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Pharmacology & Pharmacodynamics

Pharmacology & Pharmacodynamics

Keeping pace with industrial development and market demand, Medicilon's experienced Pharmacology and Pharmacodynamics Department has established a complete animal model library based on verification, precise and efficient drug efficacy testing. The test subjects we provide include non-human primates, dogs, rats, mice, rabbits, guinea pigs, and miniature pigs.

  • Support research on the efficacy of combined radiotherapy and chemotherapy treatmentsSupport research on the efficacy of combination of small and large molecule drugsSupport research on the efficacy of the evaluation of various non-oncology drugs
  • Tumor animal models
    ~150 Xenograft Models~30 Humanized Models~30 Syngeneic Models~35 Orthotopic Models~50 PDX Models
  • Non-tumor animals models
    ~40 CNS Diseases Models~10 Inflammation & Immune System~20 Cardiovascular & metabolic~10 Digestive System Disease Model~10 Ocular Disease Model~5 Other disease models
Medicilon diamond icon.pngFeature Platform
  • Nucleic Acid Drug Pharmacology Evaluation In vivo Pharmacodynamic Studies of Cellular Immunotherapies In Vivo Efficacy Tests of PROTAC-POI Pharmacology Evaluation of ADC
Neural System Disease Models
Our Pharmacodynamics Department can deliver multiple nervous system models based on anti-depressants, anti-Alzheimer's drugs, sedative-hypnotic and anti-anxiety drugs, analgesics, anti-convulsants, anti-Parkinson's drugs, and anti-schizophrenia drugs. Those models can effectively evaluate innovative drugs at the molecular and cellular level, as well as ex vivo, and in vivo. The Department's advanced Cognition Wall Discrimination learning ensures uninterrupted tracking to determine changes in memory function in double transgenic mice during early-stage Alzheimer's disease and eliminates the disadvantages of the Morris water maze (MWM) in stress interference and short-time tests.
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Other Disease Models
Medicilon offers various effective animal models, including customized ones, based on clients' needs. Typical models include those for full-thickness skin trauma, pressure ulcers, and spontaneous hypertension with rats/mice and SHR as subjects. Further, Medicilon also offers non-human primates for pharmacology studies, such as using monkeys for cell therapy for Type-1 diabetes; and mini-pig for analgesic effect evaluation.
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Ocular Diseases Models
Medicilon has established ocular diseases models, including the Conjunctival tissue proliferation and NV, Diabetic retinopathy (DR), Choroidal neovascularization (CNV) and subretinal fibrosis, Corneal neovascularization (Corneal NV), Retinal neovascularization, Acute ocular inflammation, and dry eye models.
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Cardiovascular Model
Medicilon has established many cardiovascular models including the Dyslipidemia, Thrombosis & anemia, MCAO, and Anemia models for pharmacodynamics research.
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