Synthetic Chemistry

Download

Service

• Synthesis of high-quality compounds from milligram to kilogram
  Synthesis of reagents, intermediates, building blocks, reference compounds, metabolites, and impurities
• Scaling up Compound Production to Non-GMP Level
• Custom chemical synthesis
  Synthesis of molecules with a completely new structureSynthesis of positive compounds and molecular probesSynthesis of special reagents, intermediates, and molecular fragments Preparation of API or related substances Synthesis of standard substancesSynthesis design and preparation of impurities or metabolitesSynthesis of stable isotope internal standards Synthesis of SIL internal standards Synthesis of tritiated compounds Synthesis and resolution of chiral compounds Analytical support Delivery of the product analysis report Expertise: chiral drugs, heterocyclic chemistry, carbohydrate chemistry, nucleoside chemistry, peptide chemistry and antibody drug conjugation (ADC)
• Scale up
  Scaling-up synthesis and process optimization of preclinical candidate compoundsSynthesis of high-quality kilogram-level samplesResearch on target compound synthesis technology

Product List

Inquiry

• Medicilon intermediate product list

  Number	Compound Name	Purity	Inventory
  1	4-(methoxycarbonyl)benzyl 1H-indole-4-carboxylate	88.91	5.5 g
  2	4-(methoxycarbonyl)benzyl 1H-indazole-4-carboxylate	85.34	4.7 g
  3	2-chloro-5-(4-fluorophenyl)thiazole-4-carbonitrile	97.97	2 g
  4	2-(5-((3-((2H-tetrazol-5-yl)methoxy)azetidin-1-yl)sulfonyl)-2-ethoxyphenyl)-5-methyl-7-propyl-4a,7-dihydroimidazo[5,1-f][1,2,4]triazin-4(3H)-one	99.28	2 g
  5	2-((1-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4,4a,7-tetrahydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)azetidin-3-yl)oxy)acetonitrile	99.76	2 g
  6	2-(5-((3-((1H-1,2,3-triazol-4-yl)methoxy)azetidin-1-yl)sulfonyl)-2-ethoxyphenyl)-5-methyl-7-propyl-4a,7-dihydroimidazo[5,1-f][1,2,4]triazin-4(3H)-one	98.86	4.5 g
  7	2-(5-((3-aminoazetidin-1-yl)sulfonyl)-2-ethoxyphenyl)-5-methyl-7-propyl-4a,7-dihydroimidazo[5,1-f][1,2,4]triazin-4(3H)-one	98.98	1.5 g
  8	methyl 4-(3-(4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)prop-1-yn-1-yl)-3-((2-methoxyethoxy)methyl)benzoate	96.43	0.5 g
  9	methyl 4-(3-(4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)prop-1-yn-1-yl)-3-((4-methoxybutoxy)methyl)benzoate	96.73	0.46 g
  10	4-(3-(4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)prop-1-yn-1-yl)-3-((2-methoxyethoxy)methyl)benzoic acid	97.16	0.03 g
  11	methyl 4-(3-(4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)prop-1-yn-1-yl)-3-((3-methoxypropoxy)methyl)benzoate	95.65	0.05 g
  12	4-((3-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonamido)azetidin-1-yl)methyl)-3-fluoro-N-hydroxybenzamide	95.97	0.2 g
  13	methyl 6-(((1-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)azetidin-3-yl)amino)methyl)nicotinate	\	0.44 g
  14	4-(methoxycarbonyl)benzyl 1H-indole-6-carboxylate	97.47	1.6 g
  15	4-(methoxycarbonyl)benzyl 1H-indazole-6-carboxylate	95.72	1.7 g
  16	2-(5-((3-((2H-tetrazol-5-yl)methyl)-3-hydroxyazetidin-1-yl)sulfonyl)-2-ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one	96.12	6 g
  17	2,2-dimethyl-4-nitrobutanoic acid	\	2.5 g
  18	4-(methoxycarbonyl)benzyl 1H-indole-5-carboxylate	95.04	2.4 g
  19	4-(methoxycarbonyl)benzyl 1H-indazole-5-carboxylate	70	3 g
  20	2-(5-chloro-2-ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one	79.236	0.9 g
  21	2-(2-ethoxy-5-iodophenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one	98.575	5.3 g
  22	2-chloro-8-cyclopentyl-6-iodo-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one	94.943	2.2 g
  23	N-(5-(4-aminobutyl)pyridin-2-yl)-5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidin-2-amine	99.207	1.1 g
  24	2-chloro-5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidine	93.522	6.1 g
  25	4-chloro-5-fluoro-N-(5-nitropyridin-2-yl)pyrimidin-2-amine	87.86	3.4 g
  26	4-(3-(5-((4-(3-(dimethylamino)azetidin-1-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-2-yl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile	100	0.12 g
  27	4-(3-((5-((5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidin-2-yl)amino)pyridin-2-yl)methyl)-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile	90.453	0.1 g
  28	methyl 4-(((1-((4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenyl)sulfonyl)azetidin-3-yl)amino)methyl)-3-fluorobenzoate	99.188	16 g
  29	2-(5-bromo-2-ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one	97.927	1.9 g
  30	2-(5-amino-2-ethoxyphenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one	85.65	33.4 g
  31	methyl 1-(5-bromopyridin-2-yl)piperidine-4-carboxylate	100	16.2 g
  32	3-(2-((3-(4-(ethoxycarbonyl)phenoxy)phenyl)amino)-2-oxoethyl)-1H-indole-2-carboxylic acid	90	310 mg
  33	methyl 3'-nitro-[1,1'-biphenyl]-3-carboxylate	92	630 mg
  34	3-(2-((3'-(1-methoxyvinyl)-[1,1'-biphenyl]-3-yl)amino)-2-oxoethyl)-1H-indole-2-carboxylic acid	93	270 mg
  35	3-(2-((3-(2-(methoxycarbonyl)phenoxy)phenyl)amino)-2-oxoethyl)-1H-indole-2-carboxylic acid	92	150 mg
