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Introduction of KRAS

2023-11-14
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RAS is a family of GTPase proto-oncogenes, comprising three closely related RAS isoforms: HRAS, KRAS and NRAS.

From all of the RAS isoforms, KRAS is most frequently mutated.

KRAS mutations are particularly frequent in the pancreatic, lung and colorectal cancers.

KRAS gene is a proto-oncogene that encodes a GTP/GDP-binding protein that belongs to the GTPase RAS family.

The KRAS protein acts as molecular switchs that cycle between a GDP-bound inactive state and a GTP-bound active state.

KRAS protein switches between an inactive to an active form via binding to GTP and GDP(闪), respectively.

  • KRAS-targeted Drugs R&D Service.webp
    KRAS-targeted Drugs R&D Service

    In the formulation of KRAS integrated research plan, Medicilon has in-depth communication with customers. The backbone of scientific research has combined the characteristics of each case with years of practical experience and technical accumulation, and carefully submitted high-quality experimental plans and results to customers. Medicilon provides KRAS-targeted drug discovery, CMC research (API + formulation), pharmacodynamics research, PK study, safety evaluation and other services.

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