Pharmacology & Pharmacodynamics Study

Patient-Derived Tumor Xenograft Model (PDX): This model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy. Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.

We can provide various effective transgenic models to test the effectiveness of drugs according to our clients’ requirements. Typical orthotopic diseases include hPD-1 and hCTLA4, with mice, rats and hamsters as test subjects.

Humanized mice can easily simulate the biological characteristics of human beings. They are very important for the establishment of preclinical pharmacodynamic evaluation models, and can provide suitable pharmacodynamic models for testing biotechnology drugs such as antibodies or antibody drug conjugates (ADCs).

The syngeneic mouse model tests the ability of model animals to fight cancer with their perfect immune system, as well as the therapeutic effects of immunotherapy. We can provide various syngeneic models to test the effectiveness of drugs according to our clients’ requirements. Typical orthotopic diseases include breast cancer, lung cancer, colon cancer, kidney cancer, diffuse large B-cell lymphoma (DLBCL), etc., with mice, rats and hamsters as test subjects.

The orthotopic cancer model considers the interaction between tumor cells and their surrounding interstitial organ microenvironment and monitors tumor growth in drug efficacy evaluation. We can break down the barriers of experiment and technology with mature orthotopic transplantation models, including brain orthotopic transplantation, liver orthotopic transplantation, lung orthotopic transplantation, tibial bone marrow cavity orthotopic transplantation, and intravesical orthotopic transplantation.