  36	methyl 4,6-dichloropicolinate	100	120 mg
  37	(R)-4-(5-chloropyrazolo[1,5-a]pyrimidin-7-yl)-3-methylmorpholine	100	120 mg
  38	(S)-4-(3,6-dichloropyridazin-4-yl)-3-methylmorpholine	94	110 mg
  39	3-(6-chloro-5-morpholinopyridazin-3-yl)-8-oxa-3-azabicyclo[3.2.1]octane	99	120 mg
  40	5-chloro-7-(cyclopropylsulfonyl)pyrazolo[1,5-a]pyrimidine	98	110 mg
  41	5-bromopyrazolo[1,5-a]pyridine	100	120 mg
  42	(R)-4-(7-iodopyrazolo[1,5-a]pyrimidin-5-yl)-3-methylmorpholine	90	108 mg
  43	4-bromo-3,6-dichloropyridazine	90	104 mg
  44	(1R,5S)-3-(4-((R)-3-methylmorpholino)-7-(1H-pyrazol-3-yl)imidazo[1,5-b]pyridazin-2-yl)-8-oxa-3-azabicyclo[3.2.1]octane	85	111 mg
  45	(1R,5S)-3-(pyrazolo[1,5-a]pyrimidin-5-yl)-8-oxa-3-azabicyclo[3.2.1]octane	95	108 mg
  46	4-(3,6-dichloropyridazin-4-yl)-2-methylmorpholine	90	106 mg
  47	N-((6-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-(2-methylmorpholino)pyridazin-3-yl)methyl)-1H-pyrazole-5-carboxamide	90	133 mg
  48	8-chloro-2-morpholino-1,7-naphthyridin-4-ol	90	101 mg
  49	3,6-dichloro-4-(piperidin-1-yl)pyridazine	95	105 mg
  50	7-benzyl-3-chloroisoquinoline	95	102 mg
  51	2-(2,6-dioxopiperidin-3-yl)-5-(4-(hydroxymethyl)piperidin-1-yl)isoindoline-1,3-dione	90	109 mg
  52	3-(6-chloro-5-(3,3-dimethylmorpholino)pyridazin-3-yl)-8-oxa-3-azabicyclo[3.2.1]octane	90	133 mg
  53	2-(2,6-dioxopiperidin-3-yl)-5-(3-(hydroxymethyl)azetidin-1-yl)isoindoline-1,3-dione	90	112 mg
  54	5-(3,6-dihydro-2H-pyran-4-yl)pyrazolo[1,5-a]pyrimidine	90	120 mg
  55	N-(2,3-dihydro-1H-inden-4-yl)pivalamide	90	145 mg
  56	N-(5-bromo-2,3-dihydro-1H-inden-4-yl)pivalamide	90	130 mg
  57	1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbaldehyde	90	119 mg
  58	piperidin-4-yl 4-methylbenzenesulfonate hydrochloride	90	126 mg
  59	2-(2,6-dioxopiperidin-3-yl)-5-(4-((4-hydroxypiperidin-1-yl)methyl)piperidin-1-yl)isoindoline-1,3-dione	90	103 mg
  60	2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione	90	136 mg
  61	(R)-4-(5-chloropyrazolo[1,5-a]pyrimidin-7-yl)-3-methylmorpholine	95	103 mg
  62	methyl 3'-(methylsulfonyl)-[1,1'-biphenyl]-4-carboxylate	92	516 mg
  63	1-(4-([1,1'-biphenyl]-4-yloxy)-2-bromophenyl)ethan-1-one	90	140 mg
  64	3-(4-nitrophenoxy)aniline	99	588 mg
  65	methyl 3-methyl-1H-indole-2-carboxylate	100	130 mg
  66	methyl 6-(pyridin-4-yl)-1H-indole-2-carboxylate	95	310 mg
  67	methyl 6-(benzyloxy)-1H-indole-2-carboxylate	91	120 mg
  68	4-(3-nitrophenoxy)-1,1'-biphenyl	99	180 mg
  69	methyl 7-bromo-4-fluoro-3-(2-methoxy-2-oxoethyl)-1H-indole-2-carboxylate	100	140 mg
  70	3-(carboxymethyl)-6-phenethoxy-1H-indole-2-carboxylic acid	97	128 mg
  71	methyl 2-amino-[1,1'-biphenyl]-4-carboxylate	96	235 mg
  72	4-iodo-3-(trifluoromethyl)-1H-pyrazole	100	170 mg
  73	(R)-4-(3,6-dichloropyridazin-4-yl)-3-methylmorpholine	98.28	200 mg
  74	3,6-dichloro-N-((5-methylimidazo[1,2-a]pyridin-2-yl)methyl)pyridazin-4-amine	100	114 mg
  75	ethyl 5-((tert-butoxycarbonyl)amino)pyrazolo[1,5-a]pyridine-3-carboxylate	98.84	150 mg
  76	3-(2,6-difluoro-4-iodopyridin-3-yl)-N-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)propanamide	98.77	185 mg
  77	3-(6-chloro-5-(4,4-difluoropiperidin-1-yl)pyridazin-3-yl)-8-oxa-3-azabicyclo[3.2.1]octane	96.34	135 mg
  78	(2S,6R)-4-(3,6-dichloropyridazin-4-yl)-2,6-dimethylmorpholine	99.53	670 mg
  79	tert-butyl 4-(5-chloropyrazolo[1,5-a]pyrimidin-7-yl)-3,6-dihydropyridine-1(2H)-carboxylate	99.09	820 mg
  80	3-(2,4-difluoro-6-iodophenyl)propanoic acid	92.14	1000 mg
  81	8-bromo-2,4-dichloro-1,5-naphthyridine	95.72	270 mg
  82	methyl 2-amino-4-bromo-3,5-difluorobenzoate	90	2.7 g
  83	4-(4-aminophenoxy)benzenesulfonamide	90	755 mg
  84	4-((4-chlorophenoxy)methyl)aniline	90	3.97 g
  85	3'-amino-[1,1'-biphenyl]-3-sulfonamide	90	4.91 g
  86	tert-butyl 4-(3-bromobenzoyl)piperazine-1-carboxylate	90	2.43 g
  87	methyl 6-(benzyloxy)-3-(2-methoxy-2-oxoethyl)-1H-indole-2-carboxylate	90	135 mg
  88	3-chloro-7-vinylisoquinoline	90	800 mg
  89	2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione	90	330 mg
  90	2-(2,6-dioxopiperidin-3-yl)-4-hydroxyisoindoline-1,3-dione	90	520 mg
  91	([1,1'-biphenyl]-3-ylmethyl)triphenylphosphonium bromide	98.5	1.543 g
  92	(4-phenoxybenzyl)triphenylphosphonium bromide	97.2	344 mg
  93	1-(tert-butyl) 2-methyl 3-formyl-1H-indole-1,2-dicarboxylate	93.5	1.167 g
  94	methyl 3-formyl-1H-indole-2-carboxylate	93.2	102 mg
  95	2-(2,6-dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione	86.4	242 mg
  96	((4'-(methoxycarbonyl)-[1,1'-biphenyl]-2-yl)methyl)triphenylphosphonium bromide	94.3	1.215 g
  97	methyl 6-formyl-1H-indole-2-carboxylate	95.6	777 mg
  98	methyl 3'-nitro-[1,1'-biphenyl]-2-carboxylate	96.5	243 mg
  99	methyl (E)-3-(4-(([1,1'-biphenyl]-3-yloxy)methyl)phenyl)-2-azidoacrylate	83.6	221 mg
  100	4-(benzyloxy)-2-nitrobenzenediazonium tetrafluoroborate	84.3	1.744 g
  101	6-(benzyloxy)-3-(carboxymethyl)-1H-indole-2-carboxylic acid	98.7	230 mg
  102	methyl 5-(pyridin-4-yl)-1H-indole-2-carboxylate	100	215 mg
  103	methyl 4-amino-5-bromo-1,2-dihydropyridazine-3-carboxylate	99.157	230 mg
