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What is Accelerated Stability Testing?

2021-07-22
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The accelerated stability test places perishable products under stress to estimate the shelf life under normal conditions. In this test, the company encourages the product to fail in a short period of time in harsh environments, and use this to estimate what might happen under normal conditions. This eliminates the need to store the product for months or years for stability testing
The accelerated stability test places perishable products under stress to estimate the shelf life under normal conditions. In this test, the company encourages the product to fail in a short period of time in harsh environments, and use this to estimate what might happen under normal conditions. This eliminates the need to store products for months or years for stability testing and waiting for them to fail. This method is impractical. Once the company has determined a reasonable range of stability, they can mark the future operation of the product with an appropriate expiration date. Accelerated stability testing of drugs can be performed. Product storage recommendations can specify temperature, humidity and pH. In the stability test, the company needs to keep a product sample under appropriate conditions and monitor it to determine when the product fails. Technicians can also conduct a second accelerated test to estimate when the product will fail and prepare a reasonable shelf life inference so that the product can be marketed. Accelerated testing accelerates the process of heating, improper humidity, and pH imbalance in the occurrence of failures. Accelerated stability testing includes measuring pH and so on. Controlled conditions are essential to accelerate stability testing. The technician carefully monitors all environmental factors when testing the product, and repeats the test until the decomposition begins. This can be used to evaluate medicines and foods, both of which have perishability issues. As far as medicines are concerned, expired medicines may be ineffective and may make people sick, while old food may undergo chemical changes or be infested by organisms that may destroy it and cause illness. Material testing companies can evaluate the shelf life of the products. You can also test it yourself. Regulatory agencies usually have guidelines for accelerated stability testing to ensure its standardization and safety. Inspectors can request copies of test records related to sales and labeling product applications. They may review the documents to confirm whether the test is performed correctly, and if there is a problem, they can request a retest. One problem with this type of testing is that during accelerated stability testing, important physical and chemical changes that would not occur under normal conditions may occur. For example, if the egg is at a high temperature, the protein is denatured and the egg enters a cooked state. No matter how long the eggs are kept in the refrigerator under the recommended storage conditions, they will not be cooked. Therefore, the usefulness of the test is a controversial topic because it is difficult to accurately map the results of the accelerated stability test to normal storage conditions.

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