|
|
CN
Online Message×
Click switch

ContaincroContent

Oct 25,2021
Medicilon was Awarded The “Golden Horse Award-2021 Best Preclinical CRO/CDMO Enterprise”
From October 19-21, 2021, a grand event that has attracted the attention of the national pharmaceutical industry, “2021 Nanjing International Summit on Innovation and Investment
More
Jan 21,2022
Indirect Fluorescent Antibody Test
Indirect Fluorescent Antibody is to use a specific antibody to react with the corresponding antigen in the specimen, and then use a fluorescein-labeled secondary antibody (anti-antibody) to bind to the primary antibody in the antigen-antibody complex, and observe the specificity under a fluorescence microscope after washing.
More
Jan 10,2022
Largest CROs in the World in 2021
As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market is chaotic. This article briefly introduces the top 10 CRO companies in the world.
More
Jan 10,2022
Clinical Research Organization Ranking
The Clinical Research Organization (CRO) helps pharmaceutical manufacturers improve efficiency and speed throughout the clinical trial process. CRO is a service organization that supports pharmaceutical and biotechnology companies in the form of outsourcing drug research services (drugs and medical devices).
More
Nov 24,2021
Disadvantages of Indirect ELISA
Enzyme linked immunosorbent assay (ELISA) refers to the binding of antigen or antibody to the surface of a solid-phase carrier and maintain its immunological activity. The antigen or antibody is linked with a certain enzyme to form an enzyme-labeled antigen or antibody. This enzyme-labeled antigen or antibody retains its immune activity and enzyme activity. CommonRead more
More
Nov 16,2021
Liver Microsome Model of Drug Metabolism Model in Vitro
For those drugs with low metabolic rate, high toxicity, or lack of sensitive detection methods, in vitro drug metabolism studies can eliminate the interference of internal factors and provide reliable theoretical data for the overall experiment. The liver microsomal model is one of the common in vitro models for studying drug metabolism in laboratories. ItRead more
More
Nov 08,2021
Two Leading CRO Organizaitons in America in 2020
Business Structure Comparison LabCorp and IQVIA are the world’s leading CRO organizaitons, and these two organizaitons have been catching up with you. LabCorp is mainly composed of two major businesses, LabCorp Diagnostics (LCD) and Covance Drug Development (CDD), and CDD is composed of Covance Inc., which was acquired in 2015, and is also the leaderRead more
More
Nov 08,2021
Top 10 Global Clinical Research Organizations in 2021
In 2020, a global outbreak of the new crown epidemic disrupted the business activities of almost all companies, and the drug R&D and production of pharmaceutical companies was no exception. As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market order is chaotic.    2021Read more
More
Oct 26,2021
Comparison of E. coli and Insect Baculovirus Expression Systems
Principle of Escherichia coli Expression System The Escherichia coli expression system is an expression system that efficiently expresses genes encoding protective antigens of pathogenic microorganisms in Escherichia coli through DNA recombination technology. It is currently the most commonly used system for recombinant protein expression. The E. coli expression system has been studied earlier and hasRead more
More
Sep 29,2021
Integrated Preclinical Trials Services
COMPANY PROFILE Shanghai Medicilon Inc. is one of the top contract research organizations (CRO) in China. Since its establishment in 2004, Medicilon has been striving to offer fully integrated pharmaceutical services for the global scientific community. We have over 1,900 employees cross biology, chemistry and preclinical research. Over 30% of our employees have M.S. andRead more
More
Sep 27,2021
The Effect of Particle Size on Drug Bioavailability
Controlling the particle size of a drug is a key part of drug preparation. The size of the drug particle size can directly affect the solubility and dissolution rate of the drug, thereby affecting the clinical efficacy. For example, in the development of solid preparations, reducing the particle size of drug particles can significantly increaseRead more
More
Sep 22,2021
Medicilon is Listed on the “Top Chinese R&D CRO Enterprises in 2021”
On the September 18th to 19th, the Smart China Expo’s important series of events, “2021 Conference on High Quality Development of Healthcare Industry and the
More
Sep 18,2021
New Drug Preclinical Trials
"Administrative Measures for Drug Registration" (Bureau Order No. 28) for pre-clinical provisions Article 21 Pre-clinical trail of drugs for the purpose of applying for drug registration, including drug synthesis technology, extraction methods, physical and chemical properties and purity, dosage form selection, prescription screening, preparation technology, inspection methods, quality indicators, stability, pharmacology , Toxicology, Animal pharmacokineticsRead more
More
Sep 06,2021
The Pharmacological Effects of Imperatorin and its Preformulation Study
The pharmacological studies of imperatorin extracted from the dried root of the Umbelliferae plant Angelica dahurica have various effects such as antibacterial, anti-asthmatic, anti-allergic, dilation of blood vessels, and inhibition of tumor cell proliferation. Lipid microspheres and liposomes are drug carriers prepared from natural lipid materials such as phospholipids and cholesterol. With this carrier, drugsRead more
More
Jul 28,2021
How small molecule metabolites play important functions
Studies have shown that active metabolites can have an impact on all aspects of omics research (genomics, epigenomics, transcriptomics, and proteomics). Under this framework, metabolites mainly regulate the functions of DNA, RNA and protein through two ways, namely chemical modification and metabolite-macromolecule interactions. Chemical modification of biological macromolecules: Metabolite biological macromolecules play an important drivingRead more
More
Jul 23,2021
Pharmaceutical Stability Test
The stability of a drug substance or preparation refers to its ability to maintain physical, chemical, biological and microbiological properties. Stability research is based on the systematic research and understanding of APIs or preparations and their production processes. The quality characteristics of APIs or preparations obtained through design tests will vary under the influence ofRead more
More
Apr 12,2021
Summary of preclinical and clinical research progress of anti-tumor antibodies targeting CD47
The CD47 antibody out-license deal reached by Tianjing Bio and Abbvie this week, which reached nearly 2 billion US dollars, once again proved the superstar status of CD47 antibody. Recently, this article titled “Preclinical and Clinical Development of Therapeutic Antibodies Targeting Functions of CD47 in the Tumor Microenvironment” was published by Antibody Therapeutics, a journalRead more
More
Apr 09,2021
Pre-clinical CRO industry analysis
(1) Introduction to the pre-clinical CRO industry The pre-clinical research business of our new drug involves pre-clinical compound screening, pre-clinical phase and clinical phase 1, with pre-clinical phase as the main focus. Pre-clinical research refers to conducting laboratory research and live animal research on candidate drugs obtained in the research phase of the compound underRead more
More
Mar 02,2021
Preclinical CRO-The safety evaluation is the main sector
The safety evaluation is the main sector, and the certification qualification and the area of ​​the laboratory are hard indicators Pre-clinical research services include safety evaluation research, pharmacokinetics, pharmacology and toxicology, animal models, etc. This stage is mainly to conduct laboratory research and live animal research on lead compounds under laboratory conditions to observe theirRead more
More
Mar 01,2021
Status and Prospects in Drug Toxicokinetics
As a cross-discipline of pharmacokinetics and toxicology, toxicokinetics has now become an important content of non-clinical drug research and a bridge and tool for advancing preclinical research to clinical research. This article reviews the basic content of domestic toxicokinetic research at this stage, focusing on the guiding principles of toxicokinetic research, precautions in various aspectsRead more
More