  104	2-(methoxycarbonyl)-1H-indole-6-carboxylic acid	97.1	222 mg
  105	2,4-dichloro-7-methoxy-1,8-naphthyridine	86.6	180 mg
  106	3-methylthiomorpholine 1,1-dioxide hydrogen chloride	98.2	200 mg
  107	3,3'-(3-iodopyrazolo[1,5-a]pyrimidine-5,7-diyl)bis(6-oxa-3-azabicyclo[3.1.1]heptane)	98.3	100 mg
  108	4-([1,1'-biphenyl]-4-yloxy)benzaldehyde	98	160 mg
  109	1-(tert-butyl) 2-methyl 6-bromo-1H-indole-1,2-dicarboxylate	100	180 mg
  110	methyl 6-bromo-1H-indole-2-carboxylate	89	140 mg
  111	methyl 6-([1,1'-biphenyl]-4-yloxy)-1H-indole-2-carboxylate	99	100 mg
  112	4-([1,1'-biphenyl]-3-yloxy)benzaldehyde	100	450 mg
  113	4-amino-3-nitrobenzaldehyde	98	120 mg
  114	3-(carboxymethyl)-1H-indole-2-carboxylic acid	100	130 mg
  115	3-(carboxymethyl)-1-isobutylindoline-2-carboxylic acid	100	130 mg
  116	4-(3-nitrobenzyl)morpholine	100	250 mg
  117	6-chloro-3-fluoro-5-vinylpyridin-2-amine	95	110 mg
  118	3-(4-aminophenoxy)benzenesulfonamide	90	11.2 g
  119	4-(difluoromethoxy)-3-isopropoxybenzoic acid	86.78	1.981 g
  120	2-(3-methylisothiazol-5-yl)isoindoline-1,3-dione	91.94	2.232 g
  121	N-((1H-1,2,4-triazol-3-yl)methyl)-2-ethoxybenzamide Molecular Weight: 246.27	87.14	1.025 g
  122	3-(benzyloxy)-4-(difluoromethoxy)benzamide	88.43	456 mg
  123	4-(3-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(2H-tetrazol-2-yl)propyl)bicyclo[1.1.1]pentan-1-yl)phenol	83.68	419 mg
  124	methyl 5-cyanoquinoline-6-carboxylate	98.97	1.298 g
  125	6-aminoquinoline-5-carbonitrile	98.09	2.017 g
  126	2-ethoxy-N-(prop-2-yn-1-yl)benzamide	99.04	6.228 g
  127	7a,9,10,11,12,12a-hexahydro-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one	100	466 mg
  128	(2-fluoro-6-methoxypyridin-3-yl)boronic acid	94.8	1080 mg
  129	3-bromo-5-(naphthalen-1-yl)pyridine	96.3	1010 mg
  130	ethyl 2-(7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl)oxazole-5-carboxylate	97.3	165 mg
  131	4-bromo-2-ethoxyphenol	92.71	3470 mg
  132	2-(7-methoxy-3H-spiro[benzofuran-2,1'-cyclopentan]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	97.28	12.182 g
  133	2-(8-methoxy-2,2-dimethylchroman-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	87.42	1.372 g
  134	5-bromo-2-methoxyphenol	100	2.171 g
  135	5-iodo-7-methoxy-3-methyl-3H-imidazo[4,5-b]pyridine	96	168 mg
  136	2-bromo-6-fluoro-4-(trifluoromethyl)benzoic acid	100	1.9 g
  137	tert-butyl (4-bromo-2,2,5-trifluoro-1-oxido-3-oxo-2,3-dihydro-1l4-benzo[b]thiophen-1-ylidene)carbamate	100	2.2 g
  138	5-bromo-8-methoxy-2-(trifluoromethyl)quinoline	96.32	25.961 g
  139	5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-amine	95	4.3 g
  140	2-(5-amino-3-methyl-1H-pyrazol-1-yl)-6-propylpyrimidin-4(3H)-one	95	1.2 g
  141	6-chloro-N-cyclohexyl-2-(pyridin-2-yl)pyrimidin-4-amine	95	4.1 g
  142	N-(5-bromoquinolin-8-yl)-4-methylbenzenesulfonamide	90	640 mg
  143	3-chloro-6-(methylthio)-N-(tetrahydro-2H-pyran-4-yl)pyrazine-2-carboxamide	95	360 mg
  144	3-chloro-N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-N-methylbenzamide	95	70 mg
  145	N-(3-methyl-1-(6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)-1H-pyrazol-5-yl)thiazole-2-carboxamide	95	188 mg
  146	5-(2-methoxyphenyl)-N-(1-methyl-1H-benzo[d]imidazol-2-yl)-1,3,4-oxadiazol-2-amine	93	132 mg
  147	N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)tetrahydro-2H-pyran-4-carboxamide	95	50 mg
  148	N-(5-(2-methoxyphenyl)-1,3,4-oxadiazol-2-yl)isobutyramide	94	134 mg
  149	N-(5-bromoquinolin-8-yl)tetrahydro-2H-pyran-4-sulfonamide	95	72 mg
  150	2-(pyridin-2-yl)pyrimidine-4,6-diol	90	4.1 g
  151	5-bromo-6-nitroquinoline	90	1.3 g
  152	6,7-dimethoxy-2-methylquinazolin-4-ol	100	11.3 g
  153	7-(benzyloxy)-6-methoxy-2-methylquinazolin-4-ol	75	3.2 g
  154	tert-butyl (S)-3-((7-methoxy-2-methyl-4-(((R)-1-(3-nitro-5-(trifluoromethyl)phenyl)ethyl)amino)quinazolin-6-yl)oxy)pyrrolidine-1-carboxylate	97	4.6 g
  155	(S)-tetrahydrofuran-3-yl methanesulfonate	\	3.5 g
  156	tert-butyl (R)-3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate	\	28.3 g
  157	4-(benzyloxy)-5-hydroxy-2-nitrobenzoic acid	85	9.5 g
  158	2-(3-azido-2-hydroxypropyl)isoindoline-1,3-dione	100	1.2 g
  159	2-hydroxy-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide	94	136 mg
  160	4-(bis(4-methoxybenzyl)amino)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one	99	110 mg
  161	4-amino-1-(3-fluoro-4-(pyrrolidin-1-ylmethyl)benzyl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one	98	105 mg
  162	4-(2-(dimethylamino)ethoxy)benzonitrile	93	171 mg
  163	2-(ethylthio)-1-(4-(pyrrolidin-1-ylmethyl)benzyl)-1H-imidazo[4,5-c]quinolin-4-amine	97	75 mg
  164	tert-butyl 4-((5-cyanothiophen-2-yl)methyl)piperazine-1-carboxylate	99	105 mg
  165	6-butoxy-1-(4-(pyrrolidin-1-ylmethyl)benzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine	100	110 mg
  166	ethyl (Z)-4-((phenyldiazenyl)methyl)benzoate	93	135 mg
  167	2-(chloromethyl)isoindoline-1,3-dione	90	4.5 g
  168	2-(chloromethyl)isoindoline-1,3-dione	90	8.0 g
  169	2-(chloromethyl)isoindoline-1,3-dione	90	6.9 g
  170	2,2'-(pyridin-2-ylmethylene)diphenol	98	7.4 g
  171	2,2'-(pyridin-2-ylmethylene)diphenol	98	1.5 g
