Over 19 years of experience in R&D

01 Drug Discovery

Chemistry Research

Fee For Service(FFS)

Full Time Equivalent(FTE)

Computational Biology & Molecular Modeling

Enzymology & Molecular Interactions

Early Pharmacokinetics

02 Pharmaceutical Research

Intermediates

Active Pharmaceutical Ingredients

Route Selection

Production Process Optimization

Clinical Sample Production

Impurity Traceability & Control

Generic Drug Process Study & Filing

Innovative Drug Process Study & Filing

Pharmaceutical preparation

Preformulation Study

Formulation Technology Research

Preparation Quality Research

Laboratory-scale Preparation Testing

Pilot-scale Preparation Testing

GMP-based Clinical Sample Production & Packaging

Formulation Stability Study

Consistency Evaluation

Analytical Method Development and Quality Control

CMC Filings

03 Preclinical Research

Pharmacology & Pharmacodynamics

Tumor Models

Digestive System Disease Models

Endocrine & Metabolic Disease Models

Inflammatory & Immune Diseases Models

Neural System Disease Models

Other Disease Models

Ocular Diseases Models

Cardiovascular Model

Drug Safety Evaluation

Pharmacology & Toxicology Study

Safety Pharmacology

Histopathological Study

Clinicopathological Study

Drug Safety Evaluation Basic Information

Toxicokinetics

Pharmacokinetics

In Vitro Pharmacokinetic Assays

In Vivo Pharmacokinetic Assays

Bioanalysis

Macromolecular Drugs Bioanalysis

Micromolecular Drugs Bioanalysis

IND Filings

01 One-stop Integrated Services

Drug Discovery Platform

Pharmaceutical Research Platform

Preclinical Research Services

Chemical Drug Development

One-stop API Process R&D Department

Medicilon's CDMO Service Platform

Pharmaceutical Research CDMO Service Platform

Translational Medicine Platform

02 Innovative Drug Services

Nucleic Acid Drug R&D Platform

Non-clinical Research for Cellular Immunotherapies

mRNA Vaccine Bioanalysis Platform

PROTAC Drug Discovery Research Platform

ADC R&D Service Platform

03 Key Technical Services for Drug R&D

Green Chemistry Platform

Process Department Solid Form Screening Platform

SEND Format Conversion Platform

Flow Cytometry Technology Platform

Safety Assessment Lab of Process Chemistry

Drug Forming Research Platform

Metabolite Identification (MetID) Service Platform

Cytokine and Biomarker Detection Platform

04 Drug Efficacy Evaluation for Common Diseases

Rodent Cerebrovascular Disease Drug Efficacy Evaluation System

Pharmacodynamic Evaluation Model Platform for Inflammatory and Immune Diseases

IO Pharmacodynamic Model Evaluation Platform

05 Advanced Preparation R&D

Skin Topical Preparation R&D

Ophthalmic drug R&D platform

Inhalation drug R&D platform

06 Drug Analysis

07 Public Services

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U.S.

Address: 1 Broadway, Cambridge, MA02142 (America)

Tel: +1(626)986-9880

Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK

Tel: 0044 7790 816 954

Email: marketing@medicilon.com

China

Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)

Postcode: 201299

Tel: +86 (21) 5859-1500 (main line)

Fax: +86 (21) 5859-6369

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Protein Expression and Purification

We have rich experience in the expression and purification of recombinant proteins. We are proud of our various protein expression systems, including our prokaryotic protein expression system, yeast protein expression system, insect cell protein expression system (baculovirus), and mammalian cell protein expression system. In addition, we have employed fusion technologies to provide our clients with more options in terms of protein expression and purification. We tailor our service for your project at different dimensions including the scheme design, gene optimization, expression condition optimization, and purification technology system of your target protein expression level.

Services

Protein Purification
We provide affinity chromatography purification for tag protein, which purifies the expressed recombinant protein by means of molecular exclusion chromatography (molecular sieve), ion exchange chromatography, hydrophobic chromatography, and gel filtration, to remove the unnecessary purified tags.
Molecular exclusion chromatography (molecular sieve)Ion exchange chromatography (IEX)Hydrophobic chromatography Gel filtration
Customized protein purification Protein purification is an important step. Choosing an appropriate method is helpful to obtain better protein products. As for the choice of methodology, you can make your request and discuss with us. The purified protein can be used in follow-up experiments such as compound screening, activity detection, structure research, antibody preparation, ICH, cell experiment, protein interaction research and drug target research. Flexible selection of protein purification tags The selection of protein expression purification tags will have a certain impact on protein expression, solubility, and the follow-up application of protein. Medicilon can offer flexible tag selection (tags such as his, GAT, MBP and sumo)
Preparation of recombinant kinase
Various expression systems: insect cell, HEK293 cell and E.coliHoloenzyme or kinase Inhibitor selection level or structural biological level