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Nov 24,2021
Two Innovative Service Platforms of Medicilon were Selected as
Recently, the “2021 Yangpu Service Trade Digital Transformation Forum” under the guidance of the Shanghai Municipal Commission of Commerce and the People’s Government of Yangpu
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Nov 26,2021
FDA Launches Online Center for Biocompatibility Testing
Recently, the FDA launched the Medical Device Biocompatibility Evaluation Resource Center, an online system designed to help users better understand and complete the biocompatibility evaluation of medical devices. This system is not intended to replace the international standard ISO 10993-1 “Biological evaluation of medical devices-Part 1: Evaluation and testing within a risk management process,”, butRead more
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Nov 19,2021
Injection vs. Oral Solid Dosage
From the perspective of various stages, there are big differences between domestic generic drug injections and oral solid dosages in terms of generic drug consistency evaluation, competition pattern, and overall market size. Domestic sales of injections account for too much From the PDB sample data, injections account for more than 60% of domestic prescription drugRead more
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Nov 18,2021
Consistency Evaluation of Oral Solid Dosage
As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid dosage forms for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more
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Sep 24,2021
Acute Toxicity Test/Detection/Evaluation
Acute Toxicity Test / Repeated Dosing Screening Test Acute toxicity evaluation is one of the basic types of in vivo safety evaluation. Drug registration often requires acute toxicity evaluation. Acute toxicity test data has a special role in safety evaluation, and MTD or MFD can be determined in the initial toxicity description. The data obtainedRead more
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Sep 23,2021
hERG and its Evaluation in Drug Development
Drug safety evaluation plays an extremely important role in the drug development process. As some non-cardiovascular drugs have been found to induce acquired QT prolonged syndrome (LQTS), leading to severe arrhythmia (Torsade de Pointes) , TdP) and after withdrawing from the market, the safety evaluation of the drug on the heart becomes extremely important. TheRead more
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Sep 18,2021
Preclinical Research Company
Medicilon is a company engaged in pre-clinical research services (CRO), which specializes in providing customers with customizable pre-clinical trial service programs. Professional knowledge in pharmacodynamic research and toxicology. Provide you with high-quality data and fast turnaround to support various drug development, preclinical research and clinical research. Help you select the most valuable drug candidates intoRead more
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Sep 10,2021
Two Breast Cancer Endocrine Therapy Drugs have Passed the Consistency Evaluation
Breast cancer is a hormone-dependent tumor. Studies have found that for breast cancer patients who are hormone receptor-positive and cannot tolerate surgical treatment, endocrine therapy has found better results. The two commonly used breast cancer endocrine therapy drugs, tamoxifen citrate tablets and anastrozole tablets, have both passed the consistency evaluation of the quality and efficacyRead more
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Sep 10,2021
The Consistency Evaluation of Generic Drugs Requires Attention to the Particle Size of API
In the development of pharmaceutical preparations, due to the different synthesis processes of API from different sources, there may be differences in their solubility, crystal form, particle size, and impurities, which may affect the consistency of the product. In the evaluation of the consistency of generic drugs, the particle size control of API should notRead more
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Sep 10,2021
In Vivo and in Vitro Studies of Formulation and Consistency Evaluation of Generic Drugs
In the consistency evaluation of generic drugs, it is very important to take effective measures to accurately evaluate the in vivo and in vitro relevance of drugs. Appropriate in vivo and in vitro correlation models can accurately predict the action characteristics of the drug in vivo, thereby guiding and optimizing the formulation design, establishing moreRead more
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Sep 08,2021
Feeding and management of animals in GLP lab
GLP, non-clinical quality management practices for drugs, is the basic principle that drugs must follow for pre-clinical research. At present, the distance between my country’s GLP organization, China GLP, and developed countries such as the United States, has gradually narrowed, and the organization that ranks first in China’s GLP organization also affirms the strength ofRead more
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Sep 07,2021
GLP requirements for animal lab environment and facilities
Animal experiment facilities refer to the sum of buildings, equipment, and operation management for the purpose of research, experimentation, teaching, biological products and pharmaceutical production, etc., for the breeding and experimentation of experimental animals. Its management is very important for applying for GLP certification. Companies that rank high in China’s GLP organization will undoubtedly payRead more
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Sep 07,2021
Why should GLP regulations be implemented in new drug research?
GLP, Good Laboratory Practice, is a standard for safety evaluation experiments conducted on medicines, pesticides, food additives, cosmetics, etc., involving all aspects of laboratory work. For drug development, the implementation of GLP in pharmacology and toxicology research can guarantee the reliability, completeness and repeatability of experimental results. The top institutions in the ranking of ChineseRead more
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Aug 23,2021
Preclinical Toxicological Safety Evaluation of Biological Drugs
Toxicology Safety Evaluation of Biological Drugs Biological drugs is one of the fastest-growing sub-sectors in the pharmaceutical industry in recent years. From the global drug sales rankings in the past few years, it can be seen that the proportion of biopharmaceuticals among the top 10 drugs sold has increased year by year. In 2017, seven of theseRead more
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Aug 19,2021
How to do a good job of biological analysis of peptide drugs?
Since Robert Bruce Merrifield synthesized the first biologically active peptide in 1953, research on peptide drugs has developed rapidly, and research on peptide drugs targeting multiple receptors has even been carried out internationally. The maturity of peptide synthesis technology has further accelerated the development of peptide drugs and has become one of the international researchRead more
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Aug 02,2021
Drug cardiotoxicity research technique
Cardiotoxicity caused by some drugs during use is one of the life-threatening toxic side effects of patients. For example, adverse cardiac events caused by antiarrhythmic drugs have been reported from time to time. Although the incidence of such events is low, the risk is high, and the main manifestations are To prolong the QT intervalRead more
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Aug 02,2021
Drug Safety Evaluation
Medicilon has a professional team and practical experience in drug safety evaluation, and can provide high-quality data and fast turnaround to support various drug safety evaluation studies. Toxicology studies can be performed in accordance with non-GLP or GLP standards. Our research platform has been rated as the Shanghai R&D public service platform. Medicilon drug safetyRead more
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Jul 23,2021
Drug development preclinical stage process
Whether it is new chemical entities (NCEs) representing small molecule compound drugs or new molecular entities (NMEs) or new biological entities (NBEs) representing biomacromolecule drugs, the basic criteria for evaluating drugs are safe, effective, and controllable. The research and development and production of drugs not only involve a series of internal issues such as complexRead more
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Jul 13,2021
The role of in vitro MTT experiment in preclinical efficacy evaluation of anticancer drugs
Practical methods for evaluating tumor cell growth and survival are very important in tumor research.In preclinical efficacy evaluation of antitumor drugs, in vitro MTT pharmacodynamics experiments are often used to explore the inhibitory effect of compounds on the growth of tumor cells in vitro, or in vivo tumor transplantation pharmacodynamics experiments are used to exploreRead more
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Jul 07,2021
Selection Principles of Laboratory Animals for Drug Preclinical Research
In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more
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