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ContainimmunogenicityContent

Aug 19,2021
How to do a good job of biological analysis of peptide drugs?
Since Robert Bruce Merrifield synthesized the first biologically active peptide in 1953, research on peptide drugs has developed rapidly, and research on peptide drugs targeting multiple receptors has even been carried out internationally. The maturity of peptide synthesis technology has further accelerated the development of peptide drugs and has become one of the international researchRead more
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Jul 29,2021
Immunogenicity of biologic agents
Biologics have become a core component of many treatment strategies for rheumatic inflammation. Scientists often consider that immunogenicity is the important limiting factor in the early stages of development of biological agents. However, theoretical guidance is relatively limited and the determination methods for measuring immunogenicity are complex, making the development of past research difficult. ButRead more
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Jul 28,2021
Factors affecting immunogenicity
Heterogeneity: That is, the substance is different from the host’s own components or the body’s immune cells have never been in contact with it. The essence of the immune response is to recognize and reject the foreign body, so the antigen that stimulates the immune response generally needs to be a foreign body. Certain physicalRead more
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Jul 28,2021
Why do biological drugs have to do immunogenicity experiments?
Immunogenicity refers to the ability to stimulate the body’s immune system to cause an immune response. Immunogenicity is one of the characteristics of antigens. It can act on the antigen recognition receptors of T lymphocytes and B lymphocytes to make them proliferate and differentiate, thereby producing immune effect substances, such as specific antibodies and sensitizedRead more
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Mar 02,2021
Preclinical CRO-The safety evaluation is the main sector
The safety evaluation is the main sector, and the certification qualification and the area of ​​the laboratory are hard indicators Pre-clinical research services include safety evaluation research, pharmacokinetics, pharmacology and toxicology, animal models, etc. This stage is mainly to conduct laboratory research and live animal research on lead compounds under laboratory conditions to observe theirRead more
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Feb 18,2021
Humanization of antibody reduces the immunogenicity of antibody drugs
The application of antibodies has a history of hundreds of years. As a disease prevention, diagnosis and treatment agent, antibody drugs have undergone the development of murine antibodies, chimeric antibodies, humanized antibodies and fully humanized antibodies. Because the antibody drug is a kind of foreign protein, it is easy to activate the body’s own immuneRead more
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Feb 18,2021
Analysis on the method of immunogenicity detection of biotechnology drugs
Immunogenicity refers to the nature of drugs that stimulate the body to form specific antibodies or sensitized lymphocytes. In the development of biotechnology drugs, immunogenicity testing is an important task. For patients, immunogenicity will affect the safety and effectiveness of drugs, and even cause life-threatening dangers to patients because of the crossover of anti-drug antibodiesRead more
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Dec 04,2020
Immunogenicity Testing Method of Biotech Drugs
Immunogenicity Testing Immunogenicity refers to the nature of drugs that stimulate the body to form specific antibodies or sensitized lymphocytes. In the development of biotechnology drugs, immunogenicity testing is an important task. For patients, immunogenicity will affect the safety and effectiveness of drugs, and even cause life-threatening dangers to patients because of the crossover ofRead more
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Dec 04,2020
Factors Affecting the Immunogenicity of Biological Drugs
Many biopharmaceuticals are immunogenic in animals. Generally speaking, drugs that show strong immunogenicity to animals are also immunogenic to humans. Therefore, immunogenicity tests are required to evaluate the safety of drugs during the development of biological drugs. . For patients, immunogenicity easily affects the safety and effectiveness of drugs, and even causes new fatal diseasesRead more
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Jun 18,2020
Toxicokinetics Test Service Company
“ADME” or “Toxicokinetics” is the process of studying the body’s absorption, distribution, metabolism, and excretion of foreign chemicals. Medicilon Drug Safety Evaluation Service>> Toxicokinetic absorption, distribution, metabolism, excretion The toxicokinetics study used repeated doses of the toxicity test dose to study the dynamic changes of drugs in vivo, and obtained pharmacokinetic data. It is usuallyRead more
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Jun 12,2020
Medicilon Immunogenicity Test Service
Immunogenicity test Immunogenicity test studies include: antibody titer, time of antibody appearance, number of animals with antibody, dose relationship, dynamic change of antibody titer, neutralizing activity of antibody, change of pharmacodynamics, P, and P toxicity during the same period 1. The activation of complement, the deposition of immune complexes in the liver and kidney, theRead more
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Apr 07,2017
Immunogenicity Testing of Medicilon
Immunogenicity testing is focused on the detection and characterization of anti-drug antibodies (ADAs) and the determination whether these ADAs are neutralizing antibodies(NABs), as NABs may affect the pharmacokinetics (PK) of the drug.  It is clear however that animal studies are not considered relevant to predict immunogenicity in humans. Still, the selection of the mini-pig toRead more
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