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Jan 04,2022
Sincere Collaboration, New and Far-Reaching - Bao Pharmaceutical and Medicilon reached a strategic collaboration
On December 17, 2021, Shanghai Bao Pharmaceutical Co., Ltd. (Bao) and Shanghai Medicilon Inc. (Medicilon) signed an innovative drug IND R&D service strategy collaboration agreement.
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Oct 25,2021
Medicilon Symposium – “Preclinical Development Strategy of Innovative Drugs Driven by Translational Medicine” was Successfully Held
The 4th Annual Precision Medicine and Immuno-Oncology China Summit 2021 (PMIO China 2021) was successfully held in Zhangjiang, Shanghai recently.  Shanghai Medicilon Inc. (Medicilon) and
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Jan 04,2022
Recording the Growth of Medicilon in 2021
This year, Medicilon, with persistent belief, courageously and innovatively, pursued quality, and gave birth to the power of joint growth. Today, we take you to review the 2021 and witness the growth and progress of Medicilon!
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Jan 19,2022
Medicilon MPTP Parkinson Disease Model
Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.
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Jan 17,2022
What is ADME?
What is ADME? ADME means absorption, distribution, metabolism and excretion of drugs in organisms.
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Nov 18,2021
Consistency Evaluation of Oral Solid Dosage
As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid dosage forms for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more
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Nov 16,2021
Pre-clinical Research Escorts the Development of Innovative Drugs
The first challenge in drug development is the pre-clinical research of new drugs, which refers to the chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics, and toxicology that are carried out before the drug enters clinical research. And pharmaceutics research. Preclinical research on new drugs escorts the development of innovative drugs.Read more
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Nov 12,2021
Non-labeled Natural Product Target Identification and Validation
The structure of natural products is complex and rich, with a wide range of biological activities, and is an important source of new drug innovation. According to statistics, nearly half of the drugs approved by the U.S. Food and Drug Administration (FDA) for cancer treatment in the past 30 years Medicines are directly or indirectlyRead more
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Nov 11,2021
Preparation Method and Related Synthesis Process of Chiral Drug
Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more
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Nov 11,2021
Chiral Drug Synthesis
Chiral drugs refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the “Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, theRead more
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Nov 08,2021
Top 10 Global Clinical Research Organizations in 2021
In 2020, a global outbreak of the new crown epidemic disrupted the business activities of almost all companies, and the drug R&D and production of pharmaceutical companies was no exception. As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market order is chaotic.    2021Read more
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Nov 05,2021
Drug Local Toxicity Test
Local toxicity refers to the damaging effects of certain drugs directly caused by the contact parts of the body. It initially manifests as cell death at the site of direct contact. Mainly include irritation test, allergy test, hemolysis test. Irritation test: Irritation refers to the reversible inflammatory reaction to the administration site after the administrationRead more
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Oct 29,2021
Factors Affecting Metabolism
Metabolism is the process of changing the chemical structure of drugs in the human body. The main organ that can metabolize drugs in the human body is the liver, followed by the small intestine, kidney, lung, and brain tissue. For more details, please read Factors Affecting Pharmacokinetics of Drugs. Factors Affecting Drug Metabolism: Genetic factors:Read more
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Oct 28,2021
Factors Affecting Drug Metabolism
Drug metabolism refers to the chemical change process of drugs in the body. Most drugs lose their activity after being metabolized, and are converted into extremely high water-soluble metabolites, which are beneficial to excretion from the body. There are also some drugs that are hardly metabolized in the body and are excreted as original drugs.Read more
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Oct 22,2021
What is an API Drugs?
What is an API Drugs? API drugs refer to the raw materials used in the production of various preparations. They are the effective ingredients in the preparations. Various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction or biotechnology, are used for medicinal purposes. Substances taken directly. APIs, also known as active ingredients ofRead more
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Oct 22,2021
What is the Difference Between Genuine Drugs, Generic Drugs, and APIs?
Genuine Drug-What is a Genuine Drug? Genuine medicine is a concept unique to China, and it is called original research drug in European and American countries. It refers to the original research and development of new drugs, which have been approved for listing after tens of thousands of compounds and rigorous clinical trials. It takesRead more
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Oct 21,2021
To What Extent can the Calculation of ADMET of Candidate Drugs be Predicted?
The discovery and development of new drugs is expensive & time-consuming! Whether a candidate can become a medicine is a work that R&D personnel continue to explore! When a molecule has obtained the desired drug effect, the work of preparing the drug begins to spread, and the research work of “absorption-distribution-metabolism-excretion-toxicity” (ie ADMET) is alsoRead more
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Oct 21,2021
How a Pill Accomplishes its Mission in the Body-ADME
Drugs enter the body through the four processes of absorption, distribution, metabolism, and excretion, but the four processes of different administration routes have their own advantages. Today we talk about the most common oral drug absorption and metabolism processes in the digestive tract. After oral administration of the drug in the gastrointestinal tract, it entersRead more
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Oct 14,2021
What are the DMPK Parameters?
DMPK Parameters: Peak drug concentration (Cmax) The highest blood drug concentration after administration. This parameter is an important indicator reflecting the absorption rate and degree of absorption of drugs in the body.Peak time (Tmax)    the time required to reach the peak concentration of the drug after administration. This parameter reflects the rate at which theRead more
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Oct 13,2021
What are APIs, Original Research Drugs and Generic Drugs?
The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more
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