Medicilon Logo
|
search icon search icon language icon contact icon menu icon
Medicilon Logo
|
search icon close search icon language icon contact icon menu icon
CN
Contact Us
Close Button
Message
Back To Top
Online Message×
Click switch
Close Button
Pharmacology & Pharmacodynamics

Pharmacology & Pharmacodynamics

Keeping pace with industrial development and market demand, Medicilon's Pharmacology and Pharmacodynamics Department boasts years of experience, and has established a complete animal model library based on verifications and practices for precise and efficient drug efficacy testing. The test subjects include non-human primates, dogs, rats/mice, rabbits, guinea pigs, and miniature pigs.

Tumor Models

Medicilon boasts nearly 300 tumor evaluation models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology. We have completed model establishment and efficacy evaluation of immuno-therapies such as CAR-T, TCR-T, CAR-NK, oncolytic virus, antibody (monoclonal antibody, double antibody, polyclonal antibody, etc.), siRNA, AAV.

Learn more
Cardiovascular Model
Medicilon has established many cardiovascular models, which contain Dyslipidemia model, Thrombosis & anemia model, MCAO model, and Anemia model for pharmacodynamics research.
Learn more
Ocular Diseases Models
Medicilon has established ocular diseases models, which contain Conjunctival tissue proliferation and NV model, Diabetic retinopathy (DR) model, Choroidal neovascularization (CNV) and subretinal fibrosis model, Corneal neovascularization (Corneal NV) model, Retinal neovascularization model, Acute ocular inflammation models, and dry eye models.
Learn more
CDX Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models created by implanting cancer cell lines into immunodeficient mice have contributed largely to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice.

After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to the long-term cell passage in vitro, they have the characteristics of high homology, easy construction, and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.

Learn more
PDX Models
Patient-Derived Tumor Xenograft Model (PDX): This model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy. Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.
Learn more
GEM Models
Genetically engineered mouse (GEM) models are widely used and have proved to be a powerful tool in drug discovery processes. GEM models of human disease could improve drug development. GEM models of human disease could improve drug development. Using transgenic technology, extra DNA that encodes the gene of interest can be integrated into the mouse genome; using knockout or knock-in technology, specific regions of the mouse genome can be selectively deleted or modified.
Learn more