  172	benzyl(2-bromoethyl)sulfane	90	5.7 g
  173	2-(chloromethyl)-1H-benzo[d]imidazole	90	4.28 g
  174	5-fluoro-3-nitropicolinonitrile	95	9.7 g
  175	5-bromo-3-(1,3-dioxolan-2-yl)-2-fluoropyridine	94	2.28 g
  176	4-fluoroquinoline	94	2.9 g
  177	2-cyclobutylacetonitrile	\	8.24 g
  178	methyl (E)-4-bromo-3-((2-methyl-3-phenylallyl)oxy)benzoate	\	4.295 g
  179	(Z)-N-((methylsulfonyl)oxy)acetimidoyl chloride	\	8.44 g
  180	3-benzyl-3-methyl-2,3-dihydrobenzofuran-6-carboxylic acid	96	556 mg
  181	2-((5-bromo-2-nitrophenyl)amino)-N-(2-hydroxyethyl)acetamide	95	110 mg
  182	tert-butyl 4-(cyanomethylene)piperidine-1-carboxylate	95	100 mg
  183	potassium (3,5-dimethylisoxazol-4-yl)trifluoroborate	95	19 g
  184	methyl 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylate	90	219.84 mg
  185	ethyl (E)-3-(3,5-dichlorophenyl)acrylate	90	1986.44 mg
  186	3-(1-oxo-5-vinylisoindolin-2-yl)piperidine-2,6-dione	90	831.19 mg
  187	3-(4-methoxybenzyl)imidazolidine-2,4-dione	90	4484.23 mg
  188	5-(4-chlorophenyl)-1,3,4-oxadiazol-2-amine	90	39.13 mg
  189	2-oxo-2-(pyridin-3-yl)acetic acid	90	1428.28 mg
  190	2,2,5-tribromo-2,3-dihydro-1H-inden-1-one	90	1622.07 mg
  191	2,5-dibromo-2,3-dihydro-1H-inden-1-one	90	3929.72 mg
  192	3-bromopiperidine-2,6-dione	90	321.23 mg
  193	(E)-2-styrylthiophene	90	3319.16 mg
  194	1-oxo-2,3-dihydro-1H-indene-5-carbonitrile	90	1328.26 mg
  195	2-chloro-1-(3-hydroxyazetidin-1-yl)ethan-1-one	95	2.73 g
  196	2-((2-cyclopropyl-8-fluoro-6-(4-(2-oxopropyl)piperazin-1-yl)quinolin-4-yl)(ethyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile	95	140 mg
  197	2-((2-cyclopropyl-8-fluoro-6-(4-(2-hydroxypropyl)piperazin-1-yl)quinolin-4-yl)(ethyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile	97	75 mg
  198	6-bromo-2-cyclopropyl-8-fluoro-N-methylquinolin-4-amine	97	566 mg
  199	(9H-fluoren-9-yl)methyl (4-(chloromethyl)-2-methoxybenzyl)carbamate	93	410 mg
  200	tert-butyl (R)-(3-(benzyloxy)-2-hydroxypropyl)(2,4-dimethoxybenzyl)carbamate	95	150 mg
  201	tert-butyl (R)-(3-(benzyloxy)-2-hydroxypropyl)(2,4-dimethoxybenzyl)carbamate	95	4.28 g
  202	N-((4-bromophenyl)sulfonyl)-3-methylbutanamide	95	12.0 g
  203	methyl 5-(chloromethyl)-4'-(N-(3-methylbutanoyl)sulfamoyl)-[1,1'-biphenyl]-3-carboxylate	99	1.35 g
  204	methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-oxo-4,5-dihydrothiophene-3-carboxylate	98	370 mg
  205	methyl 4-(benzyloxy)-2,2-dimethylbutanoate	91	8.65 g
  206	N-(3-(((2-chloro-5-iodopyrimidin-4-yl)amino)methyl)pyrazin-2-yl)-N-methylmethanesulfonamide	72	1.44 g
  207	benzyl 3,3-difluorocyclobutane-1-carboxylate	80	17.4 g
  208	1-chloro-7-methoxyisoquinoline-6-carbonitrile	95	1.36 g
  209	methyl 3-bromo-5-(hydroxymethyl)benzoate	98	51.45 g
  210	2-methoxybenzyl carbamimidothioate hydrochloride	95	22.13 g
  211	tert-butyl 7-(methyl(7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-azaspiro[3.5]nonane-2-carboxylate	93	1000 mg
  212	methyl 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carboxylate	100	210 mg
  213	2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)aniline	97	900 mg
  214	2-methoxy-3-(1-methyl-1H-1,2,4-triazol-5-yl)aniline	95.7	500 mg
  215	N-(3-methoxy-1,2,4-thiadiazol-5-yl)-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.5]nonane-1-carboxamide	99	700 mg
  216	6-bromo-2-(2,6-dimethylpyridin-4-yl)-3-methyl-1H-indole	95	8.14 g
  217	6-(3-isopropyl-5-(piperidin-4-yl)-1H-indol-2-yl)-7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridine hydrochloride	95	1.05 g
  218	2-(4-(2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)acetamide	93	1.27 g
  219	6-bromo-3-(piperidin-1-ylmethyl)-1H-pyrrolo[2,3-b]pyridine	96	648 mg
  220	tert-butyl (2-((4-(1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamido)-6-(trifluoromethyl)pyridin-2-yl)oxy)ethyl)carbamate	95	295 mg
  221	tert-butyl (1R,5S)-3-(7-bromo-6-chloro-8-fluoroquinazolin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate	99	780 mg
  222	methyl 2-(1,4-dioxaspiro[4.5]decan-8-yl)-5-(6-(trifluoromethyl)picolinamido)-2H-indazole-6-carboxylate	95	35 mg
  223	N-(6-(2-hydroxypropan-2-yl)-2-(4-oxocyclohexyl)-2H-indazol-5-yl)-6-(trifluoromethyl)picolinamide	90	550 mg
  224	tert-butyl 4-hydroxy-2-(methylthio)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate	\	6.85 g+8.05 g
  225	tert-butyl (5-bromo-2-chloro-4-methylpyridin-3-yl)(tert-butoxycarbonyl)carbamate	\	8.23 g+5.10 g
  226	2-((4-chloropyrimidin-5-yl)oxy)-5-fluoro-N,N-diisopropylbenzamide	\	9.62 g
  227	tert-butyl (S)-10-bromo-11-chloro-8-(2-isopropylphenyl)-7-oxo-3,4,7,8,13,13a-hexahydropyrazino[2',1':3,4][1,4]oxazepino[5,6,7-de]quinazoline-2(1H)-carboxylate	\	1.47 g
  228	tert-butyl (5-bromo-4-chloropyridin-3-yl)(tert-butoxycarbonyl)carbamate	\	5.93 g
  229	7-fluoro-8-methylnaphthalen-1-yl trifluoromethanesulfonate	\	13.79 g
  230	methyl 2-((4-chloropyrimidin-5-yl)oxy)-5-fluorobenzoate	\	2.87 g
  231	7-bromo-5-fluoro-1-(2-isopropylphenyl)quinazoline-2,4(1H,3H)-dione	\	1.1 g
  232	6-amino-4-bromo-3-chloro-2-fluorobenzonitrile	\	2.55 g
  233	6-amino-4-bromo-3-chloro-2-fluorobenzonitrile	\	2.72 g
