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Nov 24,2021
Two Innovative Service Platforms of Medicilon were Selected as
Recently, the “2021 Yangpu Service Trade Digital Transformation Forum” under the guidance of the Shanghai Municipal Commission of Commerce and the People’s Government of Yangpu
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Nov 24,2021
Medicilon is Included in the MSCI China Index!
On the November 12th, the international index compilation company MSCI announced the results of the November quarterly index review.  Shanghai Medicilon Inc. (stock code: 688202.SH)
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Oct 12,2021
Join Medicilon at the AAPS 2021 PharmSci 360
Medicilon is looking forward to meeting you at this year’s American Association of Pharmaceutical Scientists (AAPS) annual meeting—“PharmSci 360″. PharmSci 360 is an in-person meeting + virtual
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Jan 17,2022
What is ADME?
What is ADME? ADME means absorption, distribution, metabolism and excretion of drugs in organisms.
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Jan 10,2022
Clinical Research Organization Ranking
The Clinical Research Organization (CRO) helps pharmaceutical manufacturers improve efficiency and speed throughout the clinical trial process. CRO is a service organization that supports pharmaceutical and biotechnology companies in the form of outsourcing drug research services (drugs and medical devices).
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Jan 07,2022
DRUG DISCOVERY 2021: RECONNECT WITH MEDICILON

DATE: 19-20 Oct, 2021

LOCATION: The exhibition center, ACC, Liverpool

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Nov 25,2021
The Failure of LC-MS Bioanalytical Research Method
A successful LC-MS bioanalysis method transfer can increase the confidence of the sender and recipient laboratories. However, because the transfer of LC-MS bioanalysis methods involves preliminary preparation, communication, and acceptance, and the content of each process is numerous, the negligence of individual details during the method transfer may cause the transfer to fail, and theRead more
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Nov 19,2021
Injection vs. Oral Solid Dosage
From the perspective of various stages, there are big differences between domestic generic drug injections and oral solid dosages in terms of generic drug consistency evaluation, competition pattern, and overall market size. Domestic sales of injections account for too much From the PDB sample data, injections account for more than 60% of domestic prescription drugRead more
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Nov 18,2021
Consistency Evaluation of Oral Solid Dosage
As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid dosage forms for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more
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Nov 03,2021
Abnormal Result Caused by Hemolysis of Blood Samples
⑴ Influence on biochemical results: Specimen hemolysis is the most common interference and influencing factor in clinical biochemical tests. Hemolysis has an impact on a considerable part of biochemical testing items. Among them, total bilirubin (TBIL), aspartate aminotransferase (AST), total protein (TP), and albumin (ALB) are significantly increased after hemolysis; significant after hemolysis The itemsRead more
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Nov 03,2021
Common Biological Experiment Testing Items
Biological Test Items Under GLP Regulations: Single and multiple dose toxicity test (rodent)Single and multiple dose toxicity test (non-rodent) Reproductive toxicity test (I, II)Genetic toxicity test (Ames, micronucleus, chromosome aberration) Local toxicity test (allergic, irritation, hemolysis) Immunogenicity/Immune toxicology test Safety pharmacology test Toxicokinetic test Carry out systematic pharmacokinetic studies according to the requirements of theRead more
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Oct 26,2021
Comparison of E. coli and Insect Baculovirus Expression Systems
Principle of Escherichia coli Expression System The Escherichia coli expression system is an expression system that efficiently expresses genes encoding protective antigens of pathogenic microorganisms in Escherichia coli through DNA recombination technology. It is currently the most commonly used system for recombinant protein expression. The E. coli expression system has been studied earlier and hasRead more
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Oct 21,2021
Development and Verification of Analysis Methods for Disposable Systems
The dissolution/precipitate evaluation is an important part of the process-specific verification of filters and disposable systems in the pharmaceutical field to examine the applicability of equipment (including filters and disposable systems) in specific processes. This article describes the development and validation of the dissolution/precipitate analysis method for the verification test of the dissolution/precipitate, and introducesRead more
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Oct 21,2021
HPLC Analysis Method Development and Verification System
Analytical method development The development of analytical methods mainly includes the selection of chromatographic columns, the selection of mobile phases, the selection of detection wavelengths, and the optimization of gradients. At present, HPLC is mostly used in reversed phase, so this article mainly uses reversed phase as an example to explain. Selection of Column TheRead more
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Oct 21,2021
Summary of the Development and Verification of Analytical Methods for Stability Indicators in New Drug Research
In the Non-Clinical stage of new drug development, why develop methods with stability indicators? What is the difference between the non-Clinical stage degradation test and the later stage? What precautions need to be considered? Have the difficult problems in method validation trouble you for a long time? Drug Non-clinical Research and Stability Indication Method Non-clinicalRead more
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Oct 21,2021
To What Extent can the Calculation of ADMET of Candidate Drugs be Predicted?
The discovery and development of new drugs is expensive & time-consuming! Whether a candidate can become a medicine is a work that R&D personnel continue to explore! When a molecule has obtained the desired drug effect, the work of preparing the drug begins to spread, and the research work of “absorption-distribution-metabolism-excretion-toxicity” (ie ADMET) is alsoRead more
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Oct 13,2021
What are APIs, Original Research Drugs and Generic Drugs?
The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more
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Sep 28,2021
Bioavailability of Different Dosage Forms of Glimepiride
Glimepiride belongs to the third generation of sulfonylureas and is widely used clinically in the treatment of type 2 diabetes. Tablets and pills are common dosage forms of glimepiride. Using in vitro dissolution tests to determine the bioavailability of glimepiride tablets and dropping pills can evaluate the quality of glimepiride in different dosage forms producedRead more
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Sep 15,2021
The Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies and Their Application in Disease Treatment
Therapeutic monoclonal antibodies are currently one of the hotspots in the development of new drugs. Compared with traditional small molecule drugs, their pharmacokinetic characteristics and formation mechanisms are very different. A full understanding of these mechanisms and characteristics can effectively guide Screening and development of monoclonal antibody drugs. Monoclonal antibody drugs provide ideal means forRead more
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Sep 02,2021
Factors Influencing the Dissolution of Solid Dosage Forms
In theory, in vivo drug testing is the most important and reliable basis for evaluating drugs. However, in the development of oral solid dosage forms, the method of measuring bioavailability is used to screen and evaluate each new prescription and process, which is time-consuming and costly. money. Although the results of in vivo and inRead more
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