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Jan 19,2022
Medicilon MPTP Parkinson Disease Model
Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.
Jan 11,2022
Nude Mice Animal Model
Nude mice are immunodeficient animals because they have no thymus glands, so they lack immune response. Medicilon Pharmacology Service provides you with experiments on tumor formation in nude mice and subcutaneous tumor formation in nude mice.
Jan 10,2022
Animal Model of Skin Disease
The skin is composed of two parts, the epidermis and the dermis, which are connected to the deep tissue by the subcutaneous tissue. Today, I will give you a brief introduction to the animal model of skin disease of solar dermatitis and psoriasis.
Jan 10,2022
Animal Disease Model
What is Animal Disease Models? Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.
Sep 18,2021
Preclinical Research Company
Medicilon is a company engaged in pre-clinical research services (CRO), which specializes in providing customers with customizable pre-clinical trial service programs. Professional knowledge in pharmacodynamic research and toxicology. Provide you with high-quality data and fast turnaround to support various drug development, preclinical research and clinical research. Help you select the most valuable drug candidates intoRead more
Sep 15,2021
The Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies and Their Application in Disease Treatment
Therapeutic monoclonal antibodies are currently one of the hotspots in the development of new drugs. Compared with traditional small molecule drugs, their pharmacokinetic characteristics and formation mechanisms are very different. A full understanding of these mechanisms and characteristics can effectively guide Screening and development of monoclonal antibody drugs. Monoclonal antibody drugs provide ideal means forRead more
Sep 07,2021
Medicilon assists Chipscreen Biosciences’ CS12192 to be approved by the FDA
On August 28, 2021, the FDA recently approved the CS12192, a new drug clinical trial application for the treatment of Graft Versus Host Disease (GVHD) independently developed by Chipscreen Biosciences (Chipscreen).  Previously, the drug has obtained clinical approval in China. It is worth mentioning that Shanghai Medicilon Inc. (Medicilon) provides comprehensive preclinical research including pharmacokineticsRead more
Sep 06,2021
Analysis of the Characteristics of Aerosol and Preformulation Research
Aerosol is a dosage form of medicine. It is a dispersion system composed of fine liquid droplets or solid particles (dispersed inner phase) in air or mixed gas (dispersed outer phase). The dispersed ions are extremely small, and the diameter is from 1 to hundreds of nanometers. , Generally divided into high, medium and lowRead more
Jul 12,2021
Effect of chemokine ligand 2 on the learning and memory ability of rats
CC chemokine 2 (CCL2), which is generally expressed in white blood cells and rarely expressed in normal nerve tissues, plays an important role in the innate immunity caused by tissue damage and some diseases. Numerous studies have found that CCL2 can damage the learning and memory of rats. In order to study the effect andRead more
Apr 29,2021
Research on using insect cell expression system to express immune-related molecules
Both CD4 molecule and IL-12 are hot molecules in tumor immunotherapy research. Among them, CD4 molecule has important immunological functions, it can participate in the body’s immune response, and the cytokines of the IL-12 family of interleukins play a role in immune regulation. The immune response can be formed by directly inducing the development ofRead more
Apr 09,2021
What are Preclinical Trials?
Preclinical research refers to chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics and toxicology research, and pharmacy research conducted before the drug enters clinical research. Preclinical trials Content Preclinical research of drugs for drug registration, including drug synthesis technology, extraction methods, physical and chemical properties and purity, dosage form selection, prescriptionRead more
Mar 11,2021
Models of aging in non-human primates
The human population has begun to continue to transform into an elderly population, which requires biomedical research to better understand the basic biology of aging and age-related diseases, and to promote new and improved treatment options. The breadth of carrying out this research is impractical, so animal models are needed to decompose the complexity ofRead more
Feb 19,2021
The latest progress and development trend of autoantibody indirect immunofluorescence detection technology
Autoantibody detection is an important method for diagnosing autoimmune disease (autoimmune disease, AID). Commonly used detection methods include indirect immunofluorescence (IIF), enzyme-linked immunoassay (ELISA), western blotting, etc., with the continuous innovation of biotechnology , Auto-antibody detection has been gradually applied to autoantibody detection by technologies such as magnetic bead particle chemiluminescence, immune microarray, and flowRead more
Feb 09,2021
Brief Introduction of the Relationship Between GM-CSF Cytokines And Immune diseases
Granulocyte-macrophage colony stimulating factor (GM-CSF) cytokine is an active immune effector factor with a wide range of immune activities in the body. As an immune adjuvant, it can not only promote the maturation of APCs (such as DC and macrophages) and improve its antigen presentation ability, but also play a role in T cell-mediated inflammatoryRead more
Feb 08,2021
Peripheral Protein Signaling May Help Early Diagnosis of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that is harmful to human health. More and more studies have found that the study of protein characteristics in the peripheral blood of AD patients is helpful for the early diagnosis of AD or Monitor the progress of the disease. The protein in the peripheral protein has theRead more
Jan 28,2021
COVID-19: The Virus Keeps Mutating, is Our Vaccine Still Effective?
Recent viral mutations of COVID-19 may inhibit the effectiveness of the current two vaccines to a certain extent. Researchers have recently expressed concern about this preliminary finding, because it also largely predicts that future mutations may destroy the vaccine’s effectiveness. Effectiveness. The study tested coronaviruses from the United Kingdom, South Africa, and Brazil, and wasRead more
Jan 27,2021
Analysis on the Preparation and Development Trend of Monoclonal Antibodies
Currently, monoclonal antibody cloning drugs, protein drugs, gene and nucleic acid drugs, etc. are the focus of my country’s biopharmaceutical research and development. Among them, monoclonal antibody drugs, as a biologically targeted drug with unique advantages, have high specificity, strong targeting and the characteristic of low toxicity and side effects is remarkable in treating diseases.Read more
Jan 07,2021
Mysterious Bitter Receptor, Hope for the Treatment of Asthma
Although scientists have made progress in controlling asthma and chronic obstructive pulmonary disease (COPD), improper control of the symptoms of both respiratory diseases can lead to severe shortness of breath, hospitalization and even death. Dr. Stephen Liggert, associate dean of research at the University of South Florida, Mossani, said that only about 50% of asthmaRead more
Jan 01,2021
Medicilon’s pharmacology models for inflammatory-immune diseases
Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and
Dec 15,2020
Researchers Have Discovered a Molecule that Reduces Fat Mass in Mice-BAM15
Non-alcoholic steatohepatitis (NASH), also known as metabolic steatohepatitis, is a common chronic liver disease closely related to metabolic disorders such as obesity, insulin resistance, type II diabetes, and hyperlipidemia. NASH animal model is an important vehicle for studying non-alcoholic steatohepatitis. NASH is manifested by severe liver fat accumulation and inflammation, often accompanied by fibrosis andRead more