  234	2-amino-4-bromo-6-fluorobenzonitrile	\	6.2 g
  235	2-amino-4-bromo-6-fluorobenzonitrile	\	3 g
  236	(R)-(1-((3-methylpyrrolidin-1-yl)methyl)cyclopropyl)methanol	\	0.72 g
  237	(1-(morpholinomethyl)cyclopropyl)methanol	\	0.88 g
  238	(1-(pyrrolidin-1-ylmethyl)cyclopropyl)methanol	\	9.83 g
  239	(E)-1-(4-chloro-1-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)-1H-benzo[d][1,2,3]triazol-6-yl)-3-(dimethylamino)prop-2-en-1-one	\	0.26 g
  240	tert-butyl (tert-butoxycarbonyl)(4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate	\	1 g
  241	7-fluoro-8-methylnaphthalen-1-yl trifluoromethanesulfonate	\	1.7 g
  242	methyl 2-((2S,6S)-6-methyl-4-((4-nitrophenyl)sulfonyl)piperazin-2-yl)acetate	\	17 g
  243	1-benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate	\	3.8 g
  244	methyl 2-((2S,6S)-6-methyl-4-((4-nitrophenyl)sulfonyl)piperazin-2-yl)acetate	\	5.2 g
  245	(S)-1-((benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid	\	180 mg
  246	benzyl (S)-2-(cyanomethyl)piperazine-1-carboxylate	\	3.7 g
  247	2-amino-4-bromo-6-fluorobenzonitrile	\	6.2 g
  248	4-bromo-2,6-difluorobenzamide	\	5 g
  249	2-amino-3-methyl-5-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one	\	6.8 g
  250	1-bromo-8-chloronaphthalene	\	5.18 g
  251	8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione	\	1.7 g
  252	4-bromo-2,6-difluoro-N-((2-isopropylphenyl)carbamoyl)benzamide	\	3.3 g
  253	benzyl (2-chloro-9-isopropyl-9H-purin-6-yl)glycinate	\	0.86  g
  254	tert-butyl 4-(3,3-dimethylpiperazin-1-yl)benzoate	\	37.7 g
  255	4-(3,3-dimethylpiperazin-1-yl)benzoic acid	\	10 g
  256	6-(2,6-dichloro-3,5-dimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amine	\	15 g
  257	methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate	\	10 g
  258	tert-butyl 4-(4-((benzyloxy)carbonyl)piperazin-1-yl)-2-(methylsulfonyl)-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate	\	12 g
  259	2-(4-fluorobenzyl)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid	\	25 g
  260	benzyl (4-bromo-2-cyanophenyl)carbamate	\	20 g
  261	methyl 2-((2R,6R)-6-methyl-4-((4-nitrophenyl)sulfonyl)piperazin-2-yl)acetate	\	75 g
  262	methyl 2-((2R,6R)-6-methyl-4-((4-nitrophenyl)sulfonyl)piperazin-2-yl)acetate	\	23 g
  263	4-bromo-2,6-difluorobenzamide	\	21.6 g
  264	tert-butyl (2-bromo-9-isopropyl-9H-purin-6-yl)glycinate	\	50.5 g
  265	6-chloro-2-fluoro-9-isopropyl-9H-purine	\	31.6 g
  266	tert-butyl (2-chloro-9-isopropyl-9H-purin-6-yl)glycinate	\	130 g
  267	tert-butyl (2-bromo-9-isopropyl-9H-purin-6-yl)glycinate	\	164 g
  268	methyl (E)-3-(2-([1,1'-biphenyl]-3-yl)vinyl)-6-bromo-1H-indole-2-carboxylate	90	116 mg
  269	3-(carboxymethyl)benzofuran-2-carboxylic acid	90	1.2 g
  270	2'-methyl-[1,1'-biphenyl]-3-amine	90	150 mg
  271	methyl 3-(2-methoxy-2-oxoethyl)benzofuran-2-carboxylate	90	300 mg
  272	4-(o-tolyl)pyridin-2-amine	90	150 mg
  273	methyl (E)-6-bromo-3-(4-phenoxystyryl)-1H-indole-2-carboxylate	90	108 mg
  274	3-vinyl-1,1'-biphenyl	90	155 mg
  275	2-methyl-3'-vinyl-1,1'-biphenyl	90	190 mg
  276	1-phenoxy-2-vinylbenzene		101 mg
  277	4-(([1,1'-biphenyl]-2-yloxy)methyl)-2-bromobenzoic acid	95	120 mg
  278	methyl 3-(2-hydroxyethyl)-1H-indole-2-carboxylate	100	130 mg
  279	methyl 2'-amino-[1,1'-biphenyl]-4-carboxylate	95	130 mg
  280	3-(carboxymethyl)-1-ethyl-1H-indole-2-carboxylic acid	100	100 mg
  281	2-nitro-5-phenoxypyridine	99	130 mg
  282	1-(2-bromo-4-((2'-methyl-[1,1'-biphenyl]-3-yl)oxy)phenyl)ethan-1-one	95	100 mg
  283	methyl 6-benzyl-1H-indole-2-carboxylate	96	100 mg
  284	2-(methoxycarbonyl)-1H-indole-6-carboxylic acid	90	121 mg
  285	2-phenoxybenzaldehyde	100	221mg
  286	methyl 2-(2-([1,1'-biphenyl]-3-ylamino)-2-oxoethyl)-4-aminobenzoate	90	125 mg
  287	methyl 6-hydroxy-3-(2-methoxy-2-oxoethyl)-1H-indole-2-carboxylate	90	140 mg
  288	tert-butyl (6-(4-(hydroxymethyl)phenoxy)hexyl)carbamate	90	164 mg
  289	tert-butyl (4-(4-(hydroxymethyl)phenoxy)butyl)carbamate	90	329 mg
  290	6-((4-((8-aminooctyl)oxy)benzyl)oxy)-3-(4-phenoxyphenethyl)-1H-indole-2-carboxylic acid	90	45 mg
  291	6-((4-((8-aminooctyl)oxy)benzyl)oxy)-3-(2-oxo-2-((4-phenoxyphenyl)amino)ethyl)-1H-indole-2-carboxylic acid	90	127 mg
  292	5-methyl-2-nitrobenzenediazonium	90	500 mg
  293	4'-nitro-[1,1'-biphenyl]-4-ol	94.5	593 mg
  294	MC21-1687-033	90	111 mg
  295	MC-4034-118	90	122 mg
  296	MC211417-126	90	110 mg
  297	MC21-1702-023	90	106mg
  298	MC21-1702-027	90	110mg
  299	MC21-1686-048	90	137mg
  300	MC21-1686-033	90	106mg
  301	MC21-1659-012	90	105mg
  302	MC21-1659-040	90	103mg
  303	((benzyloxy)carbonyl)glycine	100	3 g
  304	2-chloro-3-nitro-N-(4-(pyrrolidin-1-ylmethyl)benzyl)quinolin-4-amine	92.7	1 g
  305	1-(4-aminobutyl)-2-(methylthio)-1H-imidazo[4,5-c]quinolin-4-amine	99	200 mg
  306	ethyl glycinate	98	1.5 g
  307	2-(methylthio)-1-((5-(pyrrolidin-1-ylmethyl)quinolin-8-yl)methyl)-1H-imidazo[4,5-c]quinolin-4-amine	98.3	89 mg
  308	5-methylquinoline-8-carbonitrile	100	383 mg
  309	2-butoxy-6-chloro-N,N-bis(4-methoxybenzyl)-5-nitropyrimidin-4-amine	100	337 mg
  310	8-bromo-5-methylquinoline	96.2	314 mg
