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Isotope-labeled Internal Standards Synthesis

Isotope-labeled Internal Standards Synthesis

Medicilon provides synthesis services of standards and isotope internal standards, and offers professional services in the design, synthesis, preparation and release of radiolabeled compounds of synthetic routes.

At the same time, Medicilon has the capability of isotope pharmacokinetic analysis of innovative drugs and has served the new drug development and marketing applications of many pharmaceutical companies. Medicilon has an advanced laboratory capable of isotope pharmacokinetic analysis of innovative drugs and an integrated service platform integrating isotope synthesis, labeling, testing, and analysis, providing comprehensive technical support for the research and development of new drugs such as antibodies and vaccines.
Services include:
  • 1. Synthesis services of standards and isotope internal standards
    Medicilon’s Chemical Synthesis and Radiosynthesis Laboratory can provide short-term and rapid synthesis services of standards and isotope internal standards. Synthesis services include but are not limited to isotope labeling position selection, synthesis route optimization, isotope product purification and analysis, and isotope labeling biomacromolecule R&D services.
  • 2. Pharmaceutical research and analysis services of radioisotope
    Pharmaceutical research and analysis services of radioisotope, using 32P、33P 、125I、35S、89Zr and other radioactive isotopes for labeling experiments in the drug development process, including:
    Distribution, metabolism and pharmacokinetics of drugs in vivoRadioreceptor assayRadioligand binding testRadioactive uptake testingCell growth testRadioimmunoassayImmunoradiation analysis, etc.
    In addition,we have a radioisotope (125I, 14C, 3H) research license for studying material balance and tissue distribution.
  • 3. Synthesis of radiolabeled compounds
    Medicilon can provide synthesis of aromatic compounds, heterocyclic compounds, polypeptides, oligonucleotides, conjugates, and polymers, including chiral compounds, antibody-drug conjugates (ADCs), and their linkers.Medicilon can provide a wide range of analytical methods and develop special technologies (including GLP analysis) such as Infrared spectroscopy, mass spectrometry, liquid chromatography (radioactivity detection and polymer characterization), gas chromatography, NMR differential scanning calorimetry, thermogravimetric analysis and ICP-MS, bioburden test and XRPD analysis.
Advantage:
  • Rich experience in chemical synthesis combined with efficient isotopic labeling chemistry.     Medicilon can provide customers with laboratories that comply with GLP and GMP standards to complete radiolabeled chemical projects.     Medicilon tracks the progress of isotope labeling chemistry and can quickly provide customers with a variety of isotope labeling intermediates.
Relevant laboratories
  • NMR
  • chemistry lab
  • GC-MS
  • NMR-BRUKER
  • high-activity-laboratory
Relevant articles