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Nov 24,2021
Two Innovative Service Platforms of Medicilon were Selected as
Recently, the “2021 Yangpu Service Trade Digital Transformation Forum” under the guidance of the Shanghai Municipal Commission of Commerce and the People’s Government of Yangpu
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Nov 19,2021
Injection vs. Oral Solid Dosage
From the perspective of various stages, there are big differences between domestic generic drug injections and oral solid dosages in terms of generic drug consistency evaluation, competition pattern, and overall market size. Domestic sales of injections account for too much From the PDB sample data, injections account for more than 60% of domestic prescription drugRead more
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Nov 19,2021
The Current Situation of Domestic Oral Solid Dosage Industry
Oral solid dosage usually refer to the general term for the preparation of tablets, capsules, granules, etc., after natural medicines are crushed and extracted. This article will briefly introduce the difficulty of evaluating the consistency of generic drugs and the competitive landscape of oral solid dosage. It is Difficult to Evaluate the Consistency of OralRead more
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Nov 18,2021
Consistency Evaluation of Oral Solid Dosage
As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid dosage forms for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more
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Nov 18,2021
Storage Time of Oral Solid Dosage
FDA declaration 3.2.P.3.4 includes three contents. Acceptance criteria and test results of registered batches;Comparison table of equipment and control standards used in registered batches and commercial batches;Intermediate storage information. The contents of the first and second items may be familiar to everyone. Therefore, this article mainly introduces the third item, the key point of intermediateRead more
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Oct 13,2021
What are APIs, Original Research Drugs and Generic Drugs?
The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more
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Sep 28,2021
Improving Oral Bioavailability of Poorly Water-soluble Drugs
In the past decade, the discovery of poorly soluble drugs has prompted a continuous need to develop a new dosage form to increase the solubility of these drugs. They increase the solubility of the drug in the gastrointestinal tract by increasing the dissolution rate of the drug in the gastrointestinal tract, thereby promoting the absorptionRead more
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Sep 28,2021
Bioavailability of Different Dosage Forms of Glimepiride
Glimepiride belongs to the third generation of sulfonylureas and is widely used clinically in the treatment of type 2 diabetes. Tablets and pills are common dosage forms of glimepiride. Using in vitro dissolution tests to determine the bioavailability of glimepiride tablets and dropping pills can evaluate the quality of glimepiride in different dosage forms producedRead more
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Sep 22,2021
Direct vs Indirect Elisa
All you need to know about the ELISA experiment is here. ELISA, the full name of enzyme-linked immunosorbent assay, is a commonly used immunoassay method; Detection Principle The known antigen or antibody is adsorbed on the surface of the solid phase carrier, the antigen or antibody is labeled with enzyme, and the antigen or antibodyRead more
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Sep 06,2021
Analysis of the Characteristics of Aerosol and Preformulation Research
Aerosol is a dosage form of medicine. It is a dispersion system composed of fine liquid droplets or solid particles (dispersed inner phase) in air or mixed gas (dispersed outer phase). The dispersed ions are extremely small, and the diameter is from 1 to hundreds of nanometers. , Generally divided into high, medium and lowRead more
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Sep 02,2021
Factors Influencing the Dissolution of Solid Dosage Forms
In theory, in vivo drug testing is the most important and reliable basis for evaluating drugs. However, in the development of oral solid dosage forms, the method of measuring bioavailability is used to screen and evaluate each new prescription and process, which is time-consuming and costly. money. Although the results of in vivo and inRead more
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Sep 02,2021
Method for Checking the Water Content in the Development of Solid Dosage Forms
Medicines are the foundation for human survival and social development, and are related to people’s lives, health and safety. In the research and development of solid dosage forms, some drugs need to be treated with water, and some need to be added with a certain amount of liquid excipients. Improper operation will affect the qualityRead more
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Aug 31,2021
Selection of Excipients for Oral Solid Dosage Process Research
It is well known that medicine is a special commodity that can meet people’s needs for treatment and rescue. However, pharmaceutical preparations involve a lot of content in the process of research and development. In drug development, it may be affected by such things as low level of drug development, more repetitive drugs, and drugRead more
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Aug 04,2021
ELISA Experiment Guide: Indirect ELISA
Indirect ELISA Indirect ELISA is illustrated in the figure below and Figure 2. Phases I and II are similar to the direct system.Phase III involves adding unlabeled detection antibodies that are diluted in the buffer to prevent the proteins in the antiserum from nonspecifically attaching to the solid phase (the blocking buffer). It is thenRead more
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Jul 30,2021
Preformulation Research for New Drug Development
Generally speaking, the several necessary stages of new drug development are: 1) pre-formulation research; 2) dosage form selection, which is to determine the appropriate dosage form according to the physical and chemical properties of the drug, clinical treatment and application needs; 3) prescription research, That is, according to the physical and chemical properties of theRead more
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May 06,2021
Analysis of the influence of compound dosage on pharmacological effects
In new drug research, determining the dosage of different animals is a problem that needs to be paid attention to in pharmacological research. The pharmacological effect is proportional to the dose of the drug within a certain range, that is, the dose-effect relationship. The dose of the drug has an impact on the effect ofRead more
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Apr 02,2021
Influencing factors of wrong results of ELISA
Influencing factors of wrong results of ELISA ELISA, or enzyme-linked adsorption test, is a commonly used solid-phase enzyme immunoassay method. Engvall and Perlmann first applied this method to quantify IgG in 1971, and named it “enzyme linked immunosorbent assay (ELISA)“. ELISA The basic principle of ELISA is: ① Make the antigen (or antibody) bind toRead more
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Apr 02,2021
The operation points of ELISA technology!
High-quality reagents, good instruments and correct operation are necessary conditions to ensure the accuracy and reliability of ELISA test results. The operation of ELISA differs due to the formation of solid-phase carriers, and domestic medical tests generally use plate-type dots. This article will describe the main points of attention for each operation step of plateRead more
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Apr 02,2021
ELISA technology’s technical details
ELISA: The full name is enzyme-linked immunosorbent test. Its principle is: during the measurement, the test specimen reacts with the antigen or antibody on the surface of the solid-phase carrier, and the antigen-antibody complex formed on the solid-phase carrier is washed into the solution. Separate the other substances, add enzyme-labeled antigen or antibody, and bindRead more
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Apr 01,2021
The operation points of ELISA technology
High-quality reagents, good instruments and correct operation are necessary conditions to ensure the accuracy and reliability of ELISA test results. The operation of ELISA differs due to the formation of solid-phase carriers, and domestic medical tests generally use plate-type dots. This article will describe the main points of attention in each operation step of plateRead more
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