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Jan 10,2022
Animal Disease Model
What is Animal Disease Models? Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.
Jul 12,2021
Effect of chemokine ligand 2 on the learning and memory ability of rats
CC chemokine 2 (CCL2), which is generally expressed in white blood cells and rarely expressed in normal nerve tissues, plays an important role in the innate immunity caused by tissue damage and some diseases. Numerous studies have found that CCL2 can damage the learning and memory of rats. In order to study the effect andRead more
Apr 29,2021
Research on using insect cell expression system to express immune-related molecules
Both CD4 molecule and IL-12 are hot molecules in tumor immunotherapy research. Among them, CD4 molecule has important immunological functions, it can participate in the body’s immune response, and the cytokines of the IL-12 family of interleukins play a role in immune regulation. The immune response can be formed by directly inducing the development ofRead more
Mar 11,2021
Models of aging in non-human primates
The human population has begun to continue to transform into an elderly population, which requires biomedical research to better understand the basic biology of aging and age-related diseases, and to promote new and improved treatment options. The breadth of carrying out this research is impractical, so animal models are needed to decompose the complexity ofRead more
Feb 09,2021
Brief Introduction of the Relationship Between GM-CSF Cytokines And Immune diseases
Granulocyte-macrophage colony stimulating factor (GM-CSF) cytokine is an active immune effector factor with a wide range of immune activities in the body. As an immune adjuvant, it can not only promote the maturation of APCs (such as DC and macrophages) and improve its antigen presentation ability, but also play a role in T cell-mediated inflammatoryRead more
Jan 27,2021
Analysis on the Preparation and Development Trend of Monoclonal Antibodies
Currently, monoclonal antibody cloning drugs, protein drugs, gene and nucleic acid drugs, etc. are the focus of my country’s biopharmaceutical research and development. Among them, monoclonal antibody drugs, as a biologically targeted drug with unique advantages, have high specificity, strong targeting and the characteristic of low toxicity and side effects is remarkable in treating diseases.Read more
Jan 01,2021
Medicilon’s pharmacology models for inflammatory-immune diseases
Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and
Dec 08,2020
Miraculous and Powerful Anti-aging Drugs are Coming
Cognitive ability refers to the ability of the human brain to process, store and extract information. Although everyone wants to stay sharp forever, the impact of age on cognitive ability is a fact that cannot be ignored. Especially in the elderly, the decline in executive ability and the decline in learning and memory is veryRead more
Dec 07,2020
Research on IL-33 in central nervous system diseases
Some neurological diseases are seriously plaguing people’s lives and affecting people’s health. The lack of suitable animal models that can truly reproduce the pathology and characteristics of human diseases also severely restricts the understanding of disease mechanisms. Central nervous system disease models are of great significance for studying the pathogenesis of central nervous system diseasesRead more
Dec 04,2020
Factors Affecting the Immunogenicity of Biological Drugs
Many biopharmaceuticals are immunogenic in animals. Generally speaking, drugs that show strong immunogenicity to animals are also immunogenic to humans. Therefore, immunogenicity tests are required to evaluate the safety of drugs during the development of biological drugs. . For patients, immunogenicity easily affects the safety and effectiveness of drugs, and even causes new fatal diseasesRead more
Dec 03,2020
PET technology in CNS drug development
Central nervous system disease is a disease that seriously damages human physical and mental health. Its complexity, multi-factors, and multi-gene regulation and other characteristics have led to the unclear pathogenesis of related diseases. The development of CNS drugs is very important. Significance. The blood-brain barrier is a general term for the three barriers of “blood-brain”,Read more
Sep 28,2020
Slow-release dual agonist therapy can treat hyperglycemia and obesity
China has the largest number of diabetic patients in the world, followed by India and the United States. According to the latest statistics, my country currently has 116.4 million diabetic patients. One out of every four diabetic patients in the world comes from China, and this trend is expected to continue until 2045. Currently, itRead more
Jun 16,2020
Medicilon ion channel screening service
Medicilon has a team of more than 100 chemists, and has experience in research and development cooperation with large pharmaceutical companies and biotechnology companies well-known at home and abroad. Under the leadership of experienced medicinal chemistry leaders, Medicilon provides customers with new drug development services covering a variety of targets and diseases, including from activeRead more
Apr 07,2020
How to establish an accurate pharmacology animal evaluation model for popular diseases?
Malignant tumors, Alzheimer’s disease, diabetes, rheumatoid arthritis… These intractable diseases that threaten human health have long plagued us, bringing pain and suffering to unfortunate patients, and also bringing frontline researchers Pressure and challenge. It is the peak that many scientific research institutions intend to leap, and it is also a hot potato that the marketRead more
Feb 02,2020
Taking the Responsibility and Praying for the Peace; Medicilon helps to fight the coronavirus by providing funds and technology
During the Spring Festival, China has been facing a difficult time as the coronavirus spread all over the country.  In order to stop the coronavirus,
Dec 21,2018
Research progress of highly selective mTOR inhibitors
PI3K/AKT/mTOR PI3K/AKT/mTOR is an important signaling pathway in cells, which is related to key regulators such as metabolism, cell growth, proliferation and survival in the body, and is over-activated in cancer and neurodegenerative diseases [1]. The specific process of its signaling pathway is as follows: PIP3 binds to the signaling proteins AKT and PDK1 inRead more
Nov 27,2018
35 Genes Shape Risk to Chronic Kidney Disease
Understanding the genetic makeup of complex chronic diseases is a significant step toward developing advanced diagnostics and better treatment options. In that vein, an international team of investigators led by scientists at the University of Manchester put together an extensive genome-wide association study (GWAS) to identify the genetic factors that predispose people to chronic kidneyRead more
Nov 19,2018
Life-Extending Alzheimer’s Disease Candidates Identified from Diet Supplements
Old age is the greatest risk factor for many diseases, including Alzheimer’s disease (AD) and cancer. Geroprotectors are a recently identified class of anti-aging compounds. Scientists at the Salk Institute have identified a new subclass of anti-aging geroprotector compounds that can slow aging in mice and could represent promising drug candidates for Alzheimer’s disease (AD).Read more
Nov 09,2018
Response to Immunotherapy Predicted by Extracellular Matrix Genes
Immunotherapy has been a life-saving intervention for an array of diseases, particularly cancer. However, the treatments are not suited for every patient and can lead to serious side effects and even death. Understanding which patients would be best served by immunotherapy treatments is quickly becoming an essential factor in designing treatment strategies. As such, investigatorsRead more
Nov 02,2018
Conjoined Cells Form a Potent Immunotherapy Combo
Shackled together, stem cells and platelets may help us escape cancer, report UCLA scientists. In the scientists’ new study, the cancer is leukemia, and the defiant ones include a guide, a hematopoietic stem cell (HSC), and a drug carrier, an engineered platelet. The guide brings the duo into bone marrow, and the drug carrier deliversRead more