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Jan 04,2022
Recording the Growth of Medicilon in 2021
This year, Medicilon, with persistent belief, courageously and innovatively, pursued quality, and gave birth to the power of joint growth. Today, we take you to review the 2021 and witness the growth and progress of Medicilon!
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Jan 19,2022
Medicilon MPTP Parkinson Disease Model
Medicilon has effective models for evaluating new drugs for Parkinson, including MPTP-induced mouse subacute PD model, MPTP+ probenecid-induced mouse chronic PD model, oxytremorine-induced cholinergic symptom model, etc.
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Jan 18,2022
In Vivo Tumor Models
Medicilon boasts nearly 300 in vivo tumor models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology.
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Jan 14,2022
Commonly Used Mouse and Nude Mouse Tumor Model
In animal tumor transplantation models, Kunming mice or purebred mice are often used to inoc-ulate mouse tumors, and the inhibitory effect of the test substance on tumor growth is observed.
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Jan 11,2022
Nude Mice Animal Model
Nude mice are immunodeficient animals because they have no thymus glands, so they lack immune response. Medicilon Pharmacology Service provides you with experiments on tumor formation in nude mice and subcutaneous tumor formation in nude mice.
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Jan 10,2022
Animal Model of Skin Disease
The skin is composed of two parts, the epidermis and the dermis, which are connected to the deep tissue by the subcutaneous tissue. Today, I will give you a brief introduction to the animal model of skin disease of solar dermatitis and psoriasis.
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Jan 10,2022
Animal Disease Model
What is Animal Disease Models? Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.
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Nov 16,2021
Liver Microsome Model of Drug Metabolism Model in Vitro
For those drugs with low metabolic rate, high toxicity, or lack of sensitive detection methods, in vitro drug metabolism studies can eliminate the interference of internal factors and provide reliable theoretical data for the overall experiment. The liver microsomal model is one of the common in vitro models for studying drug metabolism in laboratories. ItRead more
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Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Nov 12,2021
Artificial Intelligence Helps Drug Development
On October 22, 2021, the research group of Academician Hualiang Jiang and Mingyue Zheng from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published an article Drug target inference by mining transcriptional data using a novel graph convolutional network framework on Protein & Cell. Researchers applied the Twin Spectrogram Convolutional Network (SSGCN) toRead more
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Oct 12,2021
Caco-2 Cell Model of ADME Model in Vitro
The new drug development stage includes 4 important stages: target determination, model establishment, lead compound discovery, and lead compound optimization. After the target is determined, a biological model such as an in vitro ADME model of a drug should be established, which is mainly used to study drug absorption, distribution, metabolism and drug toxicity, inRead more
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Oct 08,2021
Choose mouse model for Tumor Immunotherapy Research
The direction of tumor immunity is undoubtedly one of the most popular directions in the field of cancer research today, but for researchers who are new to this field, the results of using only the mouse tumor model used in the previous tumor research will not be convincing. For example, The most common human tumorRead more
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Oct 08,2021
What is a Syngeneic Tumor Mouse Model?
The syngeneic tumor mouse model is one of the earliest tumor animal models, and it has a history of at least 50 years. This type of model is to transplant tumor cells or tissues derived from mice into host mice with the same genetic background and immune capabilities. The allograft (ie, tumor) formed in theRead more
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Sep 18,2021
Preclinical Research Company
Medicilon is a company engaged in pre-clinical research services (CRO), which specializes in providing customers with customizable pre-clinical trial service programs. Professional knowledge in pharmacodynamic research and toxicology. Provide you with high-quality data and fast turnaround to support various drug development, preclinical research and clinical research. Help you select the most valuable drug candidates intoRead more
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Sep 10,2021
In Vivo and in Vitro Studies of Formulation and Consistency Evaluation of Generic Drugs
In the consistency evaluation of generic drugs, it is very important to take effective measures to accurately evaluate the in vivo and in vitro relevance of drugs. Appropriate in vivo and in vitro correlation models can accurately predict the action characteristics of the drug in vivo, thereby guiding and optimizing the formulation design, establishing moreRead more
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Jul 23,2021
Preclinical and Clinical Stages of Drug Development
The preclinical stage includes the discovery and optimization of lead compounds, the establishment of targets and models. Both can be used as the starting point for drug development: 1. Lead compounds are obtained through screening models, the lead compounds are optimized, and then the model is used for evaluation; 2. Medicinal chemistry can also beRead more
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Jul 13,2021
Caenorhabditis elegans, a model animal for studying the regulation of serotonin in the brain
With the continuous improvement of biological science and technology, the current models constructed using model organisms are playing an increasingly important role in drug screening. Patients with depression and anxiety often have lower levels of serotonin in their bodies. For these patients, some drugs that increase serotonin levels are often used clinically. Serotonin, also knownRead more
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Jul 13,2021
Scientists have discovered a new anti-cancer drug-EBV protein inhibitor
Epstein-Barr virus (EBV) is a herpes virus that is pathogenic to humans. It has been found to be associated with nasopharyngeal cancer, some gastric cancer, laryngeal cancer and Hodgkin’s lymphoma. Although the proportion of EB virus directly causing cancer is very low, because of the high proportion of human infections, the eradication of cancer causedRead more
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Jul 07,2021
Selection Principles of Laboratory Animals for Drug Preclinical Research
In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more
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Apr 26,2021
Yeast two-hybrid technology and common problems
Yeast two-hybrid, proposed by Fields in 1989, is an experimental technique for studying the interactions of proteins in living cells under the eukaryotic model yeast. This system can not only detect the interactions between known proteins, but also discover unknown proteins that interact with known proteins. It is widely used in animal and plant proteinRead more
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