Over 19 years of experience in R&D

01 Drug Discovery

Chemistry Research

Synthetic Chemistry

Medicinal Chemistry

Analytical Chemistry

Full Time Equivalent(FTE)

Fee For Service(FFS)

Catalyst Screening

Enzyme Catalysis

Continuous Flow Chemical Technology

Biology Research

Structural Biology

Cell Biology

Enzymology & Molecular Interactions

Antibody Discovery

Translational Medicine

High Throughput Screening

Computational Biology & Molecular Modeling

Early Pharmacokinetics

Radiolabel ADME

02 Pharmaceutical Research

Intermediates

Active Pharmaceutical Ingredients

Route Selection

Production Process Optimization

Clinical Sample Production

Impurity Traceability & Control

Generic Drug Process Study & Filing

Innovative Drug Process Study & Filing

Pharmaceutical preparation

Consistency Evaluation

Preformulation Study

Formulation Stability Study

GMP-based Clinical Sample Production & Packaging

Pilot-scale Preparation Testing

Laboratory-scale Preparation Testing

Preparation Quality Research

Formulation Technology Research

Analytical Method Development and Quality Control

CMC Filings

03 Preclinical Research

Pharmacology & Pharmacodynamics

Tumor Models

Digestive System Disease Models

Endocrine & Metabolic Disease Models

Inflammatory & Immune Diseases Models

Neural System Disease Models

Other Disease Models

PDXO Models

Ocular Diseases Models

Cardiovascular Model

Drug Safety Evaluation

Pharmacology & Toxicology Study

Safety Pharmacology

Histopathological Study

Clinicopathological Study

Drug Safety Evaluation Basic Information

Toxicokinetics

DMPK

In Vitro ADME Assays

In Vivo Pharmacokinetic Assays

Bioanalysis

Macromolecular Drugs Bioanalysis

Micromolecular Drugs Bioanalysis

IND Filings

01 One-stop Integrated Services

Drug Discovery Platform

Pharmaceutical Research Platform

Preclinical Research Services

Chemical Drug Development

One-stop API Process R&D Department

CDMO Service Platform

Pharmaceutical Research CDMO Service Platform

Translational Medicine Platform

Botanical Drug Preclinical R&D Technology Platform

02 Innovative Drug Services

ADC R&D Service Platform

PROTAC R&D Service Platform

mRNA Vaccine Bioanalysis Platform

Non-clinical Research for Cellular Immunotherapies

Nucleic Acid Drug R&D Platform

Peptide Drug Conjugate (PDC) R&D Service Platform

Antibody R&D Service

03 Key Technical Services for Drug R&D

Cytokine and Biomarker Detection Platform

Metabolite Identification (MetID) Service Platform

Drug Forming Research Platform

Safety Assessment Lab of Process Chemistry

Flow Cytometry Technology Platform

SEND Format Conversion Platform

Process Department Solid Form Screening Platform

Green Chemistry Platform

Flow Sorting Platform

NanoString nCounter Detection Platform

Routes of Drug Administration Platform

Drug Solid-State Research Service Platform

04 Drug Efficacy Evaluation for Common Diseases

IO Pharmacodynamic Model Evaluation Platform

Pharmacodynamic Evaluation Model Platform for Inflammatory and Immune Diseases

Rodent Cerebrovascular Disease Drug Efficacy Evaluation System

05 Advanced Preparation R&D

Inhalation drug R&D platform

Ophthalmic drug R&D platform

Skin Topical Preparation R&D Platform

06 Targeted Drugs R&D Services

STAT3-targeted Drugs R&D Service

GLP-1 New Drug R&D Service

KRAS-targeted Drugs R&D Service

07 Drug analysis platform

08 Public Services

CLIENT CENTER

Intellectual Property Protection

U.S.

Address: 50 Soldiers Field Place, Boston, MA 02135 (America)

Tel: +1(626)986-9880

Address: Allia Future Business Centre Kings Hedges Road Cambridge CB4 2HY, UK

Tel: 0044 7790 816 954

Email: marketing@medicilon.com

China

Address: No.585 Chuanda Road, Pudong New Area, Shanghai (Headquarters)

Postcode: 201299

Tel: +86 (21) 5859-1500 (main line)

Fax: +86 (21) 5859-6369

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Protein Expression and Purification

We have significant experience in the expression and purification of recombinant proteins. We utilise various protein expression modalities, including prokaryotic protein expression, yeast protein expression, insect cell protein expression (baculovirus), and mammalian cell protein expression systems. In addition, we have employed fusion technologies to provide our clients with more options in terms of protein expression and purification. We tailor our service for your project including the design, gene optimization, expression condition optimization, and purification technology system to deliver your target protein quality and expression level.

Services

Protein Purification
We provide affinity chromatography purification for tag protein, which purifies the expressed recombinant protein by means of molecular exclusion chromatography, ion exchange chromatography, hydrophobic chromatography, and gel filtration, to remove the unnecessary purified tags.
Molecular exclusion chromatography (molecular sieve)Ion exchange chromatography (IEX)Hydrophobic chromatography Gel filtration
Customized protein purification Protein purification is a critical step. Choosing an appropriate method is essential to obtain superior protein products andr the choice of methodology, can be selected in discussion with our expert team. The purified protein can be used in follow-up experiments such as compound screening, activity detection, structure research, antibody preparation, ICH, cell experiment, protein interaction research and drug target research. Flexible selection of protein purification tags The selection of protein expression purification tags will have an impact on protein expression, solubility, and the follow-up application of protein. Medicilon can offer flexible tag selection including his, GAT, MBP and sumo options.
Preparation of recombinant kinase
Various expression systems: insect cell, HEK293 cell and E.coliHoloenzyme or kinase Inhibitor selection level or structural biological level