  311	2-(butylthio)-6-chloro-N4,N4-bis(4-methoxybenzyl)pyrimidine-4,5-diamine	94.3	209 mg
  312	(2-amino-4-(methoxycarbonyl)phenyl)boronic acid	98.8	157 mg
  313	N-(4-(4-amino-2-(methylthio)-1H-imidazo[4,5-c]quinolin-1-yl)butyl)-4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamide	91.6	55mg
  314	methyl 4-carbamoyl-2-nitrobenzoate	99	185 mg
  315	tert-butyl 1-(9H-fluoren-9-yl)-3,7-dioxo-2,11,14-trioxa-4,8-diazaheptadecan-17-oate	98.7	210mg
  316	3-nitroquinoline-2,4-diol	99.6	250mg
  317	(6-(4-methylpiperazin-1-yl)pyridin-3-yl)methanamine	99.6	200mg
  318	tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate	88	141 mg
  319	methyl 4-(([1,1'-biphenyl]-3-yloxy)methyl)-2-bromobenzoate	98	350 mg
  320	4-(([1,1'-biphenyl]-3-yloxy)methyl)-2-bromo-N-methoxy-N-methylbenzamide	100	300 mg
  321	3-(carboxymethyl)-6-(trifluoromethyl)-1H-indole-2-carboxylic acid	94	50 mg
  322	6-benzyl-3-(1-carboxyethyl)-1H-indole-2-carboxylic acid	95	60 mg
  323	9H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-amine	93	213mg
  324	1-(2,4-bis(methoxymethoxy)phenyl)ethan-1-one	95	221 mg
  325	(S)-2-((naphthalen-1-yloxy)methyl)oxirane	97	221 mg
  326	(R)-2-((naphthalen-1-yloxy)methyl)oxirane	77	206 mg
  327	2-allyl-4-nitrophenol	99	210 mg
  328	pyrido[2,3-d]pyridazin-8(7H)-one	85	202 mg
  329	2-chloro-1H-benzo[d]imidazole-1-carbonitrile	99	221 mg
  330	3-(benzylamino)-1,1,1-trifluoropropan-2-ol	\	7.2 g
  331	methyl N-(tert-butoxycarbonyl)-O-(tert-butyldiphenylsilyl)-D-serinate	\	8.9 g
  332	methyl O-benzyl-N-(tert-butoxycarbonyl)-D-serinate	\	3.6 g
  333	2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine	\	6.5 g
  334	(tert-butoxycarbonyl)-L-proline	\	8 g
  335	tert-butyl piperidin-4-ylcarbamate	\	4.8 g
  336	4-(2-fluoropyridin-3-yl)-2-(methylthio)pyrimidine	100	110 mg
  337	2-methoxy-5-methyl-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline	100	200 mg
  338	tert-butyl (S)-4-(2-hydroxyquinoxalin-6-yl)-2-methylpiperazine-1-carboxylate	91	115 mg
  339	4-methylbenzyl carbamimidothioate	93	120 mg
  340	5-bromo-7-methoxy-2-methyl-2H-indazole	100	105 mg
  341	2,7-dimethylpyrazolo[1,5-a]pyridine-5-carbonitrile	100	103 mg
  342	(S)-6-(3-methylpiperazin-1-yl)benzo[d]thiazole	98	110 mg
  343	5-bromo-7-methoxy-1-methyl-1H-indazole	99	102 mg
  344	6-bromo-2-methylimidazo[1,2-a]pyrazine	95	150 mg
  345	tert-butyl (S)-4-(benzo[d]thiazol-6-yl)-2-methylpiperazine-1-carboxylate	90	202 mg
  346	5-bromopyrazin-2-amine	98	150 mg
  347	tert-butyl (S)-4-(6-aminopyridazin-3-yl)-2-methylpiperazine-1-carboxylate	99	100 mg
  348	7-methoxy-3-nitroquinolin-4-ol	94	105mg
  349	2-bromo-6-chloro-4-methylpyridin-3-amine	98	100 mg
  350	ethyl 4-chloro-6-fluoro-7-methoxyquinoline-3-carboxylate	98	110 mg
  351	N-(4-bromo-2,6-difluorobenzyl)-7-methoxy-3-nitroquinolin-4-amine	100	110 mg
  352	6-chloro-2,8-dimethylimidazo[1,2-b]pyridazine	99	113 mg
  353	tert-butyl (4-methoxypyridin-2-yl)carbamate	97	100 mg
  354	5-bromo-7-methoxy-2-methyl-2H-pyrazolo[3,4-c]pyridine	99	116 mg
  355	4-chloro-7-methoxy-3-nitroquinoline	98	150 mg
  356	N2-(4-chlorophenyl)-N6-cyclopropyl-3-nitropyridine-2,6-diamine	100	3.0g
  357	3-(4-(benzyloxy)phenyl)-4-iodo-1H-pyrazole	100	3.1g
  358	ethyl 5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxylate	91	2.9g
  359	6-chloro-2-iodo-N-(4-methoxybenzyl)pyrimidin-4-amine	91.27	4.8g
  360	2-methoxy-4-methylbenzoic acid	100	3.1g
  361	benzyl 4-(tosyloxy)piperidine-1-carboxylate	100	4.4g
  362	5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxylic acid	100	0.9g
  363	3-aminopicolinonitrile	100	1.3g
  364	5-bromo-2-methoxy-3-nitrobenzamide	74.48	2.1g
  365	ethyl 5-(2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate	100	1.3g
  366	2-(5,6-dichloropyridin-3-yl)acetonitrile	83.61	2.1g
  367	2-hydroxy-3-nitrobenzamide	98.9	8.1g
  368	4-iodo-3-(4-phenoxyphenyl)-1H-pyrazole	76.69	4.3g
  369	5-bromopicolinamide	100	4.6g
  370	2-chloro-5-nitropyridin-4-amine	100	4.5g
  371	3-aminopicolinamide	97.42	4.9g
  372	5-nitroisothiazole-3-carboxylic acid	100	5.2g
  373	tert-butyl 3-(2,5-dioxo-4-(pyridin-2-yl)imidazolidin-4-yl)propanoate	100	0.9g
  374	7-chloro-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one	100	2.6g
  375	methyl 6-chloro-4-((3-((2,2,2-trifluoroacetamido)methyl)phenyl)thio)pyridazine-3-carboxylate	100	0.3g
  376	3-aminopicolinamide	100	1.0g
  377	N-(5-bromo-8-(methylamino)-4a,8a-dihydropyrido[3,4-c]pyridazin-3-yl)cyclopropanecarboxamide	100	0.2g
  378	ethyl 5-amino-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylate	100	0.8g
  379	4-bromo-2-ethoxy-6-nitroaniline	100	2.9g
  380	tert-butyl (5-(4-aminopyrimidin-2-yl)thiazol-2-yl)(pent-4-en-1-yl)carbamate	100	2.0g
  381	N4-(1-methylpiperidin-4-yl)-5-(trifluoromethyl)benzene-1,2,4-triamine	94	0.9g
  382	5-bromo-2-hydroxy-4-methoxynicotinonitrile	84	0.2g
  383	1H-indol-4-amine	97.76	5.1g
  384	tert-butyl (1-(pyrimidin-2-yl)butyl)carbamate	100	3.0g
  385	1-(4-amino-5-nitropyridin-2-yl)piperidin-4-ol	100	0.6g
  386	tert-butyl (5-(4-aminopyridin-2-yl)thiazol-2-yl)(pent-4-en-1-yl)carbamate	94	0.6g
  387	5-(hydroxymethyl)-2-methylphenol	100	1.7g
