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Containbioavailability-studiesContent

Jan 17,2022
What is ADME?
What is ADME? ADME means absorption, distribution, metabolism and excretion of drugs in organisms.
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Oct 12,2021
Understand Whether the Structure of the Synthetic API is Correct
The preparation and research of APIs is at a critical position in the chemical drug R&D process, and the structure of the prepared compounds is consistent to ensure that subsequent quality control studies, pharmacology and toxicology studies, and clinical studies are meaningful. Through the structure of the synthesized APIs Confirmation can characterize whether the structureRead more
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Oct 12,2021
Caco-2 Cell Model of ADME Model in Vitro
The new drug development stage includes 4 important stages: target determination, model establishment, lead compound discovery, and lead compound optimization. After the target is determined, a biological model such as an in vitro ADME model of a drug should be established, which is mainly used to study drug absorption, distribution, metabolism and drug toxicity, inRead more
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Sep 29,2021
Integrated Preclinical Trials Services
COMPANY PROFILE Shanghai Medicilon Inc. is one of the top contract research organizations (CRO) in China. Since its establishment in 2004, Medicilon has been striving to offer fully integrated pharmaceutical services for the global scientific community. We have over 1,900 employees cross biology, chemistry and preclinical research. Over 30% of our employees have M.S. andRead more
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Sep 28,2021
Improving Oral Bioavailability of Poorly Water-soluble Drugs
In the past decade, the discovery of poorly soluble drugs has prompted a continuous need to develop a new dosage form to increase the solubility of these drugs. They increase the solubility of the drug in the gastrointestinal tract by increasing the dissolution rate of the drug in the gastrointestinal tract, thereby promoting the absorptionRead more
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Sep 28,2021
Asaron Pharmacokinetics and Bioavailability Test
Asarone is based on a-asarone (2,4,5-trimethoxy-1-alkenylbenzene, also known as a-Asarone), the main active ingredient in the traditional Chinese medicine Acorus calamus. It is artificially synthesized to relieve cough and asthma. Anti-epileptic drugs. Since the blood concentration of the drug after entering the human body is very low, it is difficult to carry out pharmacokinetic studiesRead more
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Sep 28,2021
Bioavailability of Different Dosage Forms of Glimepiride
Glimepiride belongs to the third generation of sulfonylureas and is widely used clinically in the treatment of type 2 diabetes. Tablets and pills are common dosage forms of glimepiride. Using in vitro dissolution tests to determine the bioavailability of glimepiride tablets and dropping pills can evaluate the quality of glimepiride in different dosage forms producedRead more
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Sep 27,2021
The Effect of Particle Size on Drug Bioavailability
Controlling the particle size of a drug is a key part of drug preparation. The size of the drug particle size can directly affect the solubility and dissolution rate of the drug, thereby affecting the clinical efficacy. For example, in the development of solid preparations, reducing the particle size of drug particles can significantly increaseRead more
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Sep 23,2021
Medicilon-Your Ideal DMPK Research Partner
The research and development of innovative drugs is a long-term process with high investment, high risk and high return. It takes more than ten years on average from early discovery to successful listing, and the cost is as high as more than 1 billion US dollars. Pharmacokinetics (DMPK) research runs through all stages of leadRead more
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Sep 15,2021
Study on the Pharmacological Effects of Dendrobium Nobile and its Pharmacokinetics in Rats
Dendrobium nobile has a long history of medicinal use. It is a common traditional Chinese medicine. The chemical components are divided into alkaloids, glycosides, phenanthrene and bibenzyls according to the structure type. Its pharmacological effects are mainly manifested in anti-tumor, hypoglycemic and anti- Nervous system protection and other aspects. The pharmacokinetic study of dendrobine inRead more
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Sep 10,2021
In Vivo and in Vitro Studies of Formulation and Consistency Evaluation of Generic Drugs
In the consistency evaluation of generic drugs, it is very important to take effective measures to accurately evaluate the in vivo and in vitro relevance of drugs. Appropriate in vivo and in vitro correlation models can accurately predict the action characteristics of the drug in vivo, thereby guiding and optimizing the formulation design, establishing moreRead more
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Sep 06,2021
Analysis of the Characteristics of Aerosol and Preformulation Research
Aerosol is a dosage form of medicine. It is a dispersion system composed of fine liquid droplets or solid particles (dispersed inner phase) in air or mixed gas (dispersed outer phase). The dispersed ions are extremely small, and the diameter is from 1 to hundreds of nanometers. , Generally divided into high, medium and lowRead more
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Aug 20,2021
What is IND in New Drug Research?
IND Full English name: Investigational New Drug The FDA new drug review process includes two processes: IND application for new drug clinical trial application and NDA application for new drug application. IND is for clinical trial application, and NDA is for new drug marketing application. Medicilon provide the IND filing for the preclinical services. MedicilonRead more
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Aug 02,2021
Drug Safety Evaluation
Medicilon has a professional team and practical experience in drug safety evaluation, and can provide high-quality data and fast turnaround to support various drug safety evaluation studies. Toxicology studies can be performed in accordance with non-GLP or GLP standards. Our research platform has been rated as the Shanghai R&D public service platform. Medicilon drug safetyRead more
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Jul 28,2021
How small molecule metabolites play important functions
Studies have shown that active metabolites can have an impact on all aspects of omics research (genomics, epigenomics, transcriptomics, and proteomics). Under this framework, metabolites mainly regulate the functions of DNA, RNA and protein through two ways, namely chemical modification and metabolite-macromolecule interactions. Chemical modification of biological macromolecules: Metabolite biological macromolecules play an important drivingRead more
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Jul 23,2021
Pharmaceutical Stability Test
The stability of a drug substance or preparation refers to its ability to maintain physical, chemical, biological and microbiological properties. Stability research is based on the systematic research and understanding of APIs or preparations and their production processes. The quality characteristics of APIs or preparations obtained through design tests will vary under the influence ofRead more
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Jul 07,2021
Selection Principles of Laboratory Animals for Drug Preclinical Research
In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more
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Jul 07,2021
Pre-clinical Trial Program of Stem Cell Preparations
In recent years, the research of stem cell-based cell therapy has developed rapidly at home and abroad.In particular, a number of clinical trials have been initiated in the fields of degenerative diseases, cirrhosis of the liver, diseases of the immune system and graft-versus-host diseases.The clinical application of stem cells is developing rapidly, and the numberRead more
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Apr 28,2021
Research found: RBBP8 gene mutation is a key factor in young women suffering from breast cancer
The human CtIP gene, also known as RBBP8, is located on the long arm 11.2 of chromosome 18 and can encode the CtIP protein. There are many studies on CtIP protein, and the relationship between it and tumor pathogenesis is constantly being recognized. Mutations of CtIP protein can be found in a variety of humanRead more
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Apr 08,2021
Points of Interest in Non-clinical Studies of Metabolites in the Development of Small Molecule Drugs
There may be differences in the metabolic characteristics of small molecule drugs in experimental animal species and humans, and there may be unique or high-level metabolites in humans. If these metabolites are not identified or fully evaluated in non-clinical safety trials, the safety of human medications may not be fully guaranteed. Depending on the specificRead more
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