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On December 17, 2021, Shanghai Bao Pharmaceutical Co., Ltd. (Bao) and Shanghai Medicilon Inc. (Medicilon) signed an innovative drug IND R&D service strategy collaboration agreement.

The 4th Annual Precision Medicine and Immuno-Oncology China Summit 2021 (PMIO China 2021) was successfully held in Zhangjiang, Shanghai recently.  Shanghai Medicilon Inc. (Medicilon) and

On December 28, 2021, Hangzhou DAC Biotechnology Co., Ltd. (DAC Biotech) DXC007 project was successfully approved for clinical trials. DXC007 is the fourth ADC drug approved for clinical use by DAC Biotech, and it is also the fourth ADC drug that Shanghai Medicilon Inc. (Medicilon) to help DAC Biotech successfully getting approval.

On December 28, 2021, the new generation of CDK2/4/6 small molecule inhibitor RGT-419B independently developed by Regor Therapeutics Group (Regor) was approved by the U.S. Food and Drug Administration (FDA).

DATE: Sep 28-29, 2022

LOCATION: Frankfurt, Germany (Europe)

This year, Medicilon, with persistent belief, courageously and innovatively, pursued quality, and gave birth to the power of joint growth. Today, we take you to review the 2021 and witness the growth and progress of Medicilon!

Two forum themes, an inaugural meeting of Zhangjiang AI New Drug R&D Alliance Establishment, three keynote speeches, three rounds of roundtable discussion, a gathering of

Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.

What is ADME? ADME means absorption, distribution, metabolism and excretion of drugs in organisms.

DATE: 19-20 Oct, 2021

LOCATION: The exhibition center, ACC, Liverpool

Discovery of Lead Compounds Hit to Lead The discovery of lead compounds is the process of turning the “hits” found in screening into “lead compounds” that can be further optimized. The lead compound may be a selected compound or a series of homologs, or it may be a compound derived from literature. However, for high-throughputRead more

From the perspective of various stages, there are big differences between domestic generic drug injections and oral solid dosages in terms of generic drug consistency evaluation, competition pattern, and overall market size. Domestic sales of injections account for too much From the PDB sample data, injections account for more than 60% of domestic prescription drugRead more

As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid dosage forms for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more

For those drugs with low metabolic rate, high toxicity, or lack of sensitive detection methods, in vitro drug metabolism studies can eliminate the interference of internal factors and provide reliable theoretical data for the overall experiment. The liver microsomal model is one of the common in vitro models for studying drug metabolism in laboratories. ItRead more

Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more

The first challenge in drug development is the pre-clinical research of new drugs, which refers to the chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics, and toxicology that are carried out before the drug enters clinical research. And pharmaceutics research. Preclinical research on new drugs escorts the development of innovative drugs.Read more

The structure of natural products is complex and rich, with a wide range of biological activities, and is an important source of new drug innovation. According to statistics, nearly half of the drugs approved by the U.S. Food and Drug Administration (FDA) for cancer treatment in the past 30 years Medicines are directly or indirectlyRead more

On October 22, 2021, the research group of Academician Hualiang Jiang and Mingyue Zheng from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published an article Drug target inference by mining transcriptional data using a novel graph convolutional network framework on Protein & Cell. Researchers applied the Twin Spectrogram Convolutional Network (SSGCN) toRead more

Since the completion of the Human Genome Project in 2003, researchers have been trying to find molecular targets related to specific phenotypes. Many experimental techniques have been developed for the confirmation of new disease targets and the discovery of lead compounds. In addition, the increase in the number of protein structures and the increase inRead more