ABOUT
- The skin is the first line of physical defense in the human body. It is the largest organ of the human body which participates in various physiological functions . It consists of three easily distinguishable layers: the stratum corneum, the living epidermis and the dermis. [1-3]Skin diseases are complex and diverse, causing various degrees of disease which could burden on the entire life cycle of humans. Skin topical medicine is a kind of preparations that act on local or systemic treatment. The semi-solid topical preparations, which is a type of common preparation applied in skin medicine, are multiphase,. thermodynamically unstable and complex in composition,. It is classified as a complex preparation and has applications in the fields of innovative drugs, improved new drugs and generic drugs. [1-3]
List of Topical Skin Preparations- GelOintmentSolution type ointmentSuspended ointment CreamOil-in-water creamWater-in-oil cream
Medicilon’s Services- Medicilon can undertake the development process of various topical skin preparations, including ointments, creams, gels and other semi-solid preparations, as well as lotions, liniments and other solutions. Medicilon fully complies with the requirements of China and global laws and regulations and guiding principles, as well as many years of development and research experience. Medicilon has completed the development and application of a number of external preparation research projects for pharmaceutical companies and scientific research institutes.Among them, Medicilon is well versed in the specificity of semi-solid preparations for skin topical in terms of technology development and review and approval, and comprehensively considers the product’s prescription technology, quality control, packaging materials, commercial production and clinical application. Based on the analysis of the quality research profile, the key quality attributes (CQAs) of the products are used as the inspection indicators to conduct a sufficient screening study on the types and dosages of excipients.
- Study on the Quality of Topical Preparations:Formulation pHWater Activity Ratio of Undissolved Drug/Dissolved DrugRheological PropertiesCharacterization of Shear Stress and Shear RateYield Stress ValueLinear Viscoelastic ResponseViscosity CurveLinear Viscoelastic RangeIn Vitro Release Test/In Vitro Permeation Test (IVRT/IVPT)Particle Size and Droplet Size Distribution Measurement Establishment of Microbiological Inspection MethodsEstablishment of Test Method for Burkholderia CepaciaEstablishment of Antibacterial Efficacy Method)
Schematic Diagram of Rheological Research in Semi-Solid Formulations
Schematic Diagram of Drug Absorption in Topical Formulations
Schematic Diagram of Rheological Research in Semi-Solid Formulations
Our platform is equipped with state-of-the-art and complete instruments to complete the various test items mentioned above:
- Analysis EquipmentBrookfield Viscometer Image Analysis System for Measuring Droplet/Particle Size Distribution HAAKE MARS RheometerFranz Diffusion Cell (with Automatic Sampling System)LC/MS System
- Preparation EquipmentShearing InstrumentHomogenizer Filling Equipment
- Reference:
[1] Hyunjae Lee, et al. Device-assisted transdermal drug delivery. Adv DrugDeliv Rev. 2018 Mar 1;127:35-45.
[2] Mark R Prausnitz, et al. Transdermal drug delivery. Nat Biotechnol.2008 Nov;26(11):1261-8.
[3] Muhammad Yasir Siddique, et al. Microemulsified Gel Formulations for Topical Delivery of Clotrimazole: Structural and In Vitro Evaluation. Langmuir. 2021 Nov 23;37(46):13767-13777.
