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Dextran Sodium Sulfate (DSS) is a synthetic sulfate polysaccharide that can be used as an inflammatory agent to induce colon cancer models in mice. Oral administration of sodium dextran sulfate can directly damage colonic epithelial cells and induce inflammatory reactions by destroying the partition of commensal bacteria in the intestine. Colon cancer is a relativelyRead more

Cervical cancer is a disease that seriously threatens women’s lives and health. The establishment of a mouse cervical cancer model can provide an experimental model for the research and development of new drugs and individualized treatments for cervical cancer. Human cervical squamous cell carcinoma SiHa cells are a kind of cells that can be usedRead more

Medicilon provides various effective animal models according to customer needs to test the effectiveness of drugs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, and guinea pigs. At present, we have established a number of effective animal models, and have passed multiple verifications and long-term practical tests. At the same time, our employees’ richRead more

After years of experience accumulation, multi-party verification and long-term practical tests, Medicilon’s Pharmacodynamic Department has established a complete animal model library, which can provide various effective animal models to test the effectiveness of drugs according to customer needs. Laboratory animals include non-human primates, dogs, large mice, rabbits, guinea pigs, minipigs, etc. Tumor modeling techniques includeRead more

1) Research on animal tumor transplantation model level In the initial screening or evaluation of the effectiveness of anti-tumor drugs, the mouse tumor transplantation model was used for in vivo tests. Animal tumor transplantation models often use Kunming or purebred mice to inoculate mouse tumors to observe the inhibitory effect of the test substance onRead more

BALB/c mice BALB/c mice Features and uses: ◇ Its incidence is low, but it is sensitive to carcinogens. The incidence of breast tumors is about 10﹪~20﹪. ◇ There are a certain number of ovarian, adrenal and lung tumors, which are extremely sensitive to radiation. You are susceptible to chronic pneumonia.  ◇Most individuals develop immunoglobulin syndromeRead more

Through research on gut inflammation, researchers have found that probiotics are not always ‘good bacteria’, and may not be good for everyone. Studies using a novel human “gut-inflammation-on-a-chip” suggest that probiotic bacteria may not always be a benefit to our health. Woojung Shin, Ph.D. student, and Hyun Jun Kim, Ph.D., assistant professor in the departmentRead more

Parkinson’s disease (PD) is a neurodegenerative disorder that is marked by the accumulation of the protein, α-synuclein (αS), into clumps known as Lewy bodies, which diminish neural health. Now, researchers from Brigham and Women’s Hospital (BWH) report the development of a mouse model to induce PD-like αS aggregation, leading to resting tremor and abnormal movement control.Read more

A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai.  The data garnered through thisRead more

Alzheimer’s disease is the most common form of dementia.  It affects around 5.7 million people in US – and this number is predicted to rise.  Some estimate that, by 2050, 13.8 million US adults might be affected.  Despite its growing prevalence, treatment options are lacking and there is no cure. The exact causes are notRead more