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Oct 11,2021
Introduction to Medicilon’s Chemistry and Biology Labs: Preclinical Drug Discovery and Development
https://www.youtube.com/watch?v=_dGe5Lbvkys
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Oct 11,2021
Medicilon’s CMC Services: Process and Formulation
Related Articles: The Value and Importance of Preformulation Research
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Sep 15,2021
The 19th Annual San Diego BioPharma Conference
Agenda 9:00 am Welcome and Opening Remarks Tao Wu, PhD, President, SABPA Yi Liu, PhD, Chair, BioPharmaCommittee, SABPA; CEO, Kumqat Biosciences 9:15 am Floyd Romesberg,
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Aug 10,2021
What are the Methods of Protein Separation and Purification?
The separation and purification of protein is an important part of biochemistry. It is a method of separating and purifying the desired target protein from the mixture using bioengineering technology. There are many protein separation companies. Medicilon is a preclinical drug development company (CRO) that can provide protein separation and purification technology services. There areRead more
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May 14,2021
Safety assessment lab of process chemistry
Safety assessment lab of process chemistry In the research and development process of innovative drugs, the chemical process research of drugs plays a pivotal role. 
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Apr 25,2021
Medicilon Appoints Two Vice Presidents
Shanghai Medicilon Inc. recently assigned Dr. Haifeng Yin as the vice president of process chemistry and formulation study, Dr. Baohong Cao as the vice president
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Mar 19,2021
Analytical chemistry experiment specifications and precautions Experimental water
Analytical chemistry experiments should use pure water, generally distilled water or deionized water. Some experiments require the use of double distilled water or higher specifications of pure water (for example, experiments in electroanalytical chemistry, liquid chromatography, etc.). Pure water is not absolutely free of impurities, but the content of impurities is very small. Note: ItRead more
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Mar 18,2021
The Development Trend of Modern Analytical Chemistry
Factors affecting the stability of traditional Chinese medicine preparations Chemical degradation reactions of drugs: hydrolysis, oxidation, isomerization, polymerization, decarboxylation, etc. Main degradation pathways: hydrolysis and oxidation. Types of drugs that are easily hydrolyzed and easily oxidized (1) Types of easily hydrolyzed drugs ① Ester drugs: Andrographolide; ②Amide drugs: penicillin; ③Glycoside drugs: Cardiac glycosides are easilyRead more
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Feb 22,2021
Direct Immunofluorescence or Indirect Immunofluorescence Detection
Direct and indirect methods are not limited to immunofluorescence, they are also related to other technologies that rely on fluorescent dyes, enzymes or colored particles coupled to antibodies, such as flow cytometry, ELISA, and immunohistochemistry. But these two methods are different. As shown in the table below, both methods have their pros and cons: directRead more
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Dec 17,2020
Analysis on the Application of Enzyme Catalysis Technology in Green Chemistry
Green chemistry technology is an innovation to traditional chemistry. The green development of chemical synthetic drugs puts the protection of the environment first and avoids the discharge of harmful substances into the environment, which brings new challenges to traditional chemistry. At present, biotechnology represented by enzyme catalysts not only has good selectivity, but also hasRead more
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Dec 17,2020
Biocatalysis Technology to Improve Atomic Economy
Atomic economy and the 5 “R” principle are the core content of green chemistry technology. The 5 “R” principle refers to Reduction, Reuse, Recycling, Regeneration and Rejection. Atomic economy refers to the full use of each atom in the reactant, thereby It can make full use of resources and prevent pollution. The use of biocatalysisRead more
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Dec 15,2020
Green Chemistry Technology: Photoredox Reaction
The occurrence of chemical reactions depends on the generation of free radical intermediates. Free radical intermediates are atoms or groups with unpaired electrons formed by the homogenization of covalent bonds. The breaking of covalent bonds in traditional chemical reactions often requires extreme conditions such as high temperature and pressure, or substances with harmful radioactivity toRead more
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Dec 09,2020
The Role of Dynamic Combinatorial Chemistry in the Discovery of Lead Compounds
In the new drug development process, wise selection of lead candidates can reduce the high proportion of drug elimination and the high cost of drug candidates that continue to increase in the development process. Discovery of lead compounds and optimization of lead compounds are critical to medical research and development. The combination of lead compoundRead more
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Nov 23,2020
The details of pathological research determine the success or failure of TCR trials
What is TCR? Tissue Cross-Reactivity is an in vitro test that detects the binding of antibody drugs to epitopes on tissues. The purpose is to confirm the binding of the tested antibody to the epitope of the pharmacodynamic target tissue, and to detect whether the antibody binds to the tissue antigen of the non-target site,Read more
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Oct 19,2020
Medicilon-Phenomenex Chiral Segmentation Joint Laboratory Unveiling Ceremony
Shanghai, China, October 15, 2020-Shanghai Medicilon and Phenomenex reached a strategic agreement to jointly build a chemistry laboratory for chiral interchange and further enhance the
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Oct 14,2020
High-throughput ADME research in the new drug discovery phase
In the past ten years, the cycle of drug discovery and development has become longer and longer, and the cost of testing has increased. In Western countries, it takes 10 to 15 years to develop and market a new compound entity, and it costs more than US$800 million. Of the 10,000 new compound entities, 10Read more
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Jul 13,2020
Chemical FTE Service
Medicilon’s chemical department has comprehensive chemical research capabilities and facilities including medicinal chemistry, synthetic chemistry, process research and analytical support, and professional synthetic technology. It has a good record of project advancement and the generation of preclinical drug candidates. We can quickly complete new drug development projects from compound screening to new drug clinical researchRead more
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Jun 19,2020
Proteomics Technical Service
Medicilon’s proteomics technology service integrates multiple technologies such as biochemistry, cell biology, molecular biology, and mass spectrometry to enable protein identification, differential protein quantitative analysis, complex separation, and protein post-translational modification (eg, phosphorylation) , Glycosylation, ubiquitination, etc.) analysis and proteomics informatics analysis. Proteomics essentially refers to studying the characteristics of proteins at a large scale,Read more
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Jun 18,2020
Bio-Plex suspension chip multiple detection platform
The Bio-Plex suspension chip multiple detection platform can simultaneously detect up to 100 molecules in the same sample. Because of its good reproducibility in data, it is now widely used in immunology and various disease research. Such as cardiovascular disease, biomarker screening of tumor-specific markers, development of drug therapy targets, evaluation of drug treatment effects,Read more
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Jun 17,2020
Medicilon Enzyme Activity Testing Service
The biological department of Shanghai Medicilon has extensive experience in the field of in vitro biology, through enzyme level measurement, cell level measurement, cell biology, biochemistry, in vitro isotope measurement, stable cell line establishment, gene knockout, RNAi and MicroRNA Technology, etc., to provide a complete set of biological services. Medicilon Enzyme Level Determination Service EnzymeRead more
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