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Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Oct 14,2021
Talking about Pharmacokinetics PK
Pharmacokinetics (pharmacokinetics, PK) and pharmacodynamics (pharmacodynamics, PD), in fact, can be described as key research content, the two complement each other and are indispensable. PK refers to the quantitative study of the changes in the in vivo processes such as absorption (A), distribution (Distribution, D), metabolism (Metabolism, M) and excretion (Excretion, E) of drugs inRead more
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Sep 29,2021
Integrated Preclinical Trials Services
COMPANY PROFILE Shanghai Medicilon Inc. is one of the top contract research organizations (CRO) in China. Since its establishment in 2004, Medicilon has been striving to offer fully integrated pharmaceutical services for the global scientific community. We have over 1,900 employees cross biology, chemistry and preclinical research. Over 30% of our employees have M.S. andRead more
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Sep 28,2021
Asaron Pharmacokinetics and Bioavailability Test
Asarone is based on a-asarone (2,4,5-trimethoxy-1-alkenylbenzene, also known as a-Asarone), the main active ingredient in the traditional Chinese medicine Acorus calamus. It is artificially synthesized to relieve cough and asthma. Anti-epileptic drugs. Since the blood concentration of the drug after entering the human body is very low, it is difficult to carry out pharmacokinetic studiesRead more
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Sep 18,2021
Preclinical Research Company
Medicilon is a company engaged in pre-clinical research services (CRO), which specializes in providing customers with customizable pre-clinical trial service programs. Professional knowledge in pharmacodynamic research and toxicology. Provide you with high-quality data and fast turnaround to support various drug development, preclinical research and clinical research. Help you select the most valuable drug candidates intoRead more
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Sep 16,2021
Application of Stable Isotope-Labeled Drugs in Clinical Pharmacokinetic Research
Clinical pharmacokinetics (Clinical Phamacokinetics) research has revealed the mystery of the fate of many drugs in the body, and has enriched the knowledge of human clinical rational use of drugs. It undoubtedly plays an important guiding role in avoiding the occurrence of adverse drug reactions and improving the level of drug treatment. The key toRead more
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Sep 15,2021
The Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies and Their Application in Disease Treatment
Therapeutic monoclonal antibodies are currently one of the hotspots in the development of new drugs. Compared with traditional small molecule drugs, their pharmacokinetic characteristics and formation mechanisms are very different. A full understanding of these mechanisms and characteristics can effectively guide Screening and development of monoclonal antibody drugs. Monoclonal antibody drugs provide ideal means forRead more
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Sep 15,2021
Study on the Pharmacological Effects of Dendrobium Nobile and its Pharmacokinetics in Rats
Dendrobium nobile has a long history of medicinal use. It is a common traditional Chinese medicine. The chemical components are divided into alkaloids, glycosides, phenanthrene and bibenzyls according to the structure type. Its pharmacological effects are mainly manifested in anti-tumor, hypoglycemic and anti- Nervous system protection and other aspects. The pharmacokinetic study of dendrobine inRead more
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Sep 14,2021
DMPK and Mechanism of Drug Interaction
When treating diseases, patients often need to receive more than one drug to enhance the therapeutic effect. When multiple drugs are administered at the same time, drug-drug interaction (DDI) may occur. Drug interaction based on pharmacokinetics is one of the main ways of drug interaction, including the interaction in the four links of drug absorption,Read more
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Sep 13,2021
Study on the Pharmacokinetics of Gastrodin and its Pharmacological Effects
Gastrodia is a dry tuber of the orchid plant Gastrodia elata. It is a traditional and precious Chinese medicine for calming the liver, relieving wind and relieving spasm. Gastrodin is the main active ingredient of Gastrodia. Pharmacological studies have shown that Gastrodia has sedative, anti-convulsant, anti-epileptic properties, and increases cerebral blood flow. Protect nerve cellsRead more
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Sep 13,2021
Medicilon appoints Dr. Hong Wan as Vice President of DMPK and Bioanalysis Department
Recently, Shanghai Medicilon Inc. (stock code: 688202.SH) (Medicilon) announced the appointment of Dr. Hong Wan as Vice President of DMPK and Bioanalysis Department. Dr. Hong
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Aug 20,2021
What is pharmacokinetics?
