Tumor Models

Cell line-derived xenograft (CDX) models are among the most commonly used research models for efficacy evaluation of anti-cancer therapies. CDX models are created by implanting cancer cell lines into immunodeficient mice and have contributedsignificantly to the development of cancer drug therapies. The establishment of CDX models involves inoculation of tumor cells (including various types of cancer cells) into immunodeficient mice. After high-throughput drug screening in vitro, the CDX model is then used for in vivo drug infusion and efficacy evaluations. Due to long-term cell passage in vitro, cells have the characteristics of high homology and reproducibility. However, cell lines often lose their original biological characteristics through many passages. CDXs can be complementary to tumor biopsies and PDXs. CDXs offer an opportunity to generate models for those patients that cannot undergo surgery or an alternative invasive procedure.

Genetically engineered mouse (GEM) models are widely used and have proved to be a powerful tool to improve drug discovery processes. Using transgenic technology, extra DNA that encodes the gene of interest can be integrated into the mouse genome; using knockout or knock-in technology, specific regions of the mouse genome can be selectively deleted or modified.

Humanized mice can simulate key biological characteristics of human beings, and they are very useful for establishing preclinical pharmacodynamic evaluation models. They can provide suitable pharmacodynamic models for testing protein-derived drugs such as antibodies or antibody-drug conjugates (ADCs).

Syngeneic mouse models test the ability of animals to fight cancer with an intact immune system and is used to test the therapeutic effects of immunotherapy. We can provide various syngeneic models to test the effectiveness of drugs according to our clients' requirements. Typical orthotopic disease models include breast cancer, lung cancer, colon cancer, kidney cancer and diffuse large B-cell lymphoma (DLBCL), utilising mice, rats and hamsters as test subjects.

The orthotopic cancer model assesses the interaction between tumor cells and drugs in their natural organ/microenvironment and monitors tumor growth in situ. We have a variety of mature orthotopic transplantation models available, including brain, liver, lung, tibial bone marrow cavity, and intravesical orthotopic transplantation models.

We can provide various xenograft models to test the effectiveness of drugs according to our clients' requirements. Typical diseases include head and neck cancer, lung cancer, breast cancer, gastric cancer and pancreatic cancer, with mice, rats and hamsters as test subjects. We are committed to providing clients with mature orthotopic models for evaluating the in vivo efficacy of ADC, completing the modeling and feeding of model animals in an AAALAC-accredited environment, and relevant pharmacodynamic evaluation experiments standards of a GLP level.