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Radiolabel ADME

Radiolabel ADME

Medicilon has an advanced laboratory with isotope pharmacokinetic analysis capabilities for innovative drugs, and an integrated service platform integrating radiosynthesis, radiolabelling, testing, and analysis, providing comprehensive technical support for the research and development of new antibodies and vaccines.
  • Medicilon provides synthesis services of standard products and isotope internal standards, has the capability of isotope pharmacokinetic analysis of innovative drugs, and has served many pharmaceutical companies in the development and IND of new drugs. We have an advanced laboratory with isotope pharmacokinetic analysis capabilities for innovative drugs, and an integrated service platform integrating radiosynthesis, radiolabelling, testing, and analysis, providing comprehensive technical support for the research and development of new antibodies and vaccines.
Radio-labelled Sciences Platform Introduction & Capabilities
  • Comprehensive in vivo and in vitro Capabilities (small molecules and biologics)In vivo PK, Distribution, Mass Balance, Metabolic Profiling, and MetID with Radiolabelled CompoundsIn vitro RadiobiologyIntegrated IND Package for NMPA and FDAAnimal Housing Capacity (Radioactivity permit at Zhangjiang site)Radioanalysis Capacity (Zhangjiang site)
In vivo and in vitro Capabilities (small molecules and biologics)
  • In vitro
    Receptor binding assayTransporter uptake assayThymidine incorporation assayKinase assayHistone methylation assayHistone acetylation assay
  • In vivo
    Species:Rat, MouseIn-vivo PKTissue distributionMass balance with excretionIn-vivo metabolite identification and quantitation (Cold)In-vivo metabolite identification and quantitation (Hot)
Case
  • Case study 1: Radio-ligand binding/competition assay

    Case study 1: Radio-ligand binding/competition assay.webp

  • Case study 2: Thymidine incorporation assay

    Case study 2: Thymidine incorporation assay.webp

  • Case study 3: Tissue distribution of 125I-labelled ADC

    Case study 3: Tissue distribution of 125I-labelled ADC-The labelling and purity of 125I-ADC.webp

    Case study 3: Tissue distribution of 125I-labelled ADC-Partial standard curve.webp

    Case study 3: Tissue distribution of 125I-labelled ADC.webp

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