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Containpharmacokinetics-researchContent

Jan 10,2022
Animal Disease Model
What is Animal Disease Models? Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.
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Jan 10,2022
Clinical Research Organization Ranking
The Clinical Research Organization (CRO) helps pharmaceutical manufacturers improve efficiency and speed throughout the clinical trial process. CRO is a service organization that supports pharmaceutical and biotechnology companies in the form of outsourcing drug research services (drugs and medical devices).
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Dec 30,2021
Preclinical Researches
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Dec 30,2021
Pharmaceutical Research
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Nov 25,2021
Reagent Stability Testing of In Vitro Diagnosis
Stability research is an important content that runs through the entire IVD product development phase and supports the post-market research of IVD products. It is the basis for setting the product validity period. It can be used to judge the rationality of product production technology, formula selection, and packaging material selection. It is also AsRead more
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Nov 25,2021
The Failure of LC-MS Bioanalytical Research Method
A successful LC-MS bioanalysis method transfer can increase the confidence of the sender and recipient laboratories. However, because the transfer of LC-MS bioanalysis methods involves preliminary preparation, communication, and acceptance, and the content of each process is numerous, the negligence of individual details during the method transfer may cause the transfer to fail, and theRead more
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Nov 19,2021
Discovery and Optimization of Lead Compounds
Discovery of Lead Compounds Hit to Lead The discovery of lead compounds is the process of turning the “hits” found in screening into “lead compounds” that can be further optimized. The lead compound may be a selected compound or a series of homologs, or it may be a compound derived from literature. However, for high-throughputRead more
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Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Nov 16,2021
Pre-clinical Research Escorts the Development of Innovative Drugs
The first challenge in drug development is the pre-clinical research of new drugs, which refers to the chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics, and toxicology that are carried out before the drug enters clinical research. And pharmaceutics research. Preclinical research on new drugs escorts the development of innovative drugs.Read more
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Nov 12,2021
Artificial Intelligence Helps Drug Development
On October 22, 2021, the research group of Academician Hualiang Jiang and Mingyue Zheng from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published an article Drug target inference by mining transcriptional data using a novel graph convolutional network framework on Protein & Cell. Researchers applied the Twin Spectrogram Convolutional Network (SSGCN) toRead more
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Nov 11,2021
Preparation Method and Related Synthesis Process of Chiral Drug
Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more
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Nov 08,2021
Top 10 Global Clinical Research Organizations in 2021
In 2020, a global outbreak of the new crown epidemic disrupted the business activities of almost all companies, and the drug R&D and production of pharmaceutical companies was no exception. As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market order is chaotic.    2021Read more
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Oct 25,2021
Baculovirus Expression Vector System and its Application
The most researched insect baculovirus is Autographa californica multiple nuclear polyhedrosisvirus (AcMNPV), its host is Spodoptera frugiperda (Sf); Bombyx mori nuclear polyhedrosis virus (Bombyx) mori nuclear polyhedrosis virus (BmNPV), whose host is the silkworm (Bombyx mori), these two baculovirus vectors are often used to express foreign proteins [2,3]. The gene expression of baculovirus is dividedRead more
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Oct 21,2021
Summary of the Development and Verification of Analytical Methods for Stability Indicators in New Drug Research
In the Non-Clinical stage of new drug development, why develop methods with stability indicators? What is the difference between the non-Clinical stage degradation test and the later stage? What precautions need to be considered? Have the difficult problems in method validation trouble you for a long time? Drug Non-clinical Research and Stability Indication Method Non-clinicalRead more
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Oct 14,2021
Talking about Pharmacokinetics PK
Pharmacokinetics (pharmacokinetics, PK) and pharmacodynamics (pharmacodynamics, PD), in fact, can be described as key research content, the two complement each other and are indispensable. PK refers to the quantitative study of the changes in the in vivo processes such as absorption (A), distribution (Distribution, D), metabolism (Metabolism, M) and excretion (Excretion, E) of drugs inRead more
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Oct 13,2021
What are APIs, Original Research Drugs and Generic Drugs?
The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more
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Oct 12,2021
Understand Whether the Structure of the Synthetic API is Correct
The preparation and research of APIs is at a critical position in the chemical drug R&D process, and the structure of the prepared compounds is consistent to ensure that subsequent quality control studies, pharmacology and toxicology studies, and clinical studies are meaningful. Through the structure of the synthesized APIs Confirmation can characterize whether the structureRead more
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Oct 11,2021
Video of Medicilon Preclinical Research Services
Related Articles: What is Preclinical Trails? Integrated Preclinical Trails Services New Drug Preclinical Trails
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Oct 11,2021
Nine Development Trends of Chemical Synthetic Drugs
As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals orRead more
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Oct 11,2021
Six Directions of Chemical Synthesis Drug Research and Development
As an important part of the development of the pharmaceutical industry, chemically synthesized drugs are the main source of drug candidates, as well as a high-input, high-output and high-efficiency work. The main directions for chemical synthesis drug research and development are as follows. Research and Develop New Chemical Entity Drugs New Chemical Entities (NCE) drugsRead more
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