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Preclinical Research

Tumor Models

Medicilon boasts nearly 300 tumor evaluation models. At the same time, we are empowering innovative therapies to comprehensively evaluate and study immuno-oncology. We have completed model establishment and efficacy evaluation of immuno-therapies such as CAR-T, TCR-T, CAR-NK, oncolytic virus, antibody (monoclonal antibody, double antibody, polyclonal antibody, etc.), siRNA, AAV.

PDX Models
Patient-Derived Tumor Xenograft Model (PDX): This model is established by directly transplanting the patient's tumor tissue into immunodeficient mice. The characteristics of most primary tumors in histopathology, molecular biology and gene level, ensuring relatively reliable predictions of clinical efficacy. Therefore, the platform is widely used in the development of new drugs, especially in the selection of patients in clinical trials of target drugs and the study of predictive biomarkers.
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Transgenic Models
We can provide various effective transgenic models to test the effectiveness of drugs according to our clients’ requirements. Typical orthotopic diseases include hPD-1 and hCTLA4, with mice, rats and hamsters as test subjects.
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Humanized Mouse Models
Humanized mice can easily simulate the biological characteristics of human beings. They are very important for the establishment of preclinical pharmacodynamic evaluation models, and can provide suitable pharmacodynamic models for testing biotechnology drugs such as antibodies or antibody drug conjugates (ADCs).
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Syngeneic Mouse Models
The syngeneic mouse model tests the ability of model animals to fight cancer with their perfect immune system, as well as the therapeutic effects of immunotherapy. We can provide various syngeneic models to test the effectiveness of drugs according to our clients’ requirements. Typical orthotopic diseases include breast cancer, lung cancer, colon cancer, kidney cancer, diffuse large B-cell lymphoma (DLBCL), etc., with mice, rats and hamsters as test subjects.
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Orthotopic Cancer Models
The orthotopic cancer model considers the interaction between tumor cells and their surrounding interstitial organ microenvironment and monitors tumor growth in drug efficacy evaluation. We can break down the barriers of experiment and technology with mature orthotopic transplantation models, including brain orthotopic transplantation, liver orthotopic transplantation, lung orthotopic transplantation, tibial bone marrow cavity orthotopic transplantation, and intravesical orthotopic transplantation.
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Xenograft Models
We can provide various xenograft models to test the effectiveness of drugs according to our clients’ requirements. Typical orthotopic diseases include head and neck cancer, lung cancer, breast cancer, gastric cancer and pancreatic cancer, with mice, rats and hamsters as test subjects. We are committed to providing clients with mature orthotopic models for evaluating the in vivo efficacy of ADC, completing the modeling and feeding of model animals in an AAALAC-accredited environment, and relevant pharmacodynamic evaluation experiments standards of a GLP level.
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