In drug development, various parameters need to be established in preclinical trials before the drug is approved for preliminary testing in human subjects. Pharmacokinetics is an area of ​​research that helps scientists understand how molecules behave in the body. Overview of Pharmacokinetics Pharmacokinetics, sometimes referred to as PK (Pharmacokinetic), is a branch of pharmacology thatRead more
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Mar 10,2021
Pharmacokinetics and biological analysis of ophthalmic drugs
Eyes are the most sensitive organs of human beings. Generally, their sophisticated functional structure prevents foreign bodies from intruding or removing foreign bodies. The importance of eyes is self-evident, but eye diseases are too numerous to mention. There are currently more than 500 eye diseases known, such as refractive errors (myopia, hyperopia, astigmatism), dry eye,Read more
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Mar 10,2021
Pharmacokinetics and Bioanalysis of Chiral Drugs
Stereoisomers are compounds in which the structural groups in the molecule are arranged differently in three dimensions without changing the atomic composition, atom-atom connection mode, and bonding sequence. Stereoisomers are divided into two categories: Enantiomers and Diastereoisomers. Enantiomers (ie, enantiomers) refer to stereoisomers that cannot overlap in space and are mirror images of each other,Read more
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Mar 10,2021
Pharmacokinetic data management and statistical calculation methods that meet regulatory requirements
In some clinical trials, the results of bioequivalence (BE) and pharmacokinetics (PK) are the main endpoints of the study. Therefore, the data management, statistical calculation process and the compliance, consistency and completeness of the results It will be the focus of review and on-site verification. Recently, the State Food and Drug Administration (CFDA) successively promulgatedRead more
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Mar 10,2021
Evaluation and thinking on racial differences in pharmacokinetics
Racial /Ethnical sensitivity is an important factor that affects the effectiveness and safety of drugs in different ethnic groups. Among them, pharmacokinetics (PK) is the most important source of drug racial sensitivity. one. According to the definition of racial factors in ICHE5 [1], factors that cause racial differences include internal factors such as genetics andRead more
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Mar 09,2021
Pharmacokinetics and pharmacodynamics
Pharmacology is the science of studying the dosage, mechanism of action and curative effect of drugs. The core of pharmacology is the study of pharmacokinetics and pharmacodynamics. What is pharmacokinetics, pharmacodynamics and pharmacokinetics/pharmacodynamics? Pharmacokinetics studies the concentration of drugs in the body at different time points. On the other hand, pharmacodynamics studies the relationship betweenRead more
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Mar 08,2021
The impact of antibody targets on ADC pharmacokinetics
Tumor treatment is ushering in the era of ADC drugs. ADC is linked by a powerful cytotoxic payload drug and tumor-targeting antibody by a chemical linker, usually the drug-antibody ratio (DAR) is 3.5-4. The design principle is to directly deliver cytotoxic drugs to the tumor part through antibodies without harming healthy cells. ADC drugs approvedRead more
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Mar 05,2021
The role of pharmacokinetics in the calculation of the initial dose of innovative drugs in the first human trial
Whether the initial dose of the first human trial is reasonable or not is directly related to the success or failure of the trial. When determining the initial dose, it is necessary to comprehensively consider the existing animal efficacy, toxicity and pharmacokinetic research data, and it is necessary to avoid excessive initial doses. It canRead more
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Mar 05,2021
Clearance Rate Pharmacokinetics
Pharmacokinetics is a branch of pharmacology, which provides a mathematical basis for evaluating the time course of drugs in the body and their effects. Pharmacokinetics can quantify the following processes: drug absorption, distribution, metabolism, and excretion. After the patient takes the drug, these pharmacokinetic processes (commonly called ADME) determine the concentration of the drug inRead more
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