic transplantation models available, including brain, liver, lung, tibial bone marrow cavity, and intravesical orthotopic transplantation models.
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