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On December 17, 2021, Shanghai Bao Pharmaceutical Co., Ltd. (Bao) and Shanghai Medicilon Inc. (Medicilon) signed an innovative drug IND R&D service strategy collaboration agreement.

Bacterial Endotoxin Test Procedure Bacterial endotoxin method development (sample volume 3 bottles/batch, one batch) Bacterial endotoxin method verification (sample volume 3 bottles/batch, three batches) Bacterial endotoxin test (sample volume 3 bottles/batch, three batches) Bacterial endotoxin is one of the components of the cell wall of Gram-negative bacteria: LPS Released after the bacteria die Bacterial endotoxinRead more

After ingesting biotechnology drugs, the body will produce different degrees of immune response based on the immunogenicity of the drug. The drug stimulates the body to form specific anti-drug antibodies (ADA) for the immunogenicity of the drug, allergies, autoimmunity and different The pharmacokinetic characteristics of the drug are anti-drug antibody reactions, which can cause variousRead more

From October 19-21, 2021, a grand event that has attracted the attention of the national pharmaceutical industry, “2021 Nanjing International Summit on Innovation and Investment

On December 28, 2021, the new generation of CDK2/4/6 small molecule inhibitor RGT-419B independently developed by Regor Therapeutics Group (Regor) was approved by the U.S. Food and Drug Administration (FDA).

On November 16, the “2021 Jiemian Health Forum” hosted by Shanghai United Media Group and Jiemian News was successfully held.  As a major part of

On the November 12th, the international index compilation company MSCI announced the results of the November quarterly index review.  Shanghai Medicilon Inc. (stock code: 688202.SH)

Two forum themes, an inaugural meeting of Zhangjiang AI New Drug R&D Alliance Establishment, three keynote speeches, three rounds of roundtable discussion, a gathering of

Indirect Fluorescent Antibody is to use a specific antibody to react with the corresponding antigen in the specimen, and then use a fluorescein-labeled secondary antibody (anti-antibody) to bind to the primary antibody in the antigen-antibody complex, and observe the specificity under a fluorescence microscope after washing.

Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.

The Clinical Research Organization (CRO) helps pharmaceutical manufacturers improve efficiency and speed throughout the clinical trial process. CRO is a service organization that supports pharmaceutical and biotechnology companies in the form of outsourcing drug research services (drugs and medical devices).

DATE: 19-20 Oct, 2021

LOCATION: The exhibition center, ACC, Liverpool

Enzyme linked immunosorbent assay (ELISA) refers to the binding of antigen or antibody to the surface of a solid-phase carrier and maintain its immunological activity. The antigen or antibody is linked with a certain enzyme to form an enzyme-labeled antigen or antibody. This enzyme-labeled antigen or antibody retains its immune activity and enzyme activity. CommonRead more

Oral solid dosage usually refer to the general term for the preparation of tablets, capsules, granules, etc., after natural medicines are crushed and extracted. This article will briefly introduce the difficulty of evaluating the consistency of generic drugs and the competitive landscape of oral solid dosage. It is Difficult to Evaluate the Consistency of OralRead more

Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more

Immunofluorescence technique (immunofluorescence technique) is also known as fluorescent antibody technique. Founded in the early 1940s, in 1942, Coons et al. reported several times that antibodies were labeled with fluorescein isocyanate. It is a technology established on the basis of immunology, biochemistry and microscopy. Immunofluorescence technology includes fluorescent antibody technology and fluorescent antigen technology, becauseRead more

Direct Fluorescent Antibody Technology The direct method is the simplest and most basic method of fluorescent antibody technology. It uses the labeled antibody to directly bind to the corresponding antigen (antigen specimen to be tested) to identify the unknown antigen. Advantages: ① Since there are only two factors involved in the reaction, the result judgmentRead more

In the Non-Clinical stage of new drug development, why develop methods with stability indicators? What is the difference between the non-Clinical stage degradation test and the later stage? What precautions need to be considered? Have the difficult problems in method validation trouble you for a long time? Drug Non-clinical Research and Stability Indication Method Non-clinicalRead more

Pharmacokinetics (pharmacokinetics, PK) and pharmacodynamics (pharmacodynamics, PD), in fact, can be described as key research content, the two complement each other and are indispensable. PK refers to the quantitative study of the changes in the in vivo processes such as absorption (A), distribution (Distribution, D), metabolism (Metabolism, M) and excretion (Excretion, E) of drugs inRead more

DMPK Parameters: Peak drug concentration (Cmax) The highest blood drug concentration after administration. This parameter is an important indicator reflecting the absorption rate and degree of absorption of drugs in the body.Peak time (Tmax) 　　 the time required to reach the peak concentration of the drug after administration. This parameter reflects the rate at which theRead more