  388	1-(2-chloro-5H-pyrrolo[2,3-d]pyrimidin-5-yl)propan-1-one	100	0.9g
  389	tert-butyl (5-(4-aminopyrimidin-2-yl)thiazol-2-yl)(pent-4-en-1-yl)carbamate	100	2.1g
  390	methyl 2-acrylamido-4-((tert-butoxycarbonyl)(2-(tosyloxy)propyl)amino)benzoate	100	0.6g
  391	N-(1-(4-bromobenzoyl)piperidin-4-yl)acetamide	100	0.6g
  392	4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridin-2(1H)-one	100	2.5g
  393	4-chloro-3-(6-(2-methyl-6-methylenemorpholino)-1H-imidazo[4,5-c]pyridin-2-yl)-3,4-dihydroquinolin-2(1H)-one	40	1.2g
  394	2-methoxy-1-(pyrimidin-2-yl)ethan-1-amine	100	1.3g
  395	tert-butyl (2-methyl-1-(pyrimidin-2-yl)propyl)carbamate	100	1.0g
  396	cyclohexyl(pyrimidin-2-yl)methanamine	85	3g
  397	2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol	85	1.2g
  398	8-(aminomethyl)-3-benzyl-2-hydroxy-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-4-one	100	0.1g
  399	N-(3-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)ureido)pyrimidin-4-yl)amino)-1-methyl-2,3-dihydro-1H-pyrazol-4-yl)acrylamide	100	0.5g
  400	2-Aminothiazole	100	1.4g
  401	4-(4-cyclohexylpiperazin-1-yl)benzene-1,2-diamine	75	1.1g
  402	4-(4-bromo-3-methoxyphenyl)-1-methyl-1H-pyrazole	100	5.0g
  403	1-(3-bromopyridin-2-yl)piperidine-4-carbohydrazide	100	1.4g
  404	(4-bromophenyl)(3-(hydroxymethyl)cyclopentyl)methanone	100	1.6g
  405	3-(3-bromo-2-methoxyphenyl)-1-methyl-1H-1,2,4-triazole	100	5.5g
  406	7-bromo-3-methylene-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine	100	1.5g
  407	(4-chloro-3-nitrophenyl)dimethylphosphine oxide	100	4.3g
  408	4-bromo-9H-pyrido[3,4-b]indole	84	4.4g
  409	2-((3-amino-4-nitrophenyl)amino)ethan-1-ol	100	3.9g
  410	tert-butyl (1-(3-methylpyridin-2-yl)ethyl)carbamate	100	0.8g
  411	2-nitro-5-(2,2,6-trimethylmorpholino)aniline	100	4.2g
  412	1-(4-amino-5-nitropyridin-2-yl)azetidin-3-ol	100	0.8g
  413	5-(3-bromo-2-methoxyphenyl)-4,5-dihydrooxazole	100	3.7g
  414	2-methoxy-5-nitropyridin-4-amine	100	2.9g
  415	5-(4-chloro-2-fluoro-5-methoxyphenyl)-1-(difluoromethyl)-2-methyl-1,2-dihydro-3H-pyrazol-3-one	100	2.7g
  416	2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenol	100	1.5g
  417	N-(4-(1-methoxyvinyl)phenyl)acrylamide	100	1.2g
  418	8-(trifluoromethyl)quinazolin-4-ol	59	4.7g
  419	ethyl 4-bromothiazole-5-carboxylate	98	3.9g
  420	2-methoxy-4-morpholinobenzoic acid	100	108g
  421	2-carbamoyl-1-(4-chloro-2-methylphenyl)-6-methoxy-1,2,3,4-tetrahydroisoquinolin-7-yl trifluoromethanesulfonate	100	8.1g
  422	3-(trifluoromethyl)benzohydrazide	100	8.9g
  423	N-(4-bromobenzyl)-2,2,2-trifluoroacetamide	100	10.9g
  424	methyl 6-chloro-4-((2-(methylthio)phenyl)amino)nicotinate	100	2.6g
  425	4-iodo-2-methoxynicotinaldehyde	78	9.2g
  426	2-bromo-3,4-dichloro-5-methyl-6-nitroaniline	100	7.3g
  427	4-fluoro-5-morpholinobenzene-1,2-diamine	100	8g
  428	7-chloro-4-(4-methoxybenzyl)-2-methyl-5-oxo-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-b]pyridine-6-carbaldehyde	93.4	102.1g+37.5g
  429	5-bromo-2-methoxy-3-nitrobenzamide	88.5	15.42g
  430	4-(benzyloxy)-2-naphthoic acid	92.79	115.1g+52.4g
  431	4-bromophenol	100	41.4g
  432	7-chloro-2-ethyl-4-(4-methoxybenzyl)-5-oxo-4,5-dihydro-2H-[1,2,3]triazolo[4,5-b]pyridine-6-carbaldehyde	78	161.1g+88.9g
  433	methyl 6-chloro-4-((2-(methylthio)phenyl)amino)nicotinate	100	3.9g
  434	tert-butyl 3-carbamoylazetidine-1-carboxylate	100	7.6g
  435	N-(3-bromobenzyl)-2,2,2-trifluoroacetamide	100	7.5g
  436	5-bromothiazol-2-amine	100	43.8g
  437	5-bromo-4-iodo-2-methoxynicotinaldehyde	91	6.3g
  438	1-(2-chloro-7-(pent-4-en-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propan-1-one	100	15.1g
  439	4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-	99	4.4g
  440	7-nitro-1-tosyl-1H-indole	95	8.5g
  441	methyl 5-methyl-1H-pyrazole-3-carboxylate	100	142.5g
  442	2-(4-hydroxy-3-nitrophenyl)acetic acid	100	27.2g
  443	7-chloro-2-ethyl-4-(4-methoxybenzyl)-5-oxo-4,5-dihydro-2H-pyrazolo[4,3-b]pyridine-6-carbaldehyde	100	3.4g
  444	6-chloro-4-methylpyridazin-3(2H)-one	100	3.6g
  445	N-(3-chloro-4-methoxy-2-nitrophenyl)acetamide	100	3g
  446	2-fluoro-3-morpholino-6-nitroaniline	80.7	10.7g
  447	ethyl 5-morpholinopyrazolo[1,5-a]pyrimidine-3-carboxylate	100	7.4g
  448	4-nitro-1H-indole	93	45.3g
  449	5-(1-methoxyvinyl)-4-nitro-1H-pyrazole	100	28g
  450	tert-butyl (2-methyl-1-(pyridin-2-yl)propyl)carbamate	100	16.9g
  451	5-([1,4'-bipiperidin]-1'-yl)-2-nitroaniline	100	7.9g
  452	tert-butyl (E)-3-(4-morpholinophenyl)acrylate	99	1753mg
  453	2-(5-fluoro-1H-indol-3-yl)-2-oxoacetic acid	99	982mg
  454	2-(7-chloro-1H-indol-3-yl)-2-oxoacetic acid	99	484mg
  455	2-(7-fluoro-1H-indol-3-yl)-2-oxoacetic acid	99	1006mg
  456	2-(5-methoxy-1H-indol-3-yl)-2-oxoacetic acid	99	2001mg
  457	tert-butyl (E)-3-(4-(4-methylpiperazin-1-yl)phenyl)acrylate	99	2187mg
  458	2-(5-methyl-1H-indol-3-yl)-2-oxoacetic acid	99	807mg
  459	2-(7-methyl-1H-indol-3-yl)-2-oxoacetic acid	99	2089mg
  460	2-(6-methoxy-1H-indol-3-yl)-2-oxoacetic acid	99	1877mg
  461	2-(6-methyl-1H-indol-3-yl)-2-oxoacetic acid	99	924mg
  462	2-(5-chloro-1H-indol-3-yl)-2-oxoacetic acid	99	297mg
  463	4-(piperidin-1-yl)benzaldehyde	99	1657mg
  464	4-morpholinobenzaldehyde	99	1786mg
  465	2-(4-methoxy-1H-indol-3-yl)-2-oxoacetic acid	99	2231mg
  466	2-(4-chloro-1H-indol-3-yl)-2-oxoacetic acid	99	1729mg
  467	5-phenyl-3,4-dihydronaphthalen-1(2H)-one	99	103 mg
  468	methyl 6-(benzyloxy)-1H-indole-2-carboxylate	95	121 mg
  469	methyl 3-(4-(cyclohexyloxy)phenethyl)-6-methoxy-1H-indole-2-carboxylate	95	100 mg
  470	1-allyl-3-(cyclohexyloxy)benzene	90	115 mg
  471	methyl 6-phenoxy-1H-indole-2-carboxylate	90	125 mg
  472	methyl 6-(3-((tert-butyldimethylsilyl)oxy)propyl)-1H-indole-2-carboxylate	95	130 mg
  473	3-vinyl-1,1'-biphenyl	99	105 mg
  474	2-(2,6-difluoro-4-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane	90	480 mg
  475	(3,5-difluorophenyl)(methyl)sulfane	90	220 mg
  476	3-(2-bromo-3-methylphenyl)propan-1-ol	90	350 mg
  477	3'-bromo-2-methyl-1,1'-biphenyl	90	587 mg
  478	methyl 3-(2-hydroxyethyl)-6-methyl-1H-indole-2-carboxylate	90	113 mg
  479	1-(benzyloxy)-4-(4-vinylphenoxy)benzene	90	133 mg
  480	1-(4-vinylphenyl)piperidine		125 mg
  481	phenyl(2-vinylphenyl)methanone	95	265 mg
  482	3-(2-(2'-methyl-[1,1'-biphenyl]-3-yl)ethyl)-1H-indole-2-carboxylic acid	98	50 mg
  483	3-(3-fluorophenyl)-1-vinylbenzene	90	131 mg
  484	2-chloro-1-(3-vinylphenyl)benzene	90	153 mg
  485	4-fluoro-1-(3-vinylphenyl)benzene	90	204 mg
  486	4-(phenyloxy)-1-(prop-2-enyl)benzene	90	134 mg
  487	4-{[3-(benzyloxy)phenyl]oxy}benzene-1-carbaldehyde	90	143 mg
  488	phenyl(4-vinylphenyl)methanone	90	118mg
  489	methyl 3-[(1E)-2-[3-(3-fluorophenyl)phenyl]vinyl]-1H-indole-2-carboxylate	90	104mg
  490	methyl 3-[(1E)-2-[3-(2-chlorophenyl)phenyl]vinyl]-1H-indole-2-carboxylate	90	106mg
  491	methyl 3-[(1E)-2-(4-{[3-(benzyloxy)phenyl]oxy}phenyl)vinyl]-1H-indole-2-carboxylate	90	105mg
  492	3-[3-methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propan-1-ol	90	105mg
  493	3-(4-bromo-3-methylphenyl)prop-2-yn-1-ol	90	120mg
  494	3'-methoxy-2,3,4,5-tetrahydro-1,1'-biphenyl	90	101 mg
  495	3-cyclohexylphenol	98	156 mg
  496	4-((3-cyclohexylphenoxy)methyl)benzaldehyde	90	182 mg
  497	3-cyclohexylaniline	93	156mg
  498	ethyl 2-(4-acetylphenyl)acetate	98	186 mg
  499	4-(4-cyclohexylphenoxy)benzaldehyde	96	203 mg
  500	4-(4-fluorophenoxy)benzaldehyde	99	197 mg
  501	methyl (E)-6-(3-((tert-butyldimethylsilyl)oxy)propyl)-3-(2-(2'-methyl-[1,1'-biphenyl]-3-yl)vinyl)-1H-indole-2-carboxylate	95	169 mg
  502	2-bromo-5-phenyl-1,2,3,4-tetrahydronaphthalen-1-ol	97	143 mg
  503	methyl (E)-3-(3-bromostyryl)-1H-indole-2-carboxylate	99	102 mg
  504	methyl (E)-2-azido-3-(4-((3-cyclohexylphenoxy)methyl)phenyl)acrylate	96	118 mg
  505	2-methyl-1-nitro-4-phenoxybenzene	96	243 mg
  506	methyl 3-(2-(2'-methyl-4-(3-((methylsulfonyl)oxy)propyl)-[1,1'-biphenyl]-3-yl)ethyl)-1H-indole-2-carboxylate	90	56 mg
  507	(R)-4-benzyl-3-((S)-2-(3-chloropropyl)pent-4-enoyl)oxazolidin-2-one	90	135 mg
  508	(S)-2-(3-chloropropyl)pent-4-en-1-ol	90	110 mg
  509	5-allyl-1,3-dioxane	90	120 mg
  510	(S)-2-(tetrahydro-2H-pyran-3-yl)acetic acid	90	65 mg
  511	methyl 3-(2-(6-(3-hydroxypropyl)-2'-methyl-[1,1'-biphenyl]-3-yl)ethyl)-1H-indole-2-carboxylate	95	100mg
  512	methyl 6-bromo-3-(2-ethoxy-2-oxoethyl)-1H-indole-2-carboxylate	100	110mg
  513	3'-ethynyl-4-fluoro-2-methyl-1,1'-biphenyl	95	120mg
  514	tert-butyl (4-(4-formylphenoxy)butyl)carbamate	100	110mg
  515	methyl 6-(3-(3-hydroxypropyl)phenoxy)-1H-indole-2-carboxylate	98	140mg
  516	3-(3-hydroxypropyl)phenol	95	120mg
  517	4-(4-phenoxyphenoxy)benzaldehyde	96	110mg
  518	methyl 6-methyl-1H-indole-2-carboxylate	98	100mg
  519	methyl 6-([1,1'-biphenyl]-3-yloxy)-1H-indole-2-carboxylate	100	150mg
  520	4-(3-(3-hydroxypropyl)phenoxy)benzaldehyde	94	150mg
  521	4-((2'-methyl-[1,1'-biphenyl]-4-yl)oxy)benzaldehyde	100	150mg
  522	5-bromo-N-(3-nitrophenyl)pentanamide	95	120mg
  523	1-(3-nitrophenyl)piperidin-2-one	100	100mg
  524	methyl 6-(4-phenoxyphenoxy)-1H-indole-2-carboxylate	100	100mg
  525	3-(carboxymethyl)-7-methyl-1H-indole-2-carboxylic acid	95	100mg
  526	1-(3-aminophenyl)piperidin-2-one	95	200mg
  527	2-([1,1'-biphenyl]-4-yloxy)-4-fluorobenzaldehyde	95	100mg
  528	N-(5-bromo-2,3-dihydro-1H-inden-4-yl)pivalamide	100	100 mg
  529	3-(6-chloro-5-((R)-3-methylmorpholino)pyridazin-3-yl)-8-oxa-3-azabicyclo[3.2.1]octane	95	230 mg
  530	3-(6-chloro-5-(3,3-dimethylmorpholino)pyridazin-3-yl)-8-oxa-3-azabicyclo[3.2.1]octane	96	220 mg
  531	5-(2-fluoropyridin-4-yl)-2,3-dihydro-1H-inden-4-amine	85	372 mg
  532	(R)-4-(7-iodopyrazolo[1,5-a]pyrimidin-5-yl)-3-methylmorpholine	93	100 mg
  533	4-bromo-3,6-dichloropyridazine	99	515 mg
  534	3,6-dichloro-4-(piperidin-1-yl)pyridazine	98	204 mg
  535	3-ethyl 5-methyl 6-bromoimidazo[1,2-a]pyridine-3,5-dicarboxylate	91	151 mg
  536	(1R,5S)-3-(pyrazolo[1,5-a]pyrimidin-5-yl)-8-oxa-3-azabicyclo[3.2.1]octane	96	136 mg
  537	3-ethyl 5-methyl 8-bromoimidazo[1,2-a]pyridine-3,5-dicarboxylate	95	313 mg
  538	N-(2,3-dihydro-1H-inden-4-yl)pivalamide	100	100 mg

Relevant laboratories

• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 

Relevant articles