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Jan 17,2022
What is ADME?
What is ADME? ADME means absorption, distribution, metabolism and excretion of drugs in organisms.
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Oct 21,2021
To What Extent can the Calculation of ADMET of Candidate Drugs be Predicted?
The discovery and development of new drugs is expensive & time-consuming! Whether a candidate can become a medicine is a work that R&D personnel continue to explore! When a molecule has obtained the desired drug effect, the work of preparing the drug begins to spread, and the research work of “absorption-distribution-metabolism-excretion-toxicity” (ie ADMET) is alsoRead more
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Oct 21,2021
How a Pill Accomplishes its Mission in the Body-ADME
Drugs enter the body through the four processes of absorption, distribution, metabolism, and excretion, but the four processes of different administration routes have their own advantages. Today we talk about the most common oral drug absorption and metabolism processes in the digestive tract. After oral administration of the drug in the gastrointestinal tract, it entersRead more
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Oct 12,2021
Caco-2 Cell Model of ADME Model in Vitro
The new drug development stage includes 4 important stages: target determination, model establishment, lead compound discovery, and lead compound optimization. After the target is determined, a biological model such as an in vitro ADME model of a drug should be established, which is mainly used to study drug absorption, distribution, metabolism and drug toxicity, inRead more
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May 07,2021
Analysis of Three Factors Influencing Ames Test
Salmonella reverse mutation test. The Ames test is currently the internationally recognized test of choice for detecting the mutagenicity and carcinogenicity of new drugs. This test uses the nature of the histidine auxotrophic mutant (His-) of Salmonella typhimurium to produce revertives. Preliminary screening of the mutagenicity of chemical substances. The study found that the concentrationRead more
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Mar 23,2021
When ADME and Drug Interaction Studies Need to be Done?
In addition to the need for evidence to prove that the drug is effective, the FDA and other drug regulatory agencies around the world also emphasize that the compounds used for patients are safe. The key elements of a successful IND or equivalent application include a sound pharmacokinetic (PK) profile covering absorption, distribution, metabolism andRead more
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Mar 23,2021
ADME Properties
In the entire process of drug discovery, the optimization of the ADME (absorption, distribution, metabolism and excretion) properties of drug molecules is the most difficult part. The analysis of the properties of ADME plays a key role in the success of drug development. Possible manifestations of poor properties of the candidate drug ADME Increasing theRead more
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Mar 03,2021
How to speed up the pre-clinical research process of new drugs
According to the process of drug research and development, new drug research and development can be divided into two stages: new drug preclinical research and clinical research. The former refers to the sum of all research work before the drug enters the clinical trial, and the latter refers to the research work completed by theRead more
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Oct 14,2020
High-throughput ADME research in the new drug discovery phase
In the past ten years, the cycle of drug discovery and development has become longer and longer, and the cost of testing has increased. In Western countries, it takes 10 to 15 years to develop and market a new compound entity, and it costs more than US$800 million. Of the 10,000 new compound entities, 10Read more
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Jun 18,2020
Toxicokinetics Test Service Company
“ADME” or “Toxicokinetics” is the process of studying the body’s absorption, distribution, metabolism, and excretion of foreign chemicals. Medicilon Drug Safety Evaluation Service>> Toxicokinetic absorption, distribution, metabolism, excretion The toxicokinetics study used repeated doses of the toxicity test dose to study the dynamic changes of drugs in vivo, and obtained pharmacokinetic data. It is usuallyRead more
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Mar 06,2018
What is Preclinical ADME Studies?
ADME studies–ADME is an abbreviation in pharmacokinetics and pharmacology, stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical andRead more
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Sep 07,2017
ADME Pharmacokinetics Studies
Absorption, Distribution, Metabolism and Excretion • Absorption ‐ Route of Drug Delivery – Where absorbed? • Distribution ‐ Where does the drug go, where does it need to go and what are the implications?• Metabolism Metabolism ‐ This will occur and could impact several several variables variables. – Could be used to your advantage ‐Read more
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Sep 06,2017
High Throughput ADME Study of New Drug Discovery
For the development of innovative drugs, the process consists of three stages and four steps: target discovery, characterization and evaluation (biological target phase); Discovery and optimization of lead compounds (drug discovery phase); ADMET (absorption, distribution, metabolism, excretion and toxicity), PK, PD studies (drug discovery and development phase); clinical trial (drug development stage). High Throughput ADMERead more
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Aug 25,2017
Influential Factors for Pharmacokinetic Study
Pharmacokinetic is a quantitative study of drugs in the body absorption, distribution, metabolism and excretion of the law, and the use of mathematical principles and methods to explain the plasma concentration with time changes in a discipline. There are four factors that will influence the pharmacokinetic test: water-solubility, fat-soluble, dissociation degree and molecular weight. WaterRead more
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Aug 14,2017
Factors Affecting Pharmacokinetics of Drugs
Factors Affecting ADME. There are four factors that will influence the pharmacokinetic drugs test: water-solubility; fat-soluble; dissociation degree and molecular weight. Pharmacokinetic is a quantitative study of drugs in the body absorption, distribution, metabolism and excretion of the law.  Related Articles: ADME Pharmacokinetics Studies Pharmacokinetics and Pharmacodynamics (PK/PD) Studies Drug Metabolism and Pharmacokinetics (DMPK) StudiesRead more
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Jul 20,2017
Pharmacokinetics and Pharmacodynamics (PK/PD) Studies
Pharmacokinetic / pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affectsRead more
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Sep 28,2016
Drug Metabolism and Pharmacokinetics (DMPK) CRO
DMPK or Drug Metabolism and Pharmacokinetics is a major part of studies related to drugs often referred to as ADME (Absorption, Distribution, Metabolism and Elimination). It is concerned with the study of aspects of absorption, distribution, metabolism and elimination of drug compounds which are administered through any route of administration. Drug Metabolish and Pharmacokinetics areRead more
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Aug 26,2016
Medicilon’s Preclinical Pharmacokinetic Study Services
Pharmacokinetics is the study of the way the body deals with the absorption, distribution, metabolism, and excretion of drugs under investigation expressed in mathematical terms. The effects and the duration of action of the drug are also taken into account. With over 12 years of experience of operating a GLP and non-GLP compliant laboratory, MedicilonRead more
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Aug 24,2016
Medicilon’s Drug ADME/PK Assays Services
Medicilon’s pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and etc.Read more
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Dec 01,2015
Toxicokinetic Testing Service Company
“ADME” means “toxic pharmacokinetics”, which is the study of the body’s absorption, distribution, metabolism and excretion of foreign chemicals. Medicilon Drug Safety Evaluation Service》》 Toxicokinetic absorption, distribution, metabolism, excretion The toxicokinetic study adopts repeated administration toxicity test dose to study the dynamic change law of the drug in the body and obtain pharmacokinetic data. UsuallyRead more
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