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Jan 04,2022
Medicilon Bacterial Endotoxin Testing Solutions
Bacterial Endotoxin Test Procedure Bacterial endotoxin method development (sample volume 3 bottles/batch, one batch) Bacterial endotoxin method verification (sample volume 3 bottles/batch, three batches) Bacterial endotoxin test (sample volume 3 bottles/batch, three batches) Bacterial endotoxin is one of the components of the cell wall of Gram-negative bacteria: LPS Released after the bacteria die Bacterial endotoxinRead more
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Jan 04,2022
Types of Ligand Binding Assays
After ingesting biotechnology drugs, the body will produce different degrees of immune response based on the immunogenicity of the drug. The drug stimulates the body to form specific anti-drug antibodies (ADA) for the immunogenicity of the drug, allergies, autoimmunity and different The pharmacokinetic characteristics of the drug are anti-drug antibody reactions, which can cause variousRead more
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Nov 29,2021
Biacore Analysis of Medicilon
As a high-throughput test system, Biacore 8K can help customers analyze a large number of samples in a short period of time. Biacore™ 8K can complete the screening, affinity and kinetic characterization of small molecule compound drugs and biotherapeutics at the speed you dream of, and provide the high-quality data you expect. As a newRead more
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Oct 18,2021
Mr. Guolin Wang, Director and Secretary of the Board of Medicilon, won another award!
Recently, the selection of 2021 elite board secretaries of the Cai Lian She (CLS) and the Night of Qingdao Board Secretaries were held in Haitian
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Jan 21,2022
Indirect Fluorescent Antibody Test
Indirect Fluorescent Antibody is to use a specific antibody to react with the corresponding antigen in the specimen, and then use a fluorescein-labeled secondary antibody (anti-antibody) to bind to the primary antibody in the antigen-antibody complex, and observe the specificity under a fluorescence microscope after washing.
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Jan 14,2022
Commonly Used Mouse and Nude Mouse Tumor Model
In animal tumor transplantation models, Kunming mice or purebred mice are often used to inoc-ulate mouse tumors, and the inhibitory effect of the test substance on tumor growth is observed.
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Nov 26,2021
FDA Launches Online Center for Biocompatibility Testing
Recently, the FDA launched the Medical Device Biocompatibility Evaluation Resource Center, an online system designed to help users better understand and complete the biocompatibility evaluation of medical devices. This system is not intended to replace the international standard ISO 10993-1 “Biological evaluation of medical devices-Part 1: Evaluation and testing within a risk management process,”, butRead more
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Nov 26,2021
What is a Biocompatibility Test?
Biocompatibility refers to the mutual adaptability between medical materials and the patient’s tissues and physiological systems. The clinical success of medical materials and their safe use are mainly due to their good biocompatibility. Generally, some medical materials will release toxic substances during use, resulting in incompatibility with patients. For the purpose of monitoring biocompatibility, medicalRead more
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Nov 25,2021
Reagent Stability Testing of In Vitro Diagnosis
Stability research is an important content that runs through the entire IVD product development phase and supports the post-market research of IVD products. It is the basis for setting the product validity period. It can be used to judge the rationality of product production technology, formula selection, and packaging material selection. It is also AsRead more
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Nov 24,2021
ELISA Protocol-Elisa Experiment Standard Operating Method
The Elisa experiment has been widely used clinically due to its high sensitivity and good specificity. However, each link in the operation has a greater impact on the detection effect of the experiment. If you are not careful, it may lead to incomplete color rendering and patterning. Wait for the result. ELISA Protocol The followingRead more
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Nov 24,2021
Disadvantages of Indirect ELISA
Enzyme linked immunosorbent assay (ELISA) refers to the binding of antigen or antibody to the surface of a solid-phase carrier and maintain its immunological activity. The antigen or antibody is linked with a certain enzyme to form an enzyme-labeled antigen or antibody. This enzyme-labeled antigen or antibody retains its immune activity and enzyme activity. CommonRead more
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Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Nov 11,2021
Preparation Method and Related Synthesis Process of Chiral Drug
Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more
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Nov 05,2021
Drug Local Toxicity Test
Local toxicity refers to the damaging effects of certain drugs directly caused by the contact parts of the body. It initially manifests as cell death at the site of direct contact. Mainly include irritation test, allergy test, hemolysis test. Irritation test: Irritation refers to the reversible inflammatory reaction to the administration site after the administrationRead more
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Nov 04,2021
Influence of Hemolysis on Test Results
Specimen hemolysis is one of the most common interference and influence factors in clinical biochemical examination. Hemolysis leads to inaccurate test results, which cannot objectively reflect the patient’s physical condition at that time. The influence of specimen hemolysis on clinical test results is as follows: 1. Influence on RBC Count and RBC Specific Volume  In hemolysisRead more
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Nov 03,2021
Abnormal Result Caused by Hemolysis of Blood Samples
⑴ Influence on biochemical results: Specimen hemolysis is the most common interference and influencing factor in clinical biochemical tests. Hemolysis has an impact on a considerable part of biochemical testing items. Among them, total bilirubin (TBIL), aspartate aminotransferase (AST), total protein (TP), and albumin (ALB) are significantly increased after hemolysis; significant after hemolysis The itemsRead more
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Nov 03,2021
Influence of Hemolysis on the Analysis of Biological Samples
Hemolysis refers to the rupture of red blood cells and the escape of hemoglobin into plasma or serum, which can occur in vivo and in vitro. The factors affecting hemolysis are also very complicated. After hemolysis of plasma and serum, many physiological components such as hemoglobin, bilirubin, phospholipids, etc. increase significantly. These components may affectRead more
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Nov 03,2021
Hemolysis Test
Hemolysis test: refers to the hemolysis and red blood cell aggregation caused by pharmaceutical preparations. Hemolytic reactions include immune hemolysis and non-immune hemolysis. 1. Prepare 2% Red Blood Cells Baoding rabbits, draw blood from the heart 5 m, add 0.2 ml of anticoagulant EDTA, wash with PBS, centrifuge to remove the white blood cells onRead more
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Nov 03,2021
Common Biological Experiment Testing Items
Biological Test Items Under GLP Regulations: Single and multiple dose toxicity test (rodent)Single and multiple dose toxicity test (non-rodent) Reproductive toxicity test (I, II)Genetic toxicity test (Ames, micronucleus, chromosome aberration) Local toxicity test (allergic, irritation, hemolysis) Immunogenicity/Immune toxicology test Safety pharmacology test Toxicokinetic test Carry out systematic pharmacokinetic studies according to the requirements of theRead more
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Oct 27,2021
Fluorescent Antibody Technique
Immunofluorescence technique (immunofluorescence technique) is also known as fluorescent antibody technique. Founded in the early 1940s, in 1942, Coons et al. reported several times that antibodies were labeled with fluorescein isocyanate. It is a technology established on the basis of immunology, biochemistry and microscopy. Immunofluorescence technology includes fluorescent antibody technology and fluorescent antigen technology, becauseRead more
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