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This year, Medicilon, with persistent belief, courageously and innovatively, pursued quality, and gave birth to the power of joint growth. Today, we take you to review the 2021 and witness the growth and progress of Medicilon!

Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.

Medicilon boasts nearly 300 in vivo tumor models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology.

In animal tumor transplantation models, Kunming mice or purebred mice are often used to inoc-ulate mouse tumors, and the inhibitory effect of the test substance on tumor growth is observed.

Nude mice are immunodeficient animals because they have no thymus glands, so they lack immune response. Medicilon Pharmacology Service provides you with experiments on tumor formation in nude mice and subcutaneous tumor formation in nude mice.

The skin is composed of two parts, the epidermis and the dermis, which are connected to the deep tissue by the subcutaneous tissue. Today, I will give you a brief introduction to the animal model of skin disease of solar dermatitis and psoriasis.

What is Animal Disease Models? Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.

For those drugs with low metabolic rate, high toxicity, or lack of sensitive detection methods, in vitro drug metabolism studies can eliminate the interference of internal factors and provide reliable theoretical data for the overall experiment. The liver microsomal model is one of the common in vitro models for studying drug metabolism in laboratories. ItRead more

The syngeneic tumor mouse model is one of the earliest tumor animal models, and it has a history of at least 50 years. This type of model is to transplant tumor cells or tissues derived from mice into host mice with the same genetic background and immune capabilities. The allograft (ie, tumor) formed in theRead more

Before the sponsor submits the IND application, the sponsor can request a Pre-IND meeting FDA with the review leader. The main purpose of the meeting is to evaluate and reach consensus on the design of animal research needed to support the first human trial, which can speed up the development of new drugs, effectively shortenRead more

Medicilon is a company engaged in pre-clinical research services (CRO), which specializes in providing customers with customizable pre-clinical trial service programs. Professional knowledge in pharmacodynamic research and toxicology. Provide you with high-quality data and fast turnaround to support various drug development, preclinical research and clinical research. Help you select the most valuable drug candidates intoRead more

In the consistency evaluation of generic drugs, it is very important to take effective measures to accurately evaluate the in vivo and in vitro relevance of drugs. Appropriate in vivo and in vitro correlation models can accurately predict the action characteristics of the drug in vivo, thereby guiding and optimizing the formulation design, establishing moreRead more

Good Laboratory Practice(GLP) is related to drug registration. It is a regulatory document that non-clinical trials used to evaluate drug safety need to comply with. Many new drugs entered the clinic after simple animal experiments showed that they had certain effects and were not very toxic. At the same time, the clinical trial was tooRead more

GLP, non-clinical quality management practices for drugs, is the basic principle that drugs must follow for pre-clinical research. At present, the distance between my country’s GLP organization, China GLP, and developed countries such as the United States, has gradually narrowed, and the organization that ranks first in China’s GLP organization also affirms the strength ofRead more

Animal experiment facilities refer to the sum of buildings, equipment, and operation management for the purpose of research, experimentation, teaching, biological products and pharmaceutical production, etc., for the breeding and experimentation of experimental animals. Its management is very important for applying for GLP certification. Companies that rank high in China’s GLP organization will undoubtedly payRead more

The preclinical stage includes the discovery and optimization of lead compounds, the establishment of targets and models. Both can be used as the starting point for drug development: 1. Lead compounds are obtained through screening models, the lead compounds are optimized, and then the model is used for evaluation; 2. Medicinal chemistry can also beRead more

With the continuous improvement of biological science and technology, the current models constructed using model organisms are playing an increasingly important role in drug screening. Patients with depression and anxiety often have lower levels of serotonin in their bodies. For these patients, some drugs that increase serotonin levels are often used clinically. Serotonin, also knownRead more

Epstein-Barr virus (EBV) is a herpes virus that is pathogenic to humans. It has been found to be associated with nasopharyngeal cancer, some gastric cancer, laryngeal cancer and Hodgkin’s lymphoma. Although the proportion of EB virus directly causing cancer is very low, because of the high proportion of human infections, the eradication of cancer causedRead more

Practical methods for evaluating tumor cell growth and survival are very important in tumor research.In preclinical efficacy evaluation of antitumor drugs, in vitro MTT pharmacodynamics experiments are often used to explore the inhibitory effect of compounds on the growth of tumor cells in vitro, or in vivo tumor transplantation pharmacodynamics experiments are used to exploreRead more

In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more