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Medicilon boasts nearly 300 in vivo tumor models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology.

What is an API Drugs? API drugs refer to the raw materials used in the production of various preparations. They are the effective ingredients in the preparations. Various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction or biotechnology, are used for medicinal purposes. Substances taken directly. APIs, also known as active ingredients ofRead more

Genuine Drug-What is a Genuine Drug? Genuine medicine is a concept unique to China, and it is called original research drug in European and American countries. It refers to the original research and development of new drugs, which have been approved for listing after tens of thousands of compounds and rigorous clinical trials. It takesRead more

The particle size of the API, as a key material attribute in the development of formulations, not only affects the powder properties of the API (such as fluidity), the uniformity of the formulation content, the chemical stability of the API and the formulation, but also affects the dissolution of the formulation, which in turn affectsRead more

The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more

Intermediates refer to intermediate products in the process of compound synthesis. Pharmaceutical intermediates are some chemical APIs or chemical products used in the synthesis process of APIs. They do not require a production license for APIs and can be produced in ordinary chemical plants. , As long as it reaches a certain level, it canRead more

APIs are the prerequisite for the production of pharmaceutical preparations. In all links of the pharmaceutical industry chain, they play the role of processing and manufacturing basic pharmaceutical industry APIs, and most of them are outsourced production. API drug outsourcing process services refer to pharmaceutical companies entrusting other pharmaceutical R&D institutions to conduct API outsourcingRead more

Residual solvents in drugs are defined in Q3C as organic volatile compounds produced or used in the production of bulk drugs or excipients, and during the preparation of the formulations, and they cannot be completely eliminated in the process. In the process of drug substance impurity analysis, the study of residual solvents has attracted muchRead more

Pharmaceutical preparations are composed of three major elements: qualified raw materials, appropriate amounts of excipients, and scientific production technology. Among them, the quality of raw materials is the first element that affects pharmaceutical preparations. Pharmaceutical outsourcing process institutions can provide outsourcing process R&D and production of intermediates, bulk drugs, preparations, etc. Starting materials are anRead more

Compared with the production of pharmaceutical preparations, the production process of API drugs has its own characteristics. Because the production process of APIs often includes complex chemical and biological changes, and has a relatively complex intermediate control process, by-products are often produced during the production process, which usually requires a purification process. At present, manyRead more

The preparation and research of APIs is at a critical position in the chemical drug R&D process, and the structure of the prepared compounds is consistent to ensure that subsequent quality control studies, pharmacology and toxicology studies, and clinical studies are meaningful. Through the structure of the synthesized APIs Confirmation can characterize whether the structureRead more

With the development and progress of antibody technology, the research and development of double antibodies has shown a good development prospect, which is expected to fill the shortcomings of current therapies in some indications. Recently, Medicilon assisted Biotech’s first double antibody (PD-L1/CD47). ) Apply for clinical application. With the development of bi-antibody technology, bi-antibody nowRead more

In the development of pharmaceutical preparations, due to the different synthesis processes of API from different sources, there may be differences in their solubility, crystal form, particle size, and impurities, which may affect the consistency of the product. In the evaluation of the consistency of generic drugs, the particle size control of API should notRead more

Cell therapy Cell therapy is the introduction of new cells into a tissue to stimulate the body’s ability to heal itself and repair or rebuild a strong immune system in order to treat disease. Cell therapy is mainly divided into stem cell therapy and immune cell therapy. Stem cells therapy Stem cells have the abilityRead more

The stability of a drug substance or preparation refers to its ability to maintain physical, chemical, biological and microbiological properties. Stability research is based on the systematic research and understanding of APIs or preparations and their production processes. The quality characteristics of APIs or preparations obtained through design tests will vary under the influence ofRead more

With the rapid development of molecular biology research, especially the human genome project, many new techniques have emerged in order to adapt to the development trend of functional research on many genes or proteins. Yeast two-hybrid is one of them. Yeast two-hybrid is one of them. So let’s briefly understand what is the yeast two-hybridRead more

(1) Introduction to the pre-clinical CRO industry The pre-clinical research business of our new drug involves pre-clinical compound screening, pre-clinical phase and clinical phase 1, with pre-clinical phase as the main focus. Pre-clinical research refers to conducting laboratory research and live animal research on candidate drugs obtained in the research phase of the compound underRead more

Stability research runs through the entire stage of drug research and development. This article mainly outlines the general principles and precautions in the drug stability research process from the perspectives of new/generic APIs and the stability of new/generic formulations. effect. The origin of the storage conditions of the stability test According to the concept proposedRead more

On March 10, 2021, Cybrexa Therapeutics, Inc., a biotech company focused on oncology, announced the completion of a $25 million Series B funding round to develop novel therapies through its Alphalex ™ Peptide Drug Conjutate (PDC) oncology targeting platform.The financing includes Highcape Capital and new investor Elm Street Ventures.The funds raised will be used toRead more

The purpose of this review is to analyze the structural and functional characteristics of the immune checkpoint CD47, focusing on the preclinical research and clinical trial data of monoclonal antibodies, humanized antibodies and bispecific antibodies targeting CD47, and comprehensively analyzing anti-CD47 Challenges and opportunities for therapies in future clinical applications. Tumor cells bind to signal-